Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific SAMD13 ENSG00000203943 Sterile alpha motif domain containing 13 1 84298366-84389957 Predicted intracellular proteins Evidence at protein level HPA058929 Supported Approved Mitochondria Glioma:2.06e-8 (favourable) Mixed Tissue enhanced rectum: 26.5;testis: 28.8 colon: 21.2 PODNL1 FLJ23447, SLRR5B ENSG00000132000 Podocan-like 1 19 13931187-13953392 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA042807 Approved Glioma:2.06e-8 (unfavourable), Urothelial cancer:4.49e-4 (unfavourable) Mixed Tissue enhanced placenta: 12.3 skin: 8.5 MIER1 hMI-ER1, KIAA1610, MI-ER1 ENSG00000198160 Mesoderm induction early response 1, transcriptional regulator 1 66924895-66988619 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA019589, HPA050306 Supported Validated Nucleoplasm Glioma:6.18e-8 (favourable), Colorectal cancer:4.96e-4 (favourable) Expressed in all Expressed in all bone marrow: 63.2 SLC6A6 TAUT ENSG00000131389 Solute carrier family 6 (neurotransmitter transporter), member 6 3 14402576-14489349 Predicted membrane proteins, Transporters Evidence at protein level HPA015028, HPA016488 Supported Approved Cell Junctions
Cytosol Glioma:1.09e-7 (unfavourable), Endometrial cancer:5.22e-5 (favourable), Liver cancer:8.78e-4 (unfavourable) Expressed in all Mixed ovary: 50.7 PTPRN IA-2 ENSG00000054356 Protein tyrosine phosphatase, receptor type, N 2 219289623-219309648 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA007152, HPA007179 Supported Approved Endoplasmic reticulum Glioma:2.45e-7 (unfavourable) Group enriched Tissue enriched 5 cerebral cortex: 183.6 adrenal gland: 35.2 MT1H MT1 ENSG00000205358 Metallothionein 1H 16 56669814-56671129 Predicted intracellular proteins Evidence at protein level Glioma:4.29e-7 (unfavourable), Renal cancer:5.44e-5 (unfavourable) Tissue enhanced Tissue enhanced kidney: 498.5;small intestine: 342.1;thyroid gland: 541.5 liver: 134.0 RPL39L RPL39L1 ENSG00000163923 Ribosomal protein L39-like 3 187120948-187180908 Predicted intracellular proteins, Ribosomal proteins Evidence at protein level HPA047105 Approved Glioma:9.50e-7 (unfavourable), Ovarian cancer:1.94e-4 (favourable), Endometrial cancer:6.05e-4 (unfavourable) Expressed in all Tissue enriched 14 testis: 222.5 breast: 16.1 EN2 ENSG00000164778 Engrailed homeobox 2 7 155458129-155464831 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB025088, HPA045646, HPA069809 Uncertain Supported Nucleus
Nucleoli fibrillar center Glioma:2.82e-6 (unfavourable) Tissue enhanced Tissue enhanced parathyroid gland: 1.9;testis: 1.1 endometrium: 0.6 FAM174A TMEM157, UNQ1912 ENSG00000174132 Family with sequence similarity 174, member A 5 100535305-100586741 Predicted membrane proteins Evidence at protein level HPA019539 Approved Approved Golgi apparatus
Cytosol Glioma:3.85e-6 (unfavourable), Renal cancer:5.48e-4 (favourable) Expressed in all Expressed in all fallopian tube: 51.2 STARD7 GTT1 ENSG00000084090 StAR-related lipid transfer (START) domain containing 7 2 96184859-96208825 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB033965, HPA064958, HPA064978 Supported Approved Mitochondria Renal cancer:4.38e-6 (favourable), Glioma:5.94e-6 (favourable), Endometrial cancer:8.56e-5 (unfavourable), Liver cancer:2.22e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 106.6 ARMC10 MGC3195, SVH ENSG00000170632 Armadillo repeat containing 10 7 103074881-103099764 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA011036, HPA011057 Supported Supported Mitochondria Pancreatic cancer:2.49e-6 (unfavourable), Glioma:6.98e-6 (unfavourable), Liver cancer:3.58e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 25.5 ZBTB6 ZID, ZNF482 ENSG00000186130 Zinc finger and BTB domain containing 6 9 122908056-122913330 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA054111, HPA076894 Approved Approved Nucleoplasm
Mitochondria Glioma:9.75e-6 (favourable), Renal cancer:5.08e-4 (favourable) Expressed in all Mixed thyroid gland: 12.5 RCOR3 FLJ10876 ENSG00000117625 REST corepressor 3 1 211258377-211316385 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA007413 Supported Approved Nucleus
Nucleoli Glioma:1.92e-5 (favourable), Lung cancer:5.75e-5 (favourable) Expressed in all Expressed in all testis: 67.1 SLC39A10 DKFZp564L2123, FLJ90515, KIAA1265 ENSG00000196950 Solute carrier family 39 (zinc transporter), member 10 2 195575977-195737702 Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA036512, HPA036513, HPA066087 Approved Approved Nucleoplasm
Plasma membrane
Cytosol Glioma:2.05e-5 (favourable), Liver cancer:4.39e-5 (unfavourable), Pancreatic cancer:3.23e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 78.0;thyroid gland: 79.0 prostate: 27.6 LRRC61 FLJ31392, HSPC295, MGC3036 ENSG00000127399 Leucine rich repeat containing 61 7 150322639-150338150 Predicted intracellular proteins Evidence at transcript level HPA019355 Approved Approved Nucleoplasm Glioma:2.15e-5 (unfavourable), Stomach cancer:2.85e-4 (favourable) Expressed in all Mixed fallopian tube: 22.4 RABGEF1 rabex-5, RABEX5 ENSG00000154710 RAB guanine nucleotide exchange factor (GEF) 1 7 66682164-66811464 Predicted intracellular proteins Evidence at protein level HPA001407 Supported Nucleoli
Cytosol Glioma:2.90e-5 (unfavourable), Renal cancer:1.27e-4 (favourable) Expressed in all Expressed in all bone marrow: 54.0 ISG20 CD25, HEM45 ENSG00000172183 Interferon stimulated exonuclease gene 20kDa 15 88636153-88656483 Enzymes, Predicted intracellular proteins Evidence at protein level HPA058356 Supported Nucleus Renal cancer:4.86e-8 (unfavourable), Ovarian cancer:1.85e-5 (favourable), Glioma:3.12e-5 (unfavourable) Expressed in all Tissue enhanced lymph node: 224.9 spleen: 138.9 DBNL HIP-55, SH3P7 ENSG00000136279 Drebrin-like 7 44044640-44069456 Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA020265, HPA027735 Supported Supported Nucleoplasm
Cytosol Glioma:3.20e-5 (unfavourable) Expressed in all Expressed in all esophagus: 142.5 ADAM15 MDC15 ENSG00000143537 ADAM metallopeptidase domain 15 1 155050566-155062775 Enzymes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA011633, HPA072878 Uncertain Uncertain Vesicles Renal cancer:5.64e-9 (unfavourable), Glioma:3.49e-5 (unfavourable), Liver cancer:3.49e-4 (unfavourable) Expressed in all Expressed in all skin: 72.8 RPP25 FLJ20374 ENSG00000178718 Ribonuclease P/MRP 25kDa subunit 15 74954416-74957464 Enzymes, Predicted intracellular proteins Evidence at protein level HPA046900 Approved Supported Nucleoplasm
Microtubule organizing center Glioma:3.67e-5 (unfavourable) Expressed in all Mixed ovary: 12.2 DMTN DMT, EPB49 ENSG00000158856 Dematin actin binding protein 8 22048995-22082527 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA024290 Uncertain Renal cancer:3.85e-9 (favourable), Glioma:4.61e-5 (unfavourable) Expressed in all Expressed in all cerebral cortex: 222.1 MED10 L6, MGC5309, NUT2, TRG20 ENSG00000133398 Mediator complex subunit 10 5 6371881-6378594 Predicted intracellular proteins Evidence at protein level HPA042795, HPA054188 Supported Nucleoplasm Liver cancer:1.62e-6 (unfavourable), Renal cancer:2.19e-5 (unfavourable), Glioma:4.81e-5 (unfavourable) Expressed in all Expressed in all cerebral cortex: 44.9 ZNF420 FLJ32191 ENSG00000197050 Zinc finger protein 420 19 37007857-37130314 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA053022, HPA059675 Approved Approved Nucleoplasm Glioma:4.88e-5 (favourable), Renal cancer:1.83e-4 (favourable) Expressed in all Mixed testis: 18.4 CD81 TAPA-1, TAPA1, TSPAN28 ENSG00000110651 CD81 molecule 11 2376177-2397419 CD markers, Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB002507, HPA007234 Supported Supported Plasma membrane Glioma:5.12e-5 (unfavourable), Pancreatic cancer:3.86e-4 (favourable), Colorectal cancer:7.56e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 2246.2 TSPAN13 NET-6, TM4SF13 ENSG00000106537 Tetraspanin 13 7 16753535-16784536 Predicted membrane proteins Evidence at protein level HPA007426 Uncertain Approved Nucleus Glioma:5.27e-5 (unfavourable), Ovarian cancer:2.20e-4 (favourable), Renal cancer:2.43e-4 (unfavourable), Liver cancer:2.94e-4 (unfavourable) Expressed in all Expressed in all lung: 246.3 RRAGB ENSG00000083750 Ras-related GTP binding B X 55717739-55758774 Predicted intracellular proteins Evidence at protein level HPA003734 Approved Approved Golgi apparatus
Vesicles Lung cancer:3.64e-6 (favourable), Glioma:5.36e-5 (favourable), Colorectal cancer:7.60e-4 (unfavourable) Expressed in all Expressed in all epididymis: 41.5 ZBED6CL C7orf29 ENSG00000188707 ZBED6 C-terminal like 7 150329789-150332721 Predicted intracellular proteins Evidence at transcript level HPA019724, HPA055805 Approved Approved Nuclear membrane
Vesicles Renal cancer:1.38e-5 (unfavourable), Pancreatic cancer:2.44e-5 (favourable), Glioma:5.65e-5 (unfavourable), Breast cancer:9.48e-5 (favourable) Expressed in all Tissue enhanced adrenal gland: 31.9;parathyroid gland: 30.0 lymph node: 10.0 HPCAL1 BDR1, HLP2, VILIP-3 ENSG00000115756 Hippocalcin-like 1 2 10302889-10427617 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA043245 Approved Renal cancer:4.39e-6 (unfavourable), Glioma:5.68e-5 (unfavourable) Expressed in all Expressed in all lung: 80.8 CTF1 CT-1, CT1 ENSG00000150281 Cardiotrophin 1 16 30896607-30903560 Predicted intracellular proteins Evidence at protein level CAB025853 Uncertain Glioma:5.72e-5 (unfavourable), Lung cancer:9.87e-4 (favourable) Expressed in all Mixed parathyroid gland: 28.1 ZFP1 FLJ34243, ZNF475 ENSG00000184517 ZFP1 zinc finger protein 16 75148492-75172236 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA044916, HPA062910 Uncertain Approved Nucleus Glioma:5.81e-5 (favourable), Stomach cancer:9.80e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 25.1 RP11-195F19.5 ENSG00000187186 9 34664163-34666112 Predicted intracellular proteins Evidence at protein level HPA069617 Supported Approved Nucleoli
Endoplasmic reticulum
