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PENK

GENERAL INFORMATION

Gene name

 PENK

Gene description

 Proenkephalin

Protein class

 Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (lung cancer)
HPA (cell line):Cell line enhanced (ASC TERT1, BJ, THP-1)
HPA (normal tissue):Group enriched (adrenal gland, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in adrenal medulla.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA013138 , CAB016390
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (lung cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA013138
CAB016390

GENE INFORMATION

Gene name

 PENK

Synonyms

Description

 Proenkephalin (HGNC Symbol)

Entrez gene summary

 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 56436674 - 56446734

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181195 (version 83.38)

Entrez gene

 5179

UniProt

 P01210 (UniProt - Evidence at protein level)

neXtProt

 NX_P01210

Antibodypedia

 PENK antibodies

PROTEIN BROWSER
PENK-001
PENK-002
PENK-003
PENK-005
PENK-007
PENK-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PENK-001
ENSP00000400894
ENST00000451791
P01210 [Direct mapping]
Proenkephalin-A Synenkephalin Met-enkephalin PENK(114-133) PENK(143-183) Met-enkephalin-Arg-Gly-Leu Leu-enkephalin PENK(237-258) Met-enkephalin-Arg-Phe
A0A024R7V4 [Target identity:100%; Query identity:100%]
Proenkephalin, isoform CRA_a
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001515 [opioid peptide activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007218 [neuropeptide signaling pathway]
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 267 aa
30.8 kDa 		Yes 0
PENK-002
ENSP00000324248
ENST00000314922
P01210 [Direct mapping]
Proenkephalin-A Synenkephalin Met-enkephalin PENK(114-133) PENK(143-183) Met-enkephalin-Arg-Gly-Leu Leu-enkephalin PENK(237-258) Met-enkephalin-Arg-Phe
A0A024R7V4 [Target identity:100%; Query identity:100%]
Proenkephalin, isoform CRA_a
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001515 [opioid peptide activity]
GO:0001649 [osteoblast differentiation]
GO:0001662 [behavioral fear response]
GO:0001666 [response to hypoxia]
GO:0001964 [startle response]
GO:0002118 [aggressive behavior]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007218 [neuropeptide signaling pathway]
GO:0007568 [aging]
GO:0007626 [locomotory behavior]
GO:0009314 [response to radiation]
GO:0009636 [response to toxic substance]
GO:0014009 [glial cell proliferation]
GO:0019233 [sensory perception of pain]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032280 [symmetric synapse]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0034599 [cellular response to oxidative stress]
GO:0035094 [response to nicotine]
GO:0035641 [locomotory exploration behavior]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043278 [response to morphine]
GO:0043679 [axon terminus]
GO:0045471 [response to ethanol]
GO:0051592 [response to calcium ion]
GO:0051867 [general adaptation syndrome, behavioral process]
GO:0070852 [cell body fiber]
GO:0071305 [cellular response to vitamin D]
GO:0071320 [cellular response to cAMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071871 [response to epinephrine]
GO:0098586 [cellular response to virus]
GO:2000987 [positive regulation of behavioral fear response]
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 267 aa
30.8 kDa 		Yes 0
PENK-003
ENSP00000430592
ENST00000518770
E5RJ72 [Direct mapping]
Proenkephalin-A
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007218 [neuropeptide signaling pathway]
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 92 aa
10.3 kDa 		Yes 0
PENK-005
ENSP00000429326
ENST00000523051
E5RIP6 [Direct mapping]
Proenkephalin-A
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007218 [neuropeptide signaling pathway]
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 79 aa
8.8 kDa 		Yes 0
PENK-007
ENSP00000430268
ENST00000517415
H0YBT5 [Direct mapping]
Proenkephalin-A
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007218 [neuropeptide signaling pathway]
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 88 aa
10 kDa 		Yes 0
PENK-010
ENSP00000428012
ENST00000518974
E5RFR1 [Direct mapping]
Proenkephalin-A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001515 [opioid peptide activity]
GO:0005576 [extracellular region]
GO:0007218 [neuropeptide signaling pathway]
Show all
 105 aa
11.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.