Expression of TNFSF12-TNFSF13 in cancer - Summary - The Human Protein Atlas

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TNFSF12-TNFSF13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TNFSF12-TNFSF13
Gene description	TNFSF12-TNFSF13 readthrough
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (BJ hTERT+, U-138 MG, U-251 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA004863 , HPA052967
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004863	HPA052967

GENE INFORMATION
Gene name	TNFSF12-TNFSF13 (HGNC Symbol)
Synonyms	TWE-PRIL
Description	TNFSF12-TNFSF13 readthrough (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7549099 - 7561601
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000248871 (version 83.38)
Entrez gene	407977
UniProt
neXtProt
Antibodypedia	TNFSF12-TNFSF13 antibodies

PROTEIN BROWSER

TNFSF12-TNFSF13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFSF12-TNFSF13-001 ENSP00000293826 ENST00000293826	A0A0A6YY99 [Direct mapping] Protein TNFSF12-TNFSF13 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0016020 [membrane] Show all	330 aa 36.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.