Vesicles Glioma:5.81e-5 (unfavourable) Mixed Tissue enriched 5 testis: 139.6 cerebral cortex: 25.8 WFDC2 dJ461P17.6, EDDM4, HE4, WAP5 ENSG00000101443 WAP four-disulfide core domain 2 20 45469706-45481532 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA042302 Supported Approved Cytosol Renal cancer:4.44e-5 (favourable), Glioma:5.87e-5 (unfavourable) Expressed in all Tissue enriched 6 cervix, uterine: 6507.3 seminal vesicle: 1038.0 GHDC LGP1 ENSG00000167925 GH3 domain containing 17 42188799-42194532 Plasma proteins, Predicted secreted proteins Evidence at protein level HPA031650 Uncertain Renal cancer:2.00e-6 (favourable), Glioma:5.91e-5 (unfavourable), Endometrial cancer:3.21e-4 (favourable), Ovarian cancer:5.20e-4 (unfavourable) Expressed in all Expressed in all spleen: 29.8 RRAS ENSG00000126458 Related RAS viral (r-ras) oncogene homolog 19 49635292-49640201 Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB010160, HPA060364, CAB069439 Uncertain Approved Vesicles Renal cancer:1.54e-9 (unfavourable), Glioma:6.03e-5 (unfavourable), Lung cancer:5.28e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 206.9 CEND1 BM88, FLJ90066 ENSG00000184524 Cell cycle exit and neuronal differentiation 1 11 787104-790123 Predicted membrane proteins Evidence at protein level HPA042527 Supported Approved Mitochondria Glioma:6.10e-5 (unfavourable) Tissue enriched Tissue enriched 16 cerebral cortex: 114.3 adrenal gland: 7.1 PXN ENSG00000089159 Paxillin 12 120210439-120265771 Predicted intracellular proteins Evidence at protein level CAB003841, HPA051309 Supported Validated Focal adhesion sites
Cytosol Head and neck cancer:3.72e-5 (unfavourable), Glioma:6.11e-5 (unfavourable), Liver cancer:7.12e-5 (unfavourable), Lung cancer:1.73e-4 (unfavourable) Expressed in all Expressed in all placenta: 112.3 CARD19 bA370F5.1, BinCARD, C9orf89, MGC11115 ENSG00000165233 Caspase recruitment domain family, member 19 9 93096218-93113283 Predicted membrane proteins Evidence at protein level HPA010921, HPA010990, HPA038297 Approved Supported Mitochondria Liver cancer:1.32e-5 (unfavourable), Glioma:6.41e-5 (unfavourable) Expressed in all Mixed testis: 11.2 PATZ1 dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG ENSG00000100105 POZ (BTB) and AT hook containing zinc finger 1 22 31325804-31346232 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA047893, HPA048315 Approved Supported Nucleoplasm Renal cancer:8.54e-8 (favourable), Urothelial cancer:7.79e-6 (favourable), Glioma:6.53e-5 (favourable), Lung cancer:8.71e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 39.8 DNAJC30 WBSCR18 ENSG00000176410 DnaJ (Hsp40) homolog, subfamily C, member 30 7 73680969-73683453 Predicted membrane proteins Evidence at protein level HPA017318 Uncertain Supported Renal cancer:4.91e-8 (favourable), Glioma:6.59e-5 (unfavourable) Expressed in all Expressed in all testis: 11.3 TCAF2 FAM115C, FAM139A, FLJ40722 ENSG00000170379 TRPM8 channel-associated factor 2 7 143620950-143730409 Enzymes, Predicted intracellular proteins Evidence at protein level HPA038756, HPA038758 Uncertain Supported Endoplasmic reticulum
Plasma membrane
Cell Junctions Renal cancer:4.17e-6 (unfavourable), Glioma:6.78e-5 (unfavourable) Mixed Mixed placenta: 8.4 NEUROD1 BETA2, BHF-1, bHLHa3, MODY6, NEUROD ENSG00000162992 Neuronal differentiation 1 2 181673088-181680876 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003278, CAB022450 Approved Glioma:6.83e-5 (favourable) Tissue enhanced Tissue enhanced cerebral cortex: 6.0;duodenum: 6.2;small intestine: 4.5;stomach: 4.9 pancreas: 1.8 TBL1XR1 C21, DC42, FLJ12894, IRA1, TBLR1 ENSG00000177565 Transducin (beta)-like 1 X-linked receptor 1 3 177019355-177197396 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019182 Supported Approved Nucleoplasm Liver cancer:1.08e-7 (unfavourable), Renal cancer:4.25e-5 (unfavourable), Glioma:7.23e-5 (favourable) Expressed in all Expressed in all thyroid gland: 61.2 ZNF639 ANC-2H01, ZASC1 ENSG00000121864 Zinc finger protein 639 3 179322991-179338583 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA049023, HPA052163 Uncertain Supported Nucleoplasm Glioma:7.36e-5 (favourable), Liver cancer:2.13e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 68.7 PTPRN2 IA-2beta, ICAAR, KIAA0387, phogrin ENSG00000155093 Protein tyrosine phosphatase, receptor type, N polypeptide 2 7 157539056-158587788 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006900, HPA026656 Approved Uncertain Vesicles
Plasma membrane Glioma:7.72e-5 (unfavourable), Renal cancer:8.68e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 82.5 stomach: 39.0 TXNDC11 EFP1 ENSG00000153066 Thioredoxin domain containing 11 16 11679080-11742878 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA041174, HPA041390 Supported Supported Plasma membrane
Cytosol Endometrial cancer:2.12e-5 (favourable), Glioma:8.01e-5 (unfavourable) Expressed in all Expressed in all parathyroid gland: 83.0 KDELR2 ELP-1, ERD2.2 ENSG00000136240 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 7 6445953-6484242 Predicted membrane proteins Evidence at protein level HPA016459 Approved Renal cancer:6.79e-8 (unfavourable), Head and neck cancer:1.03e-5 (unfavourable), Glioma:8.16e-5 (unfavourable) Expressed in all Expressed in all placenta: 202.3 MTHFD2 ENSG00000065911 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 74198562-74217565 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB003684, HPA049657 Approved Renal cancer:1.11e-16 (unfavourable), Endometrial cancer:2.07e-5 (unfavourable), Glioma:8.47e-5 (favourable) Expressed in all Expressed in all appendix: 40.7 MGAT4B GnT-Ivb ENSG00000161013 Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 5 179797597-179806952 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA052134 Uncertain Glioma:8.53e-5 (unfavourable), Renal cancer:5.78e-4 (favourable) Expressed in all Expressed in all small intestine: 314.0 SPAG4 CT127, SUN4 ENSG00000061656 Sperm associated antigen 4 20 35615892-35621049 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA048393, HPA061789 Approved Endometrial cancer:9.52e-8 (favourable), Colorectal cancer:1.09e-5 (unfavourable), Glioma:8.89e-5 (unfavourable), Renal cancer:1.28e-4 (unfavourable), Urothelial cancer:6.66e-4 (favourable) Expressed in all Mixed testis: 22.6 ZFP37 ZNF906 ENSG00000136866 ZFP37 zinc finger protein 9 113038380-113056759 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA049112 Uncertain Approved Nucleus
Vesicles Glioma:9.22e-5 (favourable) Mixed Mixed ovary: 8.8 BET1 hbet1 ENSG00000105829 Bet1 golgi vesicular membrane trafficking protein 7 93962762-94004382 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Glioma:9.38e-5 (unfavourable), Renal cancer:1.32e-4 (unfavourable) Expressed in all Expressed in all placenta: 51.4 STC1 STC ENSG00000159167 Stanniocalcin 1 8 23841915-23854807 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB018625, HPA023918 Approved Renal cancer:1.23e-6 (unfavourable), Glioma:9.44e-5 (unfavourable), Lung cancer:1.53e-4 (unfavourable), Stomach cancer:5.55e-4 (unfavourable), Head and neck cancer:6.32e-4 (unfavourable), Cervical cancer:8.45e-4 (unfavourable) Expressed in all Tissue enhanced cervix, uterine: 77.7 endometrium: 53.9 PAK1 ENSG00000149269 P21 protein (Cdc42/Rac)-activated kinase 1 11 77321707-77474635 Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA003565, CAB005312 Supported Supported Validated Plasma membrane
Cytosol Glioma:9.48e-5 (unfavourable), Colorectal cancer:5.87e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 186.8 EID3 FLJ25832, NSE4B, NSMCE4B ENSG00000255150 EP300 interacting inhibitor of differentiation 3 12 104303739-104305202 Predicted intracellular proteins Evidence at protein level HPA059367 Uncertain Supported Nucleus
Nucleoli Renal cancer:5.96e-5 (unfavourable), Glioma:9.70e-5 (unfavourable) Mixed Tissue enriched 14 testis: 111.7 seminal vesicle: 7.7 HRASLS5 HRLP5 ENSG00000168004 HRAS-like suppressor family, member 5 11 63461404-63491194 Predicted intracellular proteins Evidence at protein level Glioma:9.80e-5 (unfavourable) Mixed Tissue enriched 5 testis: 95.8 adipose tissue: 17.7 SNX10 ENSG00000086300 Sorting nexin 10 7 26291895-26374329 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA015605, HPA064782 Approved Approved Nucleus
Nucleoli
Microtubules Renal cancer:8.06e-5 (unfavourable), Glioma:9.81e-5 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 94.6 lung: 60.7 MANBA ENSG00000109323 Mannosidase, beta A, lysosomal 4 102631488-102760994 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level HPA053478 Approved Supported Vesicles Liver cancer:3.74e-6 (unfavourable), Glioma:1.06e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 36.8 SMPD1 ASM ENSG00000166311 Sphingomyelin phosphodiesterase 1, acid lysosomal 11 6390431-6394998 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Renal cancer:4.57e-6 (favourable), Glioma:1.09e-4 (unfavourable), Pancreatic cancer:7.47e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 62.3 AEBP1 ACLP ENSG00000106624 AE binding protein 1 7 44104361-44114562 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB009966, HPA047724, HPA063595, HPA064970 Supported Supported Nucleoplasm
Vesicles
Cytosol Renal cancer:9.31e-9 (unfavourable), Glioma:1.10e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 297.8 ZNF253 BMZF-1, FLJ90391, ZNF411 ENSG00000256771 Zinc finger protein 253 19 19865886-19894674 Predicted intracellular proteins, Transcription factors Evidence at transcript level Renal cancer:9.69e-5 (favourable), Glioma:1.11e-4 (favourable), Ovarian cancer:2.19e-4 (favourable) Expressed in all Mixed thyroid gland: 25.8 VILL ENSG00000136059 Villin-like 3 37988059-38007188 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA035675 Supported Glioma:1.16e-4 (unfavourable), Head and neck cancer:1.75e-4 (favourable) Tissue enhanced Tissue enhanced stomach: 94.8 small intestine: 69.1 IMPDH1 LCA11, RP10, sWSS2608 ENSG00000106348 IMP (inosine 5'-monophosphate) dehydrogenase 1 7 128392277-128410252 Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level HPA001400 Approved Supported Cytosol
