Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific AIPL1 LCA4 ENSG00000129221 Aryl hydrocarbon receptor interacting protein-like 1 17 6393693-6435199 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA026578 Supported Tissue enriched Not detected testis: 0.9 ARMS2 ARMD8, LOC387715 ENSG00000254636 Age-related maculopathy susceptibility 2 10 122454653-122457352 Disease related genes, Predicted intracellular proteins Evidence at transcript level HPA067225 Approved Not detected Tissue enhanced placenta: 2.1;testis: 2.8 ovary: 1.2 BEST1 BEST, BMD, RP50, VMD2 ENSG00000167995 Bestrophin 1 11 61949821-61965515 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA057464 Supported Group enriched Mixed cerebral cortex: 17.0 BFSP1 CP115, CP94, filensin, LIFL-H ENSG00000125864 Beaded filament structural protein 1, filensin 20 17493905-17569220 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA040748, HPA042038 Supported Supported Plasma membrane
Cytosol Endometrial cancer:1.39e-4 (favourable) Mixed Mixed testis: 6.5 BFSP2 CP47, CP49, LIFL-L, phakinin ENSG00000170819 Beaded filament structural protein 2, phakinin 3 133399995-133475222 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA038464, HPA062959 Supported Uncertain Plasma membrane
Cytosol Tissue enriched Not detected epididymis,lymph node: 0.4 BTBD6 BDPL ENSG00000184887 BTB (POZ) domain containing 6 14 105248490-105251093 Predicted intracellular proteins Evidence at protein level HPA031355 Approved Approved Nucleoplasm Renal cancer:6.51e-5 (favourable), Breast cancer:1.11e-4 (favourable), Pancreatic cancer:2.25e-4 (favourable) Expressed in all Expressed in all testis: 73.3 CDHR1 CORD15, KIAA1775, PCDH21, RP65 ENSG00000148600 Cadherin-related family member 1 10 84194635-84219621 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA036819 Supported Tissue enhanced Group enriched 5 rectum: 58.7;skin: 252.8 colon: 29.7 CNGB3 ACHM1, ACHM3, RMCH ENSG00000170289 Cyclic nucleotide gated channel beta 3 8 86553977-86743675 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA057244 Approved Not detected Tissue enhanced testis: 4.0 bone marrow: 2.7 CRB1 LCA8, RP12 ENSG00000134376 Crumbs family member 1, photoreceptor morphogenesis associated 1 197268204-197478455 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA061250, HPA063127 Approved Uncertain Vesicles Tissue enriched Group enriched 10 cerebral cortex: 12.1;testis: 4.9 ovary: 0.8 CRX CORD2, CRD, LCA7, OTX3 ENSG00000105392 Cone-rod homeobox 19 47819779-47843330 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA036762, HPA036763 Supported Not detected Not detected epididymis,testis: 0.3 CRYBA4 ENSG00000196431 Crystallin, beta A4 22 26621964-26630672 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA071178 Supported Tissue enhanced Tissue enhanced epididymis: 1.7 testis: 0.7 CRYBB2 CCA2, CRYB2, CRYB2A ENSG00000244752 Crystallin, beta B2 22 25219522-25231869 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA043749 Supported Approved Nucleoplasm Mixed Tissue enhanced testis: 1.5 breast,epididymis,lung,thyroid gland: 0.4 EFEMP1 DHRD, FBLN3, FBNL, MTLV, S1-5 ENSG00000115380 EGF containing fibulin-like extracellular matrix protein 1 2 55865967-55924139 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB016368, HPA049806, HPA070841, HPA071588 Supported Uncertain Mitochondria Renal cancer:3.89e-8 (unfavourable), Urothelial cancer:6.68e-5 (unfavourable), Endometrial cancer:4.72e-4 (unfavourable) Expressed in all Mixed placenta: 485.9 GJA3 CX46, CZP3 ENSG00000121743 Gap junction protein, alpha 3, 46kDa 13 20138255-20161049 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA014821 Supported Tissue enhanced Tissue enhanced heart muscle: 4.7;parathyroid gland: 5.8;placenta: 3.5 testis: 2.5 GNAT1 CSNBAD3 ENSG00000114349 Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3 50191612-50196516 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA045393 Supported Not detected Tissue enhanced testis: 1.4 cerebral cortex: 0.3 GNGT1 GNG1 ENSG00000127928 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 7 93591573-93911265 Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA042721 Supported Mixed Tissue enriched 6 placenta: 3.9 urinary bladder: 0.6 GNGT2 GNG9 ENSG00000167083 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 17 49202791-49210574 Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA043381 Supported Renal cancer:3.11e-4 (unfavourable) Mixed Mixed spleen: 26.7 GRK1 GPRK1, RHOK, RK ENSG00000185974 G