Rods & Rings Renal cancer:1.78e-12 (unfavourable), Liver cancer:1.12e-7 (unfavourable), Urothelial cancer:3.72e-5 (unfavourable), Glioma:1.17e-4 (unfavourable), Cervical cancer:3.87e-4 (unfavourable) Expressed in all Expressed in all appendix: 47.2 PGBD5 DKFZp761A0620, FLJ11413 ENSG00000177614 PiggyBac transposable element derived 5 1 230314482-230425729 Predicted intracellular proteins Evidence at protein level HPA065010 Approved Nucleoplasm Glioma:1.20e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 40.2;cervix, uterine: 28.9 adrenal gland: 12.7 RHBDD2 NPD007, RHBDL7 ENSG00000005486 Rhomboid domain containing 2 7 75842602-75888926 Enzymes, Predicted membrane proteins Evidence at protein level HPA045074, HPA051960 Uncertain Validated Golgi apparatus Renal cancer:8.68e-6 (favourable), Colorectal cancer:3.31e-5 (unfavourable), Glioma:1.25e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 253.1 ETNPPL AGXT2L1 ENSG00000164089 Ethanolamine-phosphate phospho-lyase 4 108742040-108763054 Enzymes, Predicted intracellular proteins Evidence at protein level HPA044546, HPA072938 Approved Approved Nucleus Glioma:1.31e-4 (favourable) Group enriched Group enriched 8 cerebral cortex: 141.6;liver: 98.5 stomach: 14.7 PCSK1 NEC1, PC1, PC3, SPC3 ENSG00000175426 Proprotein convertase subtilisin/kexin type 1 5 96390415-96434143 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA048564 Approved Glioma:1.31e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 33.7 adrenal gland: 8.3 LOXL1 LOL, LOXL ENSG00000129038 Lysyl oxidase-like 1 15 73925989-73952137 Disease related genes, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA042111, HPA063583 Approved Approved Endoplasmic reticulum Glioma:1.33e-4 (unfavourable) Expressed in all Mixed seminal vesicle: 16.4 SOX21 SOX25 ENSG00000125285 SRY (sex determining region Y)-box 21 13 94709622-94712399 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA064084 Approved Nucleus Glioma:1.34e-4 (favourable), Cervical cancer:7.60e-4 (favourable) Tissue enhanced Group enriched 6 cerebral cortex: 18.0;esophagus: 6.9;skin: 19.4;stomach: 33.9 tonsil: 3.2 PABPC1 PAB1, PABP1, PABPC2, PABPL1 ENSG00000070756 Poly(A) binding protein, cytoplasmic 1 8 100685816-100722809 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB011536, HPA045423, HPA067156 Supported Supported Cytosol Renal cancer:5.70e-12 (unfavourable), Glioma:1.35e-4 (favourable), Liver cancer:5.80e-4 (unfavourable) Expressed in all Expressed in all esophagus: 1155.5 SIMC1 C5orf25, FLJ44216, OOMA1, PLEIAD ENSG00000170085 SUMO-interacting motifs containing 1 5 176238367-176345991 Predicted intracellular proteins Evidence at protein level HPA037889, HPA037890 Approved Supported Nucleus
Nucleoli fibrillar center Endometrial cancer:2.32e-6 (unfavourable), Glioma:1.41e-4 (unfavourable) Expressed in all Tissue enhanced testis: 71.4 ovary: 58.5 KPNA3 hSRP1, IPOA4, SRP1gamma, SRP4 ENSG00000102753 Karyopherin alpha 3 (importin alpha 4) 13 49699307-49792921 Predicted intracellular proteins, Transporters Evidence at protein level HPA046852 Approved Approved Nucleoplasm
Cytosol Glioma:1.48e-4 (favourable), Cervical cancer:2.80e-4 (unfavourable), Renal cancer:3.81e-4 (unfavourable) Expressed in all Expressed in all testis: 49.6 MARS2 mtMetRS, SPAX3 ENSG00000247626 Methionyl-tRNA synthetase 2, mitochondrial 2 197705369-197708387 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA035589, HPA035590 Uncertain Approved Intermediate filaments
Cytosol Renal cancer:6.14e-5 (favourable), Glioma:1.49e-4 (favourable), Endometrial cancer:3.50e-4 (unfavourable) Expressed in all Expressed in all lymph node: 7.6 PDGFA PDGF-A, PDGF1 ENSG00000197461 Platelet-derived growth factor alpha polypeptide 7 497258-520296 Cancer-related genes, Candidate cardiovascular disease genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB005579 Uncertain Approved Vesicles
Microtubule organizing center Glioma:1.51e-4 (unfavourable), Head and neck cancer:1.78e-4 (unfavourable), Urothelial cancer:8.67e-4 (unfavourable) Expressed in all Expressed in all placenta: 39.1 C7orf31 ENSG00000153790 Chromosome 7 open reading frame 31 7 25134697-25180356 Predicted intracellular proteins Evidence at protein level HPA020346 Approved Nucleoplasm
Mitochondria Glioma:1.52e-4 (unfavourable) Expressed in all Tissue enriched 14 testis: 130.7 parathyroid gland: 9.4 PRSS12 BSSP-3, MRT1 ENSG00000164099 Protease, serine, 12 (neurotrypsin, motopsin) 4 118280038-118353003 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level HPA035054, HPA035055 Uncertain Approved Nucleus
Actin filaments Head and neck cancer:1.03e-4 (favourable), Glioma:1.53e-4 (favourable) Mixed Mixed cervix, uterine: 22.3 CLEC18B ENSG00000140839 C-type lectin domain family 18, member B 16 74408270-74421953 Predicted secreted proteins Evidence at transcript level HPA048976 Uncertain Glioma:1.55e-4 (unfavourable) Group enriched Group enriched 10 kidney: 30.8;testis: 8.2 cerebral cortex: 2.0 ZNF821 ENSG00000102984 Zinc finger protein 821 16 71859680-71895336 Predicted intracellular proteins Evidence at protein level HPA036372, HPA042742 Approved Supported Nucleoplasm
Nuclear speckles Renal cancer:6.32e-10 (favourable), Pancreatic cancer:4.27e-5 (favourable), Glioma:1.55e-4 (favourable) Expressed in all Tissue enhanced testis: 33.3 cerebral cortex: 13.7 CHI3L2 YKL-39, YKL39 ENSG00000064886 Chitinase 3-like 2 1 111200771-111243440 Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA005443 Uncertain Renal cancer:8.59e-7 (unfavourable), Glioma:1.55e-4 (unfavourable), Head and neck cancer:2.19e-4 (favourable) Tissue enriched Tissue enhanced appendix: 156.7 tonsil: 107.4 CYGB HGB, STAP ENSG00000161544 Cytoglobin 17 76527356-76551175 Predicted intracellular proteins Evidence at protein level HPA017757, HPA061642 Approved Validated Nuclear speckles Endometrial cancer:2.55e-5 (favourable), Glioma:1.63e-4 (unfavourable), Renal cancer:2.13e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 46.6 ADAMTSL4 DKFZP434K1772, TSRC1 ENSG00000143382 ADAMTS-like 4 1 150549369-150560937 Disease related genes, Predicted secreted proteins Evidence at protein level HPA006279 Approved Approved Plasma membrane
Cytosol Renal cancer:4.35e-7 (unfavourable), Glioma:1.63e-4 (unfavourable), Colorectal cancer:1.86e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 89.1 lung: 32.7 UBXN10 FLJ25429, UBXD3 ENSG00000162543 UBX domain protein 10 1 20186085-20196048 Predicted intracellular proteins Evidence at protein level HPA028555, HPA028564 Uncertain Uncertain Nucleoplasm
Plasma membrane
Cell Junctions Glioma:1.64e-4 (unfavourable), Endometrial cancer:2.02e-4 (favourable) Mixed Tissue enhanced fallopian tube: 78.2 testis: 25.4 TAX1BP3 TIP-1 ENSG00000213977 Tax1 (human T-cell leukemia virus type I) binding protein 3 17 3662896-3668682 Predicted intracellular proteins Evidence at protein level HPA046410, HPA063078 Approved Approved Nucleoli fibrillar center
Vesicles
Actin filaments Glioma:1.66e-4 (unfavourable), Lung cancer:1.76e-4 (unfavourable), Renal cancer:7.90e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 226.7 MAP3K6 ASK2, MAPKKK6, MEKK6 ENSG00000142733 Mitogen-activated protein kinase kinase kinase 6 1 27355184-27366892 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA051192 Approved Approved Nucleus
Plasma membrane
Actin filaments
Cytosol Glioma:1.73e-4 (unfavourable), Head and neck cancer:7.26e-4 (favourable), Liver cancer:8.76e-4 (unfavourable) Expressed in all Tissue enhanced skin: 114.6 esophagus: 41.3 ZNF322 bA457M11.2, bA457M11.3, HCG12, ZNF322A, ZNF388, ZNF489 ENSG00000181315 Zinc finger protein 322 6 26634383-26659752 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043161, HPA046692 Approved Supported Nucleus
Centrosome
Cytosol Glioma:1.75e-4 (favourable), Lung cancer:8.57e-4 (favourable) Expressed in all Mixed parathyroid gland: 28.7 LOXL2 WS9-14 ENSG00000134013 Lysyl oxidase-like 2 8 23297189-23425328 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB025848, HPA036257, HPA056542 Approved Approved Nucleoplasm Lung cancer:1.46e-7 (unfavourable), Renal cancer:2.91e-7 (unfavourable), Cervical cancer:9.83e-6 (unfavourable), Glioma:1.78e-4 (unfavourable), Pancreatic cancer:9.05e-4 (unfavourable) Expressed in all Tissue enhanced smooth muscle: 58.8 placenta: 53.0 LITAF FLJ38636, PIG7, SIMPLE, TP53I7 ENSG00000189067 Lipopolysaccharide-induced TNF factor 16 11547722-11636381 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006960 Approved Supported Nucleoplasm
Vesicles
Cytosol Glioma:1.78e-4 (unfavourable), Testis cancer:6.25e-4 (unfavourable) Expressed in all Expressed in all appendix: 231.9 EPS8L2 FLJ21935, FLJ22171, MGC3088 ENSG00000177106 EPS8-like 2 11 694438-727727 Predicted intracellular proteins Evidence at protein level HPA041143 Approved Supported Plasma membrane
Cytosol Glioma:1.80e-4 (unfavourable) Expressed in all Mixed small intestine: 112.7 ALG1L ALG1L1 ENSG00000189366 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 3 125929275-125937039 Predicted intracellular proteins Evidence at transcript level HPA036108 Uncertain Glioma:1.82e-4 (favourable), Urothelial cancer:6.24e-4 (favourable) Expressed in all Tissue enhanced epididymis: 12.5;urinary bladder: 15.4 skin: 6.8 CCDC74A FLJ40345 ENSG00000163040 Coiled-coil domain containing 74A 2 131527675-131533666 Predicted intracellular proteins Evidence at transcript level HPA060727 Uncertain Vesicles Renal cancer:1.70e-7 (unfavourable), Glioma:1.82e-4 (unfavourable), Testis cancer:4.92e-4 (favourable), Breast cancer:5.11e-4 (favourable) Mixed Tissue enhanced fallopian tube: 54.5;testis: 79.2 parathyroid gland: 26.7 IL4I1 FIG1 ENSG00000104951 Interleukin 4 induced 1 19 49889654-49929539 Enzymes, Predicted secreted proteins Evidence at protein level HPA045598 Supported Renal cancer:1.23e-10 (unfavourable), Glioma:1.85e-4 (unfavourable) Expressed in all Tissue enhanced appendix: 25.3;testis: 31.9 lymph node: 10.6 ARHGAP12 FLJ10971, FLJ20737, FLJ21785 ENSG00000165322 Rho GTPase activating protein 12 10 31805404-31928876 Predicted intracellular proteins Evidence at protein level HPA000412 Approved Renal cancer:4.64e-5 (favourable), Glioma:1.88e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 44.4 B4GALT7 beta4Gal-T7, XGALT-1 ENSG00000027847 Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 5 177600100-177610347 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA042330 Supported Glioma:1.90e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 27.2 EMP2 XMP ENSG00000213853 Epithelial membrane protein 2 16 10528422-10580698 Disease related genes, Predicted membrane proteins Evidence at protein level HPA014711 Approved Approved Nucleoplasm
Cytosol Renal cancer:2.85e-8 (unfavourable), Glioma:1.93e-4 (unfavourable) Expressed in all Tissue enhanced lung: 344.5 skin: 166.7 SLC2A6 GLUT6, GLUT9, HSA011372 ENSG00000160326 Solute carrier family 2 (facilitated glucose transporter), member 6 9 133471095-133479137 Predicted membrane proteins, Transporters Evidence at protein level HPA042272, CAB046014 Uncertain Renal cancer:1.02e-11 (unfavourable), Glioma:1.94e-4 (unfavourable), Liver cancer:8.82e-4 (unfavourable) Expressed in all Mixed appendix: 6.3 ERLIN2 C8orf2, Erlin-2, NET32, SPFH2, SPG18 ENSG00000147475 ER lipid raft associated 2 8 37736599-37759101 Disease related genes, Predicted secreted proteins Evidence at protein level HPA002025, CAB014894 Supported Supported Endoplasmic reticulum Renal cancer:6.67e-6 (favourable), Glioma:1.96e-4 (unfavourable), Colorectal cancer:5.16e-4 (favourable) Expressed in all Expressed in all thyroid gland: 80.6 PRNP AltPrP, CD230, CJD, GSS, PRIP, PRP ENSG00000171867 Prion protein 20 4686236-4701590 CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA042754, HPA043398 Supported Approved Nuclear membrane
Vesicles
Cytosol Liver cancer:7.41e-5 (unfavourable), Glioma:1.99e-4 (unfavourable), Colorectal cancer:2.96e-4 (unfavourable), Endometrial cancer:4.64e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 621.3 LGR6 FLJ14471 ENSG00000133067 Leucine-rich repeat containing G protein-coupled receptor 6 1 202193901-202319781 G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA008556 Approved Approved Nucleoplasm
Plasma membrane Glioma:2.00e-4 (unfavourable) Tissue enhanced Tissue enhanced fallopian tube: 14.1 gallbladder: 9.6 FBXO17 FBG4, Fbx17, FBXO26, FLJ11798, FLJ25205, MGC9379 ENSG00000269190 F-box protein 17 19 38941401-38975910 Predicted intracellular proteins Evidence at protein level Glioma:2.10e-4 (unfavourable), Endometrial cancer:5.67e-4 (unfavourable), Stomach cancer:5.91e-4 (unfavourable) Mixed Mixed kidney: 14.4 CDYL CDYL1, DKFZP586C1622 ENSG00000153046 Chromodomain protein, Y-like 6 4706159-4955551 Enzymes, Predicted intracellular proteins Evidence at protein level CAB012249, HPA035577, HPA035578 Supported Validated Nucleoplasm
Nuclear speckles Glioma:2.10e-4 (favourable), Liver cancer:2.20e-4 (unfavourable), Melanoma:7.52e-4 (unfavourable) Expressed in all Expressed in all placenta: 27.5 SLC19A2 THTR1, TRMA ENSG00000117479 Solute carrier family 19 (thiamine transporter), member 2 1 169463909-169486003 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA006119, HPA016599 Uncertain Approved Cytosol Renal cancer:2.70e-5 (favourable), Glioma:2.11e-4 (favourable), Breast cancer:8.41e-4 (favourable) Expressed in all Expressed in all gallbladder: 49.3 NSUN5 FLJ10267, NOL1R, NSUN5A, p120(NOL1), WBSCR20, WBSCR20A, Ynl022cL ENSG00000130305 NOP2/Sun domain family, member 5 7 73302517-73308867 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA020536, HPA045590, HPA046867 Approved Validated Nucleus
Nucleoli Glioma:2.11e-4 (unfavourable), Liver cancer:3.96e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 26.0 ENO1 ENO1L1, MBP-1, MPB1, PPH ENSG00000074800 Enolase 1, (alpha) 1 8861002-8879249 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB018614, HPA068284, CAB069394 Supported Validated Nucleoplasm
Plasma membrane
Cytosol Liver cancer:1.30e-8 (unfavourable), Glioma:2.12e-4 (unfavourable) Expressed in all Expressed in all appendix: 789.1 FLNC ABP-280, ABPL, FLN2 ENSG00000128591 Filamin C, gamma 7 128830377-128859274 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006135 Supported Supported Plasma membrane
Cytosol Lung cancer:2.17e-5 (unfavourable), Urothelial cancer:3.73e-5 (unfavourable), Glioma:2.14e-4 (unfavourable), Renal cancer:5.69e-4 (unfavourable) Expressed in all Tissue enhanced skeletal muscle: 384.8 smooth muscle: 158.7 G0S2 ENSG00000123689 G0/G1 switch 2 1 209675420-209676388 Predicted intracellular proteins Evidence at protein level Glioma:2.22e-4 (unfavourable), Renal cancer:3.14e-4 (unfavourable), Colorectal cancer:7.72e-4 (unfavourable) Expressed in all Group enriched 5 adipose tissue: 956.4;bone marrow: 939.4;skeletal muscle: 240.6 appendix: 140.8 HS3ST2 3OST2 ENSG00000122254 Heparan sulfate (glucosamine) 3-O-sulfotransferase 2 16 22814177-22916338 Enzymes, Predicted intracellular proteins Evidence at protein level HPA017736 Approved Renal cancer:1.35e-4 (favourable), Glioma:2.22e-4 (unfavourable) Mixed Tissue enriched 30 cerebral cortex: 35.8 lung: 1.1 NACAD KIAA0363 ENSG00000136274 NAC alpha domain containing 7 45080438-45088914 Predicted intracellular proteins Evidence at protein level HPA020981 Approved Approved Nucleus
Cytosol Glioma:2.23e-4 (unfavourable) Group enriched Tissue enriched 6 cerebral cortex: 48.9 ovary: 7.6 PHGDH PDG, PGDH, SERA ENSG00000092621 Phosphoglycerate dehydrogenase 1 119659798-119744215 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB003681, HPA021241, HPA024031, CAB068216 Supported Validated Nucleoplasm
Plasma membrane
Cytosol Endometrial cancer:1.48e-4 (unfavourable), Glioma:2.26e-4 (favourable) Expressed in all Tissue enhanced parathyroid gland: 212.4 skin: 116.1 EDN3 ET3 ENSG00000124205 Endothelin 3 20 59300427-59325992 Disease related genes, Predicted secreted proteins Evidence at protein level Glioma:2.38e-4 (favourable) Mixed Tissue enhanced duodenum: 39.3;small intestine: 40.2 thyroid gland: 36.2 ZDHHC24 ENSG00000174165 Zinc finger, DHHC-type containing 24 11 66520637-66546238 Enzymes, Predicted membrane proteins Evidence at protein level HPA016619 Approved Approved Vesicles
Cytosol Glioma:2.39e-4 (unfavourable) Expressed in all Mixed parathyroid gland: 10.9 SCX bHLHa41, bHLHa48, SCXA, SCXB ENSG00000260428 Scleraxis bHLH transcription factor 8 144266560-144268481 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA043183 Uncertain Glioma:2.46e-4 (unfavourable) Group enriched Tissue enhanced skeletal muscle: 5.3 parathyroid gland: 3.3 FOSL1 fra-1 ENSG00000175592 FOS-like antigen 1 11 65892049-65900573 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004396, HPA066901 Uncertain Validated Nucleoplasm Renal cancer:6.40e-6 (unfavourable), Pancreatic cancer:9.26e-5 (unfavourable), Lung cancer:1.95e-4 (unfavourable), Head and neck cancer:2.05e-4 (unfavourable), Glioma:2.46e-4 (unfavourable) Expressed in all Tissue enhanced adipose tissue: 35.2;gallbladder: 51.8 urinary bladder: 27.7 OPN3 ECPN, encephalopsin, ERO, NMO-1, PPP1R116 ENSG00000054277 Opsin 3 1 241590102-241677376 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB013682, HPA064443 Uncertain Approved Nucleoplasm Cervical cancer:3.17e-5 (unfavourable), Glioma:2.51e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 26.8 lung: 12.7 MXRA5 DKFZp564I1922 ENSG00000101825 Matrix-remodelling associated 5 X 3308565-3346641 Cancer-related genes, Disease related genes, Predicted secreted proteins Evidence at protein level HPA000508 Uncertain Uncertain Mitochondria Glioma:2.56e-4 (unfavourable), Urothelial cancer:8.94e-4 (unfavourable) Expressed in all Tissue enhanced cervix, uterine: 56.8 skin: 35.3 TSPAN4 NAG-2, TETRASPAN, TM4SF7, TSPAN-4 ENSG00000214063 Tetraspanin 4 11 842808-867116 Predicted membrane proteins Evidence at protein level Liver cancer:1.02e-4 (unfavourable), Glioma:2.57e-4 (unfavourable) Expressed in all Expressed in all spleen: 107.3 SPSB4 SSB-4 ENSG00000175093 SplA/ryanodine receptor domain and SOCS box containing 4 3 141051402-141148611 Predicted intracellular proteins Evidence at protein level HPA073015 Approved Nucleoplasm
Plasma membrane Glioma:2.57e-4 (favourable) Group enriched Tissue enhanced cerebral cortex: 1.3;spleen: 1.5;testis: 2.4 pancreas: 1.2 MAP2K1 MAPKK1, MEK1, PRKMK1 ENSG00000169032 Mitogen-activated protein kinase kinase 1 15 66386817-66492312 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB003834, HPA026430 Approved Validated Plasma membrane
Cytosol Glioma:2.68e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 144.8 FAHD2B DKFZp434N062 ENSG00000144199 Fumarylacetoacetate hydrolase domain containing 2B 2 97083583-97094882 Predicted intracellular proteins Evidence at protein level HPA042145, HPA044987 Approved Glioma:2.81e-4 (unfavourable) Mixed Expressed in all epididymis: 47.9 NCOA4 ARA70, DKFZp762E1112, ELE1, PTC3, RFG ENSG00000266412 Nuclear receptor coactivator 4 10 46005088-46030714 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA051260, HPA065208 Uncertain Approved Nucleoli
Golgi apparatus
Cytosol Renal cancer:8.04e-6 (favourable), Glioma:2.88e-4 (favourable) Expressed in all Expressed in all duodenum: 253.9 HOXB2 HOX2, HOX2H ENSG00000173917 Homeobox B2 17 48540894-48544989 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA047857 Supported Nucleus Glioma:3.01e-4 (unfavourable) Expressed in all Tissue enhanced epididymis: 56.0 cervix, uterine: 24.6 SUPT3H SPT3, SPT3L ENSG00000196284 SPT3 homolog, SAGA and STAGA complex component 6 44809317-45377953 Predicted intracellular proteins Evidence at protein level HPA024371 Supported Supported Nucleoplasm Ovarian cancer:1.72e-4 (favourable), Glioma:3.05e-4 (favourable) Expressed in all Mixed prostate: 14.2 SEMA4F SEMAM, SEMAW ENSG00000135622 Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 2 74654228-74683853 Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA065969 Approved Nucleus
Plasma membrane
Centrosome Renal cancer:9.74e-6 (unfavourable), Endometrial cancer:5.94e-5 (unfavourable), Glioma:3.18e-4 (unfavourable), Thyroid cancer:6.94e-4 (favourable) Expressed in all Mixed cerebral cortex: 14.2 FHL5 ACT, dJ393D12.2, FLJ33049 ENSG00000112214 Four and a half LIM domains 5 6 96562548-96616636 Predicted intracellular proteins Evidence at protein level Glioma:3.18e-4 (favourable) Mixed Tissue enhanced testis: 105.8 cervix, uterine: 43.1 RAB3D D2-2, GOV, RAB16, RAD3D ENSG00000105514 RAB3D, member RAS oncogene family 19 11322046-11346270 Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB018067, HPA063283 Approved Approved Vesicles Glioma:3.30e-4 (unfavourable) Expressed in all Tissue enhanced skin: 62.7 esophagus: 28.2 CEP57 KIAA0092, Translokin, TSP57 ENSG00000166037 Centrosomal protein 57kDa 11 95789965-95832693 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA018315 Approved Supported Microtubules