protein-coupled receptor kinase 1 13 113667155-113737735 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA035200, HPA059376 Supported Tissue enhanced Not detected thyroid gland: 0.8 GRM6 CSNB1B, GPRC1F, mGlu6, MGLUR6 ENSG00000113262 Glutamate receptor, metabotropic 6 5 178978327-178996206 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA014511 Supported Not detected Not detected testis: 0.8 GUCA1A C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1 ENSG00000048545 Guanylate cyclase activator 1A (retina) 6 42155406-42180056 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA005561 Supported Approved Uncertain Plasma membrane Tissue enriched Tissue enriched 19 testis: 30.0 cerebral cortex: 1.6 IMPG1 GP147, IPM150, SPACR ENSG00000112706 Interphotoreceptor matrix proteoglycan 1 6 75921115-76072678 Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA027142, HPA030332, HPA030333 Supported Not detected Mixed epididymis: 2.6 IMPG2 IPM200, RP56 ENSG00000081148 Interphotoreceptor matrix proteoglycan 2 3 101222546-101320560 Disease related genes, Predicted membrane proteins Evidence at protein level HPA008779, HPA015907 Supported Tissue enriched Tissue enriched 44 fallopian tube: 15.5 appendix,lymph node,spleen: 0.3 KRT12 K12 ENSG00000187242 Keratin 12, type I 17 40861303-40867210 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA055217, HPA055835 Supported Mixed Not detected small intestine: 0.7 LGSN GLULD1, LGS ENSG00000146166 Lengsin, lens protein with glutamine synthetase domain 6 63275951-63319977 Predicted intracellular proteins Evidence at protein level HPA030957, HPA039983 Supported Approved Nucleoplasm
Vesicles Tissue enhanced Tissue enhanced kidney: 2.8;liver: 2.4;placenta: 1.8 testis: 0.7 MIP AQP0, LIM1, MP26 ENSG00000135517 Major intrinsic protein of lens fiber 12 56449502-56469166 Disease related genes, Predicted membrane proteins Evidence at protein level HPA014940 Supported Not detected Tissue enhanced testis: 1.2 cerebral cortex,liver: 0.2 MYO3A DFNB30 ENSG00000095777 Myosin IIIA 10 25934267-26212527 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA048951, HPA051893 Approved Supported Plasma membrane
Actin filaments
Cytoplasmic bodies Mixed Tissue enriched 9 testis: 6.8 skin: 0.8 NPVF C7orf9, RFRP ENSG00000105954 Neuropeptide VF precursor 7 25224570-25228486 Predicted secreted proteins Evidence at protein level HPA041733 Approved Not detected Not detected tonsil: 0.3 NRL D14S46E, NRL-MAF, RP27 ENSG00000129535 Neural retina leucine zipper 14 24080107-24115014 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB026066, HPA064599 Supported Supported Nucleoplasm
Cytosol Mixed Mixed parathyroid gland: 4.1 OPN1SW BCP, BOP, CBT ENSG00000128617 Opsin 1 (cone pigments), short-wave-sensitive 7 128772491-128775790 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA013562, HPA014083 Supported Renal cancer:2.26e-8 (unfavourable), Stomach cancer:5.98e-8 (unfavourable), Liver cancer:8.50e-5 (unfavourable), Urothelial cancer:9.33e-4 (unfavourable) Expressed in all Mixed smooth muscle: 14.7 OPN4 melanopsin, MOP ENSG00000122375 Opsin 4 10 86654557-86666848 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA039147 Approved Not detected Tissue enhanced cerebral cortex: 2.2;parathyroid gland: 1.4 skeletal muscle: 0.9 OPN5 dJ402H5.1, neuropsin, TMEM13 ENSG00000124818 Opsin 5 6 47781982-47832780 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA026084 Supported Not detected Tissue enriched 42 testis: 4.3 heart muscle: 0.1 OPTC ENSG00000188770 Opticin 1 203494143-203508864 Predicted secreted proteins Evidence at protein level HPA034951, HPA034952 Supported Tissue enriched Not detected testis: 0.6 PDC MEKA ENSG00000116703 Phosducin 1 186443566-186461122 Predicted intracellular proteins Evidence at protein level HPA062235 Supported Not detected Not detected testis: 0.4 PDE6B CSNB3, CSNBAD2, PDEB, rd1, RP40 ENSG00000133256 Phosphodiesterase 6B, cGMP-specific, rod, beta 4 625584-670782 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA054148, HPA059929 Supported Approved Cytosol Lung cancer:5.34e-4 (favourable) Mixed Mixed cerebral cortex: 22.4 POU4F1 BRN3A, RDC-1 ENSG00000152192 POU class 4 homeobox 1 13 78598362-78603560 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA068024 Supported Mixed Tissue enhanced testis: 2.4 tonsil: 0.7 PRKCZ PKC2 ENSG00000067606 Protein kinase C, zeta 1 2050470-2185395 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA021851 Supported Approved Plasma membrane