Cytosol Glioma:3.33e-4 (favourable) Expressed in all Expressed in all testis: 53.8 ETNK2 EKI2, FLJ10761 ENSG00000143845 Ethanolamine kinase 2 1 204131062-204152003 Enzymes, Predicted intracellular proteins Evidence at protein level HPA057167 Supported Glioma:3.43e-4 (unfavourable), Renal cancer:6.50e-4 (favourable) Expressed in all Tissue enhanced kidney: 109.8;liver: 119.6;testis: 142.1 ovary: 43.3 REEP2 C5orf19, SGC32445, SPG72 ENSG00000132563 Receptor accessory protein 2 5 138439017-138446969 Disease related genes, Predicted membrane proteins Evidence at protein level HPA031813 Supported Breast cancer:7.83e-5 (favourable), Glioma:3.43e-4 (unfavourable), Melanoma:9.31e-4 (favourable) Tissue enriched Tissue enriched 5 cerebral cortex: 90.3 smooth muscle: 17.8 NAGLU NAG ENSG00000108784 N-acetylglucosaminidase, alpha 17 42536172-42544449 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA038815 Supported Approved Renal cancer:2.58e-6 (favourable), Glioma:3.43e-4 (unfavourable), Endometrial cancer:4.17e-4 (favourable), Pancreatic cancer:6.90e-4 (favourable) Expressed in all Expressed in all thyroid gland: 47.4 SARDH DMGDHL1, SDH ENSG00000123453 Sarcosine dehydrogenase 9 133663560-133739955 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA057267, HPA058086 Supported Approved Mitochondria Glioma:3.50e-4 (unfavourable) Tissue enriched Tissue enhanced epididymis: 58.4;liver: 43.2 kidney: 12.5 COL22A1 ENSG00000169436 Collagen, type XXII, alpha 1 8 138588235-138914006 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA024830 Approved Supported Endoplasmic reticulum
Vesicles Lung cancer:2.13e-6 (unfavourable), Glioma:3.62e-4 (unfavourable) Mixed Tissue enhanced adrenal gland: 9.8 prostate: 4.8 ULBP2 RAET1H ENSG00000131015 UL16 binding protein 2 6 149942000-149949235 Predicted membrane proteins Evidence at protein level CAB018974 Approved Supported Vesicles
Plasma membrane Glioma:3.69e-4 (unfavourable), Cervical cancer:8.07e-4 (unfavourable) Expressed in all Mixed cerebral cortex,esophagus: 3.0 CCM2 C7orf22, MGC4607, OSM ENSG00000136280 Cerebral cavernous malformation 2 7 44999475-45076469 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA020273, HPA021669, HPA065815 Supported Validated Mitochondria Renal cancer:5.06e-7 (unfavourable), Pancreatic cancer:1.16e-4 (favourable), Colorectal cancer:1.79e-4 (unfavourable), Glioma:3.77e-4 (unfavourable) Expressed in all Expressed in all lymph node: 49.8 SIL1 BAP, MSS, ULG5 ENSG00000120725 SIL1 nucleotide exchange factor 5 138946720-139293557 Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA011949 Supported Glioma:3.77e-4 (unfavourable), Endometrial cancer:4.34e-4 (favourable) Expressed in all Expressed in all thyroid gland: 59.8 KCNN4 hIKCa1, hKCa4, hSK4, IK, KCa3.1 ENSG00000104783 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 19 43766533-43781257 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA053841, HPA059622 Approved Renal cancer:1.05e-14 (unfavourable), Urothelial cancer:1.75e-4 (favourable), Glioma:3.77e-4 (unfavourable), Pancreatic cancer:4.56e-4 (unfavourable) Expressed in all Tissue enhanced salivary gland: 74.3 stomach: 37.1 SCHIP1 SCHIP-1 ENSG00000151967 Schwannomin interacting protein 1 3 159839861-159897360 Predicted intracellular proteins Evidence at protein level HPA003243 Uncertain Approved Cytosol Glioma:3.78e-4 (favourable) Tissue enriched Tissue enhanced cerebral cortex: 103.2;heart muscle: 52.0 skeletal muscle: 25.5 SLC46A1 HCP1, MGC9564, PCFT ENSG00000076351 Solute carrier family 46 (folate transporter), member 1 17 28394756-28407197 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB011614 Approved Supported Plasma membrane
Cytosol Glioma:3.90e-4 (unfavourable) Expressed in all Expressed in all duodenum: 97.7 MSTN GDF8 ENSG00000138379 Myostatin 2 190055697-190062729 Disease related genes, Predicted secreted proteins Evidence at protein level CAB009963 Approved Glioma:3.98e-4 (favourable) Tissue enriched Tissue enhanced skeletal muscle: 3.4 cerebral cortex,endometrium: 1.3 C10orf107 bA63A2.1, Em:AC022398.2, MGC44593 ENSG00000183346 Chromosome 10 open reading frame 107 10 61662961-61766766 Predicted intracellular proteins Evidence at protein level HPA041398 Supported Uncertain Nucleoplasm
Centrosome
Cytosol Endometrial cancer:1.79e-4 (favourable), Glioma:3.99e-4 (unfavourable) Mixed Tissue enhanced fallopian tube: 43.7;testis: 30.2 parathyroid gland: 12.4 RNF175 FLJ34190 ENSG00000145428 Ring finger protein 175 4 153710125-153760235 Predicted membrane proteins Evidence at protein level HPA035837 Uncertain Glioma:4.15e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 13.2 seminal vesicle: 4.8 GNS ENSG00000135677 Glucosamine (N-acetyl)-6-sulfatase 12 64713445-64759447 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA013695, CAB026011, HPA048508 Supported Liver cancer:1.94e-5 (unfavourable), Glioma:4.17e-4 (unfavourable) Expressed in all Expressed in all adrenal gland: 173.8 DYNLT3 TCTE1L, TCTEX1L ENSG00000165169 Dynein, light chain, Tctex-type 3 X 37836757-37847637 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA003938 Approved Glioma:4.22e-4 (unfavourable) Expressed in all Expressed in all adrenal gland: 77.5 ZNF274 ZKSCAN19, ZSCAN51 ENSG00000171606 Zinc finger protein 274 19 58183029-58213562 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA028880 Uncertain Supported Nucleus
Centrosome Prostate cancer:1.75e-4 (unfavourable), Glioma:4.26e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 39.6 SEPT2 DIFF6, hNedd5, KIAA0158, NEDD5, Pnutl3 ENSG00000168385 Septin 2 2 241315100-241354027 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB017190, HPA018481 Supported Supported Nucleus
Actin filaments
Cytosol Liver cancer:3.66e-4 (unfavourable), Glioma:4.32e-4 (favourable) Expressed in all Expressed in all thyroid gland: 368.1 RGS4 SCZD9 ENSG00000117152 Regulator of G-protein signaling 4 1 163068775-163076802 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA030802 Approved Endoplasmic reticulum Stomach cancer:1.92e-4 (unfavourable), Renal cancer:3.97e-4 (unfavourable), Glioma:4.33e-4 (unfavourable) Expressed in all Tissue enriched 5 cerebral cortex: 289.9 adrenal gland: 54.3 SMAD9 MADH6, MADH9 ENSG00000120693 SMAD family member 9 13 36844831-36920765 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB009119, HPA031162 Approved Supported Nucleoplasm
Cytosol Glioma:4.39e-4 (favourable), Thyroid cancer:4.92e-4 (unfavourable) Mixed Tissue enhanced thyroid gland: 62.6 prostate: 22.6 VGF SCG7, SgVII ENSG00000128564 VGF nerve growth factor inducible 7 101162509-101165593 Plasma proteins, Predicted secreted proteins Evidence at protein level HPA055177, HPA072505 Supported Supported Vesicles Endometrial cancer:4.25e-4 (unfavourable), Glioma:4.43e-4 (unfavourable) Tissue enriched Tissue enriched 22 cerebral cortex: 46.2 adipose tissue: 2.0 TOLLIP IL-1RAcPIP ENSG00000078902 Toll interacting protein 11 1274371-1309654 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA038621, HPA038622 Supported Approved Plasma membrane
Cytosol Renal cancer:1.11e-16 (favourable), Glioma:4.57e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 132.7 ABCB9 EST122234 ENSG00000150967 ATP-binding cassette, sub-family B (MDR/TAP), member 9 12 122920951-122981649 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB033052, HPA035113, HPA035114 Approved Supported Vesicles Glioma:4.62e-4 (unfavourable) Mixed Tissue enhanced testis: 23.9 cerebral cortex: 12.1 PNPLA4 DXS1283E, GS2, iPLA2eta ENSG00000006757 Patatin-like phospholipase domain containing 4 X 7898247-7927739 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA003656 Approved Renal cancer:2.23e-12 (favourable), Glioma:4.67e-4 (unfavourable), Head and neck cancer:5.37e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 50.3 TBPL1 STUD, TLF, TLP, TRF2 ENSG00000028839 TBP-like 1 6 133952170-133990432 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA071810, HPA071813 Approved Validated Nucleoplasm
Nucleoli Liver cancer:7.91e-5 (unfavourable), Renal cancer:4.14e-4 (unfavourable), Glioma:4.67e-4 (favourable), Pancreatic cancer:7.23e-4 (favourable) Expressed in all Tissue enriched 8 testis: 226.1 thyroid gland: 28.1 EFCAB7 KIAA1799, RP4-534K7.1 ENSG00000203965 EF-hand calcium binding domain 7 1 63523372-63572693 Predicted intracellular proteins Evidence at protein level HPA029611, HPA029612, HPA029613 Supported Approved Nucleus
Nucleoli
Plasma membrane
Cytosol Glioma:4.84e-4 (favourable) Mixed Mixed testis: 24.5 CTSL CTSL1, FLJ31037 ENSG00000135047 Cathepsin L 9 87725519-87731393 Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level CAB000459 Supported Lung cancer:5.15e-5 (unfavourable), Renal cancer:4.34e-4 (favourable), Glioma:4.94e-4 (unfavourable) Expressed in all Expressed in all placenta: 744.0 DENND2A FAM31D, KIAA1277 ENSG00000146966 DENN/MADD domain containing 2A 7 140518420-140673993 Predicted intracellular proteins Evidence at protein level HPA021778, HPA026718 Approved Renal cancer:3.05e-6 (unfavourable), Glioma:4.97e-4 (unfavourable), Colorectal cancer:9.35e-4 (favourable) Tissue enriched Mixed endometrium: 31.8 STAC2 24b2 ENSG00000141750 SH3 and cysteine rich domain 2 17 39210536-39225872 Predicted intracellular proteins Evidence at protein level HPA017288 Approved Nucleoplasm
Vesicles Endometrial cancer:4.05e-5 (unfavourable), Glioma:5.04e-4 (unfavourable), Ovarian cancer:6.66e-4 (unfavourable) Group enriched Group enriched 6 breast: 31.7;cerebral cortex: 30.2;epididymis: 14.8;seminal vesicle: 35.5 skin: 4.5 NMB MGC17211, MGC2277, MGC3936 ENSG00000197696 Neuromedin B 15 84655129-84658563 Predicted secreted proteins Evidence at protein level CAB019302 Approved Approved Nucleus
Vesicles
Plasma membrane Renal cancer:2.25e-4 (unfavourable), Glioma:5.07e-4 (favourable) Expressed in all Tissue enhanced adipose tissue: 46.1;cerebral cortex: 47.3 thyroid gland: 14.7 IFI44L C1orf29, GS3686 ENSG00000137959 Interferon-induced protein 44-like 1 78619922-78646145 Predicted intracellular proteins Evidence at protein level HPA053247, HPA060372 Approved Approved Nucleoplasm Renal cancer:1.06e-4 (unfavourable), Endometrial cancer:2.95e-4 (unfavourable), Glioma:5.08e-4 (favourable) Expressed in all Mixed spleen: 32.9 ITPKA IP3-3KA, IP3KA ENSG00000137825 Inositol-trisphosphate 3-kinase A 15 41493393-41503551 Enzymes, Predicted intracellular proteins Evidence at protein level HPA040454 Approved Approved Approved Vesicles Renal cancer:3.76e-9 (unfavourable), Glioma:5.08e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 25.8;duodenum: 18.2;small intestine: 20.2 stomach: 9.1 GLUD1 GDH, GLUD ENSG00000148672 Glutamate dehydrogenase 1 10 87050486-87094866 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level HPA042492, HPA044839, HPA061369 Approved Supported Mitochondria Renal cancer:1.44e-6 (favourable), Pancreatic cancer:1.76e-5 (unfavourable), Glioma:5.08e-4 (favourable) Expressed in all Expressed in all liver: 457.5 FOXN2 HTLF ENSG00000170802 Forkhead box N2 2 48314637-48379294 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003485 Supported Supported Nucleus
Vesicles Renal cancer:2.81e-5 (unfavourable), Glioma:5.14e-4 (favourable) Expressed in all Expressed in all bone marrow: 36.5 POR CYPOR, FLJ26468 ENSG00000127948 P450 (cytochrome) oxidoreductase 7 75899200-75986855 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB004372, HPA010136 Supported Approved Nucleoplasm
Vesicles
Cytosol Glioma:5.23e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 219.8 AP3S1 CLAPS3 ENSG00000177879 Adaptor-related protein complex 3, sigma 1 subunit 5 115841481-115914081 Predicted intracellular proteins Evidence at protein level HPA049270 Uncertain Approved Vesicles Renal cancer:9.57e-8 (unfavourable), Pancreatic cancer:1.13e-5 (unfavourable), Breast cancer:1.22e-4 (unfavourable), Glioma:5.30e-4 (unfavourable) Expressed in all Expressed in all epididymis: 39.1 LOXL4 FLJ21889, LOXC ENSG00000138131 Lysyl oxidase-like 4 10 98247690-98268250 Predicted secreted proteins Evidence at protein level CAB033876, HPA037609 Approved Approved Vesicles Glioma:5.36e-4 (unfavourable), Ovarian cancer:9.57e-4 (unfavourable) Expressed in all Mixed cervix, uterine: 17.7 CAMKMT C2orf34, CLNMT ENSG00000143919 Calmodulin-lysine N-methyltransferase 2 44361950-44772592 Enzymes, Predicted intracellular proteins Evidence at protein level HPA067912 Supported Nucleus Glioma:5.39e-4 (favourable) Expressed in all Expressed in all testis: 24.4 HIST3H2A MGC3165 ENSG00000181218 Histone cluster 3, H2a 1 228456979-228457873 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA041189 Supported Glioma:5.44e-4 (favourable) Expressed in all Tissue enhanced adrenal gland: 22.8 cerebral cortex: 10.7 FAM35A bA163M19.1, FAM35A1, MGC5560 ENSG00000122376 Family with sequence similarity 35, member A 10 87094161-87191468 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA036582 Uncertain Approved Nucleoplasm
Actin filaments Glioma:5.44e-4 (favourable), Colorectal cancer:6.06e-4 (favourable) Expressed in all Expressed in all thyroid gland: 38.6 GOLT1A CGI-141, FLJ42654, GOT1, MGC62027, YMR292W ENSG00000174567 Golgi transport 1A 1 204198160-204214092 Predicted membrane proteins Evidence at protein level Renal cancer:6.35e-5 (unfavourable), Urothelial cancer:1.51e-4 (favourable), Glioma:5.49e-4 (unfavourable) Tissue enriched Tissue enhanced duodenum: 41.5;liver: 78.8;small intestine: 43.2 parathyroid gland: 27.5 HPS1 BLOC3S1, HPS ENSG00000107521 Hermansky-Pudlak syndrome 1 10 98416198-98446947 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA061260 Approved Endometrial cancer:2.93e-5 (favourable), Cervical cancer:3.37e-5 (favourable), Lung cancer:1.26e-4 (favourable), Glioma:5.53e-4 (unfavourable) Expressed in all Expressed in all lymph node: 24.6 PRICKLE1 EPM1B., FLJ31937, RILP ENSG00000139174 Prickle homolog 1 12 42456754-42590355 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA001379, HPA050037 Approved Approved Nucleoplasm Glioma:5.56e-4 (unfavourable) Mixed Mixed spleen: 24.0 FN3KRP FLJ12171, FN3KL ENSG00000141560 Fructosamine 3 kinase related protein 17 82716683-82730328 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA056172, HPA065831 Approved Approved Nucleoplasm Glioma:5.57e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 49.0 BCL3 BCL4, D19S37 ENSG00000069399 B-cell CLL/lymphoma 3 19 44747705-44760044 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB002051, HPA047514 Approved Supported Nucleoplasm
Vesicles
Midbody Renal cancer:3.13e-14 (unfavourable), Melanoma:3.74e-4 (favourable), Glioma:5.58e-4 (unfavourable), Breast cancer:9.67e-4 (favourable) Expressed in all Expressed in all appendix: 30.9 EIF4H KIAA0038, WBSCR1, WSCR1 ENSG00000106682 Eukaryotic translation initiation factor 4H 7 74174245-74197101 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA030542 Approved Approved Nucleoplasm
Nuclear bodies
Cytosol Head and neck cancer:2.15e-4 (unfavourable), Glioma:5.65e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 249.7 GPC5 ENSG00000179399 Glypican 5 13 91398607-92873682 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA040152, HPA044081 Supported Approved Nucleus
Cytosol Glioma:5.67e-4 (unfavourable) Tissue enhanced Tissue enhanced cerebral cortex: 15.9;kidney: 8.1;testis: 11.5 lung: 4.9 ASNSD1 FLJ20752, NBLA00058, NS3TP1 ENSG00000138381 Asparagine synthetase domain containing 1 2 189661385-189670831 Predicted intracellular proteins Evidence at protein level HPA036132, HPA036133, HPA075042 Uncertain Approved Cytosol Glioma:5.68e-4 (favourable), Liver cancer:8.66e-4 (unfavourable) Expressed in all Expressed in all placenta: 50.9 MYLK2 KMLC, MLCK2, skMLCK ENSG00000101306 Myosin light chain kinase 2 20 31819308-31834689 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA059704, HPA059890 Approved Supported Endoplasmic reticulum Glioma:5.74e-4 (favourable) Tissue enhanced Tissue enriched 49 skeletal muscle: 253.2 esophagus: 5.1 CASC10 bA418C1.3, C10orf114 ENSG00000204682 Cancer susceptibility candidate 10 10 21492658-21497262 Predicted intracellular proteins Evidence at transcript level HPA064131 Uncertain Approved Nucleoplasm Glioma:5.81e-4 (unfavourable), Urothelial cancer:5.86e-4 (unfavourable) Mixed Mixed placenta: 4.0 B3GAT3 GlcAT-I ENSG00000149541 Beta-1,3-glucuronyltransferase 3 11 62615296-62622175 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA051328 Approved Liver cancer:5.11e-6 (unfavourable), Glioma:5.96e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 37.0 GJB2 CX26, DFNA3, DFNB1, NSRD1 ENSG00000165474 Gap junction protein, beta 2, 26kDa 13 20187470-20192898 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB013093, HPA014362 Uncertain Approved Mitochondria Renal cancer:2.53e-6 (unfavourable), Pancreatic cancer:2.90e-4 (unfavourable), Glioma:5.98e-4 (unfavourable), Lung cancer:6.25e-4 (unfavourable) Expressed in all Tissue enriched 9 esophagus: 728.4 tonsil: 84.8 CRELD1 AVSD2 ENSG00000163703 Cysteine-rich with EGF-like domains 1 3 9933822-9945413 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA026964 Uncertain Approved Nucleoli
Cytosol Glioma:6.05e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 65.6 ADRA1B ENSG00000170214 Adrenoceptor alpha 1B 5 159916783-159972544 Cancer-related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA074416 Supported Plasma membrane Renal cancer:1.40e-6 (unfavourable), Thyroid cancer:3.19e-5 (favourable), Endometrial cancer:6.00e-5 (unfavourable), Ovarian cancer:2.67e-4 (favourable), Glioma:6.07e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 14.8;spleen: 17.3 ovary: 4.8 HEPH CPL, KIAA0698 ENSG00000089472 Hephaestin X 66162549-66268867 Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA005824 Approved Renal cancer:7.00e-6 (unfavourable), Glioma:6.23e-4 (unfavourable) Expressed in all Mixed smooth muscle: 117.4 SSC4D S4D-SRCRB, SRCRB-S4D, SRCRB4D ENSG00000146700 Scavenger receptor cysteine rich family, 4 domains 7 76389334-76409695 Predicted secreted proteins Evidence at transcript level HPA062611 Uncertain Endometrial cancer:2.83e-6 (unfavourable), Renal cancer:4.71e-4 (unfavourable), Glioma:6.31e-4 (unfavourable) Mixed Group enriched 5 kidney: 1.4;parathyroid gland: 4.1;thyroid gland: 2.0 cervix, uterine: 0.5 ZNF708 KOX8, ZNF15, ZNF15L1 ENSG00000182141 Zinc finger protein 708 19 21221500-21329425 Predicted intracellular proteins, Transcription factors Evidence at protein level Ovarian cancer:3.53e-4 (favourable), Glioma:6.32e-4 (favourable) Expressed in all Mixed cerebral cortex: 17.8 SLC9A1 APNH, NHE1, PPP1R143 ENSG00000090020 Solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1 27098815-27166981 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB022371, HPA048532, HPA052891 Supported Supported Plasma membrane Glioma:6.32e-4 (unfavourable), Ovarian cancer:7.10e-4 (unfavourable) Expressed in all Expressed in all stomach: 66.4 GRN CLN11, PCDGF, PGRN ENSG00000030582 Granulin 17 44345086-44353102 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA008763, CAB019394, HPA028747 Approved Validated Endoplasmic reticulum
Endosomes
Lysosomes Glioma:6.36e-4 (unfavourable) Expressed in all Expressed in all lung: 425.0 CEPT1 ENSG00000134255 Choline/ethanolamine phosphotransferase 1 1 111139627-111185102 Enzymes, Predicted membrane proteins Evidence at protein level Glioma:6.43e-4 (favourable) Expressed in all Expressed in all spleen: 41.5 ZKSCAN3 ZF47, Zfp47, ZNF306, ZNF309, ZSCAN35 ENSG00000189298 Zinc finger with KRAB and SCAN domains 3 6 28349914-28369177 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA009637 Approved Supported Nucleoplasm Glioma:6.55e-4 (favourable) Expressed in all Mixed parathyroid gland: 9.9 AC087350.1 ENSG00000281527 8 116849884-116851073 Predicted intracellular proteins Evidence at transcript level Renal cancer:4.09e-9 (unfavourable), Prostate cancer:1.12e-4 (unfavourable), Glioma:6.57e-4 (favourable) Expressed in all Tissue enhanced bone marrow: 88.0 appendix: 29.7 WBSCR16 ENSG00000274523 Williams-Beuren syndrome chromosome region 16 7 75027122-75074228 Predicted intracellular proteins Evidence at protein level HPA052184, HPA060643 Approved Approved Nucleus
Cytosol Glioma:6.65e-4 (unfavourable) Expressed in all Expressed in all skeletal muscle: 36.4 IGFBP6 ENSG00000167779 Insulin-like growth factor binding protein 6 12 53097436-53102345 Plasma proteins, Predicted secreted proteins Evidence at protein level HPA008005 Uncertain Glioma:6.66e-4 (unfavourable) Expressed in all Tissue enhanced adipose tissue: 72.2 cervix, uterine: 47.7 POLDIP3 KIAA1649, PDIP46 ENSG00000100227 Polymerase (DNA-directed), delta interacting protein 3 22 42583721-42614962 Predicted intracellular proteins Evidence at protein level HPA018419, HPA048790 Approved Validated Nuclear speckles