Cytosol Renal cancer:1.64e-9 (favourable) Expressed in all Tissue enhanced cerebral cortex: 100.0 placenta: 59.9 PRPH2 CACD2, rd2, RDS, RP7, TSPAN22 ENSG00000112619 Peripherin 2 (retinal degeneration, slow) 6 42696600-42722574 Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA029458 Supported Mixed Mixed parathyroid gland: 8.5 RB1 OSRC, PPP1R130, RB ENSG00000139687 Retinoblastoma 1 13 48303751-48481986 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000095, CAB016687, HPA050082 Supported Validated Nucleoplasm Ovarian cancer:6.92e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 36.0 RBP3 D10S64, D10S65, D10S66, RP66 ENSG00000265203 Retinol binding protein 3, interstitial 10 47348371-47357875 Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins Evidence at protein level HPA041301, HPA044239 Supported Not detected Not detected duodenum: 0.4 RCVRN RCV1 ENSG00000109047 Recoverin 17 9896320-9905621 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA015783, CAB022363 Supported Not detected Not detected cerebral cortex: 0.3 RGS9 MGC111763, MGC26458, PERRS, RGS9L ENSG00000108370 Regulator of G-protein signaling 9 17 65137431-65227703 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA013550, HPA014137 Supported Supported Uncertain Nucleoplasm Pancreatic cancer:1.35e-4 (favourable) Mixed Mixed fallopian tube: 5.8 RHO CSNBAD1, OPN2, RP4 ENSG00000163914 Rhodopsin 3 129528640-129535169 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA013440, CAB022486 Supported Not detected Not detected cerebral cortex: 0.3 ROM1 ROM, TSPAN23 ENSG00000149489 Retinal outer segment membrane protein 1 11 62611722-62615120 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA028910 Supported Approved Plasma membrane
Cytosol Renal cancer:2.85e-6 (unfavourable), Lung cancer:2.20e-4 (favourable) Tissue enriched Tissue enhanced cerebral cortex: 25.5 ovary: 13.2 RP1 DCDC4A ENSG00000104237 Retinitis pigmentosa 1 (autosomal dominant) 8 54616067-54630834 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA042257 Supported Not detected Tissue enhanced fallopian tube: 2.1 lung: 0.6 RP1L1 DCDC4B ENSG00000183638 Retinitis pigmentosa 1-like 1 8 10606349-10712187 Predicted intracellular proteins Evidence at protein level HPA024686, HPA024744 Supported Not detected Not detected skin: 0.2 RPGRIP1 CORD13, LCA6, RGI1, RPGRIP ENSG00000092200 Retinitis pigmentosa GTPase regulator interacting protein 1 14 21287939-21351301 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA042955, HPA060190 Supported Tissue enhanced Tissue enriched 47 testis: 105.6 spleen: 2.2 RS1 RS, XLRS1 ENSG00000102104 Retinoschisin 1 X 18639910-18672109 Disease related genes, Predicted secreted proteins Evidence at protein level HPA059546 Supported Not detected Group enriched 8 cerebral cortex: 1.1;lung: 1.7 lymph node,spleen,thyroid gland: 0.1 SAG ARRESTIN, RP47 ENSG00000130561 S-antigen; retina and pineal gland (arrestin) 2 233307816-233347055 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA004946 Supported Not detected Tissue enhanced testis: 1.8 epididymis: 0.9 SIX6 OPTX2, Six9 ENSG00000184302 SIX homeobox 6 14 60508951-60512850 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001403 Supported Approved Nucleoplasm Tissue enriched Not detected testis: 0.1 SLC24A1 CSNB1D, HsT17412, KIAA0702, NCKX, NCKX1, RODX ENSG00000074621 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 15 65611366-65660995 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA039370 Supported Approved Microtubules Renal cancer:2.33e-6 (favourable) Expressed in all Mixed fallopian tube: 8.7 SLC32A1 bA122O1.1, VGAT, VIAAT ENSG00000101438 Solute carrier family 32 (GABA vesicular transporter), member 1 20 38724462-38729372 Predicted membrane proteins, Transporters Evidence at protein level CAB037156, HPA058859, HPA059985 Supported Tissue enhanced Tissue enriched 34 cerebral cortex: 15.9 testis: 0.4 TRPM1 CSNB1C, LTRPC1, MLSN1 ENSG00000134160 Transient receptor potential cation channel, subfamily M, member 1 15 31001061-31161273 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA014779, HPA014785 Approved Uncertain Nucleoplasm
Cytosol Tissue enriched Group enriched 27 skin: 4.8;testis: 2.5 kidney: 0.1 UNC119 HRG4, POC7, POC7A ENSG00000109103 Unc-119 lipid binding chaperone 17 28546707-28552668 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA041912 Supported Pancreatic cancer:8.09e-5 (favourable), Melanoma:2.38e-4 (unfavourable), Thyroid cancer:9.82e-4 (unfavourable) Expressed in all Expressed in all testis: 45.4