Cytoplasmic bodies Renal cancer:3.36e-4 (favourable), Glioma:6.67e-4 (favourable) Expressed in all Expressed in all ovary: 109.4 FAM110C ENSG00000184731 Family with sequence similarity 110, member C 2 38814-46870 Predicted intracellular proteins Evidence at protein level HPA036144, HPA036145 Uncertain Glioma:6.77e-4 (unfavourable) Mixed Mixed seminal vesicle: 28.8 RARRES2 HP10433, TIG2 ENSG00000106538 Retinoic acid receptor responder (tazarotene induced) 2 7 150338317-150341674 Plasma proteins, Predicted secreted proteins Evidence at protein level HPA049359 Uncertain Cytosol Renal cancer:6.83e-4 (unfavourable), Glioma:6.90e-4 (unfavourable) Expressed in all Tissue enhanced adrenal gland: 1529.4 parathyroid gland: 904.5 MTHFS HsT19268 ENSG00000136371 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 15 79833585-79897379 Enzymes, Predicted intracellular proteins Evidence at protein level HPA008067, HPA054177 Approved Supported Cytosol Liver cancer:1.29e-6 (favourable), Renal cancer:2.04e-4 (favourable), Glioma:6.94e-4 (unfavourable) Expressed in all Expressed in all liver: 115.9 EPHB6 HEP ENSG00000106123 EPH receptor B6 7 142855061-142871094 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA035784 Approved Nuclear speckles Urothelial cancer:4.68e-5 (favourable), Cervical cancer:1.80e-4 (favourable), Glioma:6.96e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 22.6;skin: 25.0 cervix, uterine: 7.5 GDI2 RABGDIB ENSG00000057608 GDP dissociation inhibitor 2 10 5765223-5842132 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA049290, HPA057668 Supported Liver cancer:7.56e-7 (unfavourable), Glioma:7.00e-4 (favourable) Expressed in all Expressed in all lymph node: 244.2 HGSNAT FLJ32731, HGNAT, TMEM76 ENSG00000165102 Heparan-alpha-glucosaminide N-acetyltransferase 8 43140455-43202855 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA029578 Approved Ovarian cancer:6.33e-5 (favourable), Glioma:7.02e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 50.4 SMAGP hSMAGP, MGC149453, MGC149454 ENSG00000170545 Small cell adhesion glycoprotein 12 51244558-51270890 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA039711 Approved Supported Nucleoplasm
Plasma membrane Renal cancer:2.24e-4 (favourable), Pancreatic cancer:4.38e-4 (unfavourable), Glioma:7.05e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 144.1 esophagus: 83.7 COL16A1 ENSG00000084636 Collagen, type XVI, alpha 1 1 31652247-31704319 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA027235, HPA027237 Approved Golgi apparatus
Plasma membrane
Cytosol Renal cancer:4.00e-9 (unfavourable), Glioma:7.08e-4 (unfavourable) Expressed in all Tissue enhanced ovary: 181.4 cervix, uterine: 127.5 MSC ABF-1, bHLHa22 ENSG00000178860 Musculin 8 71841549-71844468 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062878 Supported Nucleoplasm Renal cancer:1.07e-13 (unfavourable), Liver cancer:4.83e-5 (unfavourable), Glioma:7.15e-4 (unfavourable) Expressed in all Mixed placenta: 22.6 ACHE YT ENSG00000087085 Acetylcholinesterase (Yt blood group) 7 100889994-100896974 Blood group antigen proteins, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA019704, HPA027098 Approved Golgi apparatus
Vesicles Renal cancer:3.88e-5 (unfavourable), Glioma:7.16e-4 (unfavourable) Mixed Tissue enhanced skeletal muscle: 58.5 cerebral cortex: 14.1 RWDD2A dJ747H23.2, MGC13523, RWDD2 ENSG00000013392 RWD domain containing 2A 6 83193379-83198932 Predicted intracellular proteins Evidence at protein level HPA030105, HPA030106, HPA030107 Uncertain Approved Vesicles Ovarian cancer:3.82e-5 (favourable), Pancreatic cancer:1.38e-4 (favourable), Glioma:7.17e-4 (favourable) Expressed in all Mixed prostate: 18.8 PDLIM2 ENSG00000120913 PDZ and LIM domain 2 (mystique) 8 22578279-22598025 Predicted intracellular proteins Evidence at protein level HPA003880 Approved Approved Actin filaments
Focal adhesion sites Renal cancer:1.37e-7 (unfavourable), Glioma:7.23e-4 (unfavourable) Expressed in all Expressed in all spleen: 273.0 NDRG1 CAP43, DRG1, NDR1, RTP, TDD5 ENSG00000104419 N-myc downstream regulated 1 8 133237171-133302022 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006881 Approved Supported Microtubules
Cytosol Liver cancer:1.47e-4 (unfavourable), Renal cancer:4.13e-4 (unfavourable), Glioma:7.24e-4 (unfavourable) Expressed in all Expressed in all prostate: 487.4 DTX2 KIAA1528, RNF58 ENSG00000091073 Deltex 2, E3 ubiquitin ligase 7 76461676-76505995 Predicted intracellular proteins Evidence at protein level HPA042931 Approved Supported Nucleoplasm
Nuclear membrane Renal cancer:1.13e-8 (unfavourable), Glioma:7.25e-4 (unfavourable) Expressed in all Expressed in all esophagus: 37.3 SEZ6L2 FLJ90517, PSK-1 ENSG00000174938 Seizure related 6 homolog (mouse)-like 2 16 29871159-29899547 Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA064471 Approved Colorectal cancer:1.31e-4 (unfavourable), Glioma:7.27e-4 (unfavourable), Cervical cancer:7.46e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 82.7;parathyroid gland: 57.3 adrenal gland: 30.8 ARHGEF7 BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB ENSG00000102606 Rho guanine nucleotide exchange factor (GEF) 7 13 111114559-111305737 Predicted intracellular proteins Evidence at protein level HPA004744 Approved Glioma:7.29e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 97.1 SLC35F2 FLJ13018 ENSG00000110660 Solute carrier family 35, member F2 11 107790991-107928293 Predicted membrane proteins, Transporters Evidence at protein level HPA048185, HPA050695 Uncertain Approved Mitochondria Pancreatic cancer:5.92e-6 (unfavourable), Lung cancer:4.03e-4 (unfavourable), Glioma:7.31e-4 (favourable) Expressed in all Mixed prostate: 33.0 KCTD20 C6orf69, dJ108K11.3, MGC14254 ENSG00000112078 Potassium channel tetramerization domain containing 20 6 36442767-36491143 Predicted intracellular proteins Evidence at protein level HPA030092 Approved Approved Nuclear speckles
Endoplasmic reticulum Glioma:7.39e-4 (favourable), Renal cancer:8.02e-4 (unfavourable), Liver cancer:8.32e-4 (unfavourable), Thyroid cancer:9.31e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 46.7 SLC47A2 FLJ31196, MATE2, MATE2-K ENSG00000180638 Solute carrier family 47 (multidrug and toxin extrusion), member 2 17 19678288-19718979 Predicted membrane proteins, Transporters Evidence at protein level Glioma:7.41e-4 (unfavourable) Tissue enhanced Group enriched 5 fallopian tube: 16.0;kidney: 48.9 epididymis: 6.0 QPRT QPRTase ENSG00000103485 Quinolinate phosphoribosyltransferase 16 29679008-29698699 Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA011887 Approved Breast cancer:5.10e-5 (unfavourable), Glioma:7.45e-4 (unfavourable) Expressed in all Expressed in all kidney: 111.8 MFSD9 MGC11332 ENSG00000135953 Major facilitator superfamily domain containing 9 2 102715840-102736888 Predicted membrane proteins Evidence at protein level HPA055293, HPA061859 Approved Approved Nucleoli Glioma:7.48e-4 (unfavourable) Expressed in all Mixed duodenum: 10.1 ANKH ANK, CCAL2, CMDJ, CPPDD, HANK ENSG00000154122 ANKH inorganic pyrophosphate transport regulator 5 14704804-14871778 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA068104 Approved Cytosol Glioma:7.64e-4 (unfavourable) Expressed in all Expressed in all prostate: 49.5 NRP1 CD304, NRP, VEGF165R ENSG00000099250 Neuropilin 1 10 33177492-33336262 Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB004511, HPA030278 Approved Uncertain Mitochondria Stomach cancer:1.22e-5 (unfavourable), Cervical cancer:7.10e-5 (unfavourable), Renal cancer:3.87e-4 (unfavourable), Glioma:7.78e-4 (unfavourable) Expressed in all Expressed in all placenta: 193.5 ATP6AP1 16A, Ac45, ATP6IP1, ATP6S1, CF2, ORF, VATPS1, XAP-3, XAP3 ENSG00000071553 ATPase, H+ transporting, lysosomal accessory protein 1 X 154428632-154436516 Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB015218 Uncertain Approved Plasma membrane
Microtubules
Cytosol Renal cancer:5.26e-8 (favourable), Breast cancer:2.40e-4 (unfavourable), Glioma:7.82e-4 (unfavourable), Pancreatic cancer:7.83e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 205.5 FBXO27 Fbg5, Fbx27 ENSG00000161243 F-box protein 27 19 38990714-39032785 Predicted intracellular proteins Evidence at protein level HPA046800, HPA062242 Approved Approved Nucleoplasm Endometrial cancer:3.53e-5 (unfavourable), Breast cancer:2.15e-4 (favourable), Glioma:7.83e-4 (unfavourable) Mixed Tissue enhanced skin: 22.8 esophagus: 8.5 MOB2 HCCA2 ENSG00000182208 MOB kinase activator 2 11 1469457-1501247 Predicted intracellular proteins Evidence at protein level HPA046313 Uncertain Supported Nucleus
Nucleoli
Cytosol Renal cancer:2.02e-4 (favourable), Glioma:7.86e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 35.2 AGFG1 HRB, RAB, RIP ENSG00000173744 ArfGAP with FG repeats 1 2 227472152-227561214 Predicted intracellular proteins Evidence at protein level HPA008741 Approved Supported Vesicles Liver cancer:7.31e-6 (unfavourable), Ovarian cancer:3.43e-5 (unfavourable), Lung cancer:1.85e-4 (unfavourable), Renal cancer:6.92e-4 (unfavourable), Cervical cancer:7.13e-4 (unfavourable), Glioma:7.89e-4 (favourable) Expressed in all Expressed in all testis: 168.4 ATF7IP FLJ10688, p621 ENSG00000171681 Activating transcription factor 7 interacting protein 12 14365632-14502935 Predicted intracellular proteins Evidence at protein level HPA016578, HPA023505 Supported Validated Nucleoplasm
Nuclear bodies Glioma:7.91e-4 (favourable) Expressed in all Expressed in all testis: 61.7 SERGEF DelGEF, Gnefr ENSG00000129158 Secretion regulating guanine nucleotide exchange factor 11 17788048-18013162 Predicted intracellular proteins Evidence at protein level HPA037811, HPA037812, HPA074086 Supported Validated Nucleoplasm
Vesicles
Cytosol Glioma:7.92e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 52.7 SDC1 CD138, SDC, SYND1, syndecan ENSG00000115884 Syndecan 1 2 20200797-20225433 Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level CAB002424, HPA006185 Approved Approved Focal adhesion sites Breast cancer:2.22e-4 (unfavourable), Glioma:8.05e-4 (unfavourable) Expressed in all Tissue enhanced esophagus: 251.7;skin: 288.6 liver: 144.9 FKBP9 FKBP60, FKBP63 ENSG00000122642 FK506 binding protein 9, 63 kDa 7 32957404-33006931 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA012595, HPA055256 Approved Approved Golgi apparatus
Vesicles
Mitochondria Urothelial cancer:7.02e-6 (unfavourable), Head and neck cancer:2.02e-4 (unfavourable), Cervical cancer:4.22e-4 (unfavourable), Glioma:8.06e-4 (unfavourable), Liver cancer:8.69e-4 (unfavourable) Expressed in all Expressed in all placenta: 109.6 BACE2 AEPLC, ALP56, CEAP1, DRAP ENSG00000182240 Beta-site APP-cleaving enzyme 2 21 41167801-41282518 Enzymes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB008975 Uncertain Cervical cancer:1.11e-4 (unfavourable), Glioma:8.13e-4 (unfavourable) Expressed in all Mixed stomach: 31.1 PYROXD2 C10orf33, FLJ23849 ENSG00000119943 Pyridine nucleotide-disulphide oxidoreductase domain 2 10 98383565-98415184 Predicted intracellular proteins Evidence at protein level HPA037566, HPA037567, HPA067394 Uncertain Approved Mitochondria Urothelial cancer:3.37e-4 (favourable), Glioma:8.17e-4 (unfavourable) Expressed in all Mixed fallopian tube: 15.2 NXPH4 NPH4 ENSG00000182379 Neurexophilin 4 12 57216795-57226449 Predicted secreted proteins Evidence at transcript level Renal cancer:7.68e-6 (unfavourable), Liver cancer:2.57e-4 (unfavourable), Endometrial cancer:6.21e-4 (unfavourable), Glioma:8.20e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 8.3;prostate: 6.7;skin: 12.2 placenta: 3.8 FAM19A3 TAFA-3 ENSG00000184599 Family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 1 112720419-112727235 Predicted secreted proteins Evidence at transcript level HPA055927 Approved Glioma:8.24e-4 (unfavourable) Mixed Group enriched 16 adrenal gland: 20.0;testis: 8.7 epididymis: 0.9 SYT5 ENSG00000129990 Synaptotagmin V 19 55171199-55180441 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Pancreatic cancer:5.54e-4 (favourable), Glioma:8.26e-4 (unfavourable) Mixed Tissue enriched 10 cerebral cortex: 131.7 adrenal gland: 12.8 TNFSF13 APRIL, CD256 ENSG00000161955 Tumor necrosis factor (ligand) superfamily, member 13 17 7558292-7561608 Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA004863 Uncertain Renal cancer:1.30e-9 (favourable), Glioma:8.28e-4 (unfavourable) Expressed in all Expressed in all lung: 150.0 ZNF618 KIAA1952, NEDD10 ENSG00000157657 Zinc finger protein 618 9 113876282-114056591 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA023116, HPA061732 Uncertain Approved Nucleoplasm Renal cancer:5.22e-7 (favourable), Glioma:8.34e-4 (unfavourable) Expressed in all Mixed parathyroid gland: 16.2 DNAJA4 PRO1472 ENSG00000140403 DnaJ (Hsp40) homolog, subfamily A, member 4 15 78264086-78282196 Predicted intracellular proteins Evidence at protein level CAB004646, HPA041790 Uncertain Approved Plasma membrane
Cytosol Renal cancer:1.08e-7 (favourable), Glioma:8.35e-4 (unfavourable) Expressed in all Expressed in all testis: 95.2 GALNT11 GalNAc-T11 ENSG00000178234 Polypeptide N-acetylgalactosaminyltransferase 11 7 152025674-152122347 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA039330 Uncertain Renal cancer:2.24e-6 (favourable), Glioma:8.42e-4 (unfavourable) Expressed in all Expressed in all kidney: 241.1 SLC12A5 KCC2, KIAA1176 ENSG00000124140 Solute carrier family 12 (potassium/chloride transporter), member 5 20 46021690-46060152 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA072058 Supported Glioma:8.45e-4 (unfavourable) Mixed Tissue enriched 8 cerebral cortex: 94.5 adrenal gland: 12.0 OBSL1 KIAA0657 ENSG00000124006 Obscurin-like 1 2 219550729-219571859 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA036404, HPA036405 Approved Approved Centrosome Glioma:8.52e-4 (unfavourable) Expressed in all Expressed in all ovary: 220.2 PDIA4 ERP70, ERP72 ENSG00000155660 Protein disulfide isomerase family A, member 4 7 149003062-149028641 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA006139, HPA006140, CAB017368 Supported Supported Endoplasmic reticulum Renal cancer:5.20e-9 (unfavourable), Glioma:8.61e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 371.2 HTRA1 ARMD7, HtrA, IGFBP5-protease, PRSS11 ENSG00000166033 HtrA serine peptidase 1 10 122461525-122514908 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA036655 Approved Supported Plasma membrane Renal cancer:7.90e-7 (unfavourable), Urothelial cancer:5.62e-6 (unfavourable), Glioma:8.66e-4 (unfavourable) Expressed in all Mixed ovary: 502.5 CMPK1 CMPK, UMP-CMPK ENSG00000162368 Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 1 47333797-47378839 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA053730, HPA058604 Approved Supported Nucleus Glioma:8.67e-4 (favourable) Expressed in all Expressed in all small intestine: 172.6 TMEM60 C7orf35, DC32 ENSG00000135211 Transmembrane protein 60 7 77793728-77798580 Predicted membrane proteins Evidence at transcript level HPA062625 Approved Breast cancer:3.09e-4 (favourable), Glioma:8.70e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 55.3 PLEKHG5 GEF720, KIAA0720, Syx, Tech ENSG00000171680 Pleckstrin homology domain containing, family G (with RhoGef domain) member 5 1 6466092-6520061 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA049570 Uncertain Approved Nucleus Glioma:8.72e-4 (unfavourable) Expressed in all Tissue enhanced skin: 111.2 spleen: 35.3 NTAN1 ENSG00000157045 N-terminal asparagine amidase 16 15037853-15056079 Predicted intracellular proteins Evidence at protein level HPA051418 Approved Nucleoplasm
Golgi apparatus Glioma:8.85e-4 (unfavourable), Stomach cancer:9.07e-4 (unfavourable) Expressed in all Expressed in all epididymis: 19.9 RASSF7 C11orf13, HRAS1, HRC1 ENSG00000099849 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 11 560404-564021 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA078015 Supported Microtubule organizing center Glioma:8.86e-4 (unfavourable) Expressed in all Mixed fallopian tube: 43.9 NME1-NME2 NM23-LV, NMELV ENSG00000011052 NME1-NME2 readthrough 17 51153590-51171744 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB002169, HPA008467, HPA041113 Approved Supported Cytosol Glioma:8.99e-4 (favourable) Expressed in all Expressed in all appendix: 50.0 ADAMTS15 ENSG00000166106 ADAM metallopeptidase with thrombospondin type 1 motif, 15 11 130448974-130476641 Enzymes, Predicted secreted proteins Evidence at transcript level HPA042867 Uncertain Approved Cytosol Urothelial cancer:5.63e-5 (unfavourable), Glioma:9.00e-4 (favourable), Lung cancer:9.72e-4 (unfavourable) Mixed Tissue enhanced adipose tissue: 30.2;placenta: 23.5 breast: 11.0 LSP1 WP34 ENSG00000130592 Lymphocyte-specific protein 1 11 1852970-1892267 Predicted intracellular proteins Evidence at protein level CAB017781, HPA019693, HPA071843 Supported Supported Plasma membrane Endometrial cancer:2.54e-4 (favourable), Cervical cancer:3.56e-4 (favourable), Glioma:9.00e-4 (unfavourable) Expressed in all Expressed in all spleen: 286.5 RGS14 ENSG00000169220 Regulator of G-protein signaling 14 5 177357837-177372601 Predicted intracellular proteins Evidence at protein level HPA046847, HPA061819 Approved Validated Nucleoplasm
Vesicles Liver cancer:1.84e-6 (unfavourable), Glioma:9.11e-4 (unfavourable) Expressed in all Mixed spleen: 22.1 GRIK1 GluK1, GLUR5 ENSG00000171189 Glutamate receptor, ionotropic, kainate 1 21 29536933-29940033 FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA014623 Uncertain Glioma:9.12e-4 (unfavourable) Group enriched Tissue enhanced adrenal gland: 16.8;cerebral cortex: 9.1 prostate: 3.9 SIRT3 SIR2L3 ENSG00000142082 Sirtuin 3 11 215458-236931 Predicted intracellular proteins Evidence at protein level HPA026809, CAB037142 Approved Renal cancer:4.85e-9 (favourable), Endometrial cancer:8.51e-5 (favourable), Pancreatic cancer:4.45e-4 (favourable), Glioma:9.21e-4 (unfavourable) Expressed in all Expressed in all epididymis: 49.8 DUSP3 VHR ENSG00000108861 Dual specificity phosphatase 3 17 43766121-43778988 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA063616 Supported Nucleoplasm
Cytosol Renal cancer:5.49e-5 (favourable), Head and neck cancer:3.00e-4 (unfavourable), Glioma:9.23e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 99.6 MKRN3 D15S9, MGC88288, RNF63, ZFP127, ZNF127 ENSG00000179455 Makorin ring finger protein 3 15 23565678-23630075 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA029494 Uncertain Approved Nucleoplasm
Plasma membrane
Cytosol Glioma:9.23e-4 (favourable) Mixed Tissue enhanced cerebral cortex: 5.9;placenta: 4.1;testis: 3.7 epididymis: 1.1 BMPR1A ACVRLK3, ALK3, CD292 ENSG00000107779 Bone morphogenetic protein receptor, type IA 10 86756650-86932838 Cancer-related genes, CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB019398 Approved Approved Cytosol Liver cancer:8.93e-4 (unfavourable), Glioma:9.38e-4 (favourable) Expressed in all Mixed thyroid gland: 33.8 OLFM1 AMY, NOE1, NOELIN, OlfA ENSG00000130558 Olfactomedin 1 9 135075243-135121179 Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA057444 Uncertain Approved Nucleus
Nucleoli
Cytosol Cervical cancer:7.14e-4 (favourable), Glioma:9.38e-4 (unfavourable) Expressed in all Tissue enriched 9 cerebral cortex: 732.4 epididymis: 85.0 VSNL1 HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1 ENSG00000163032 Visinin-like 1 2 17539126-17657018 Predicted intracellular proteins Evidence at protein level HPA053808 Approved Cytosol Glioma:9.39e-4 (unfavourable) Mixed Tissue enriched 14 cerebral cortex: 625.9 esophagus: 44.2 TMEM220 ENSG00000187824 Transmembrane protein 220 17 10699015-10730316 Predicted membrane proteins Evidence at protein level Liver cancer:2.23e-5 (favourable), Pancreatic cancer:1.72e-4 (favourable), Glioma:9.39e-4 (unfavourable) Expressed in all Expressed in all liver: 53.9 KHNYN KIAA0323 ENSG00000100441 KH and NYN domain containing 14 24429286-24441834 Predicted intracellular proteins Evidence at protein level HPA003402 Uncertain Approved Nucleoplasm
Cytosol Cervical cancer:4.38e-4 (unfavourable), Glioma:9.44e-4 (unfavourable) Expressed in all Expressed in all placenta: 48.7 PDZK1IP1 DD96, MAP17, SPAP ENSG00000162366 PDZK1 interacting protein 1 1 47183593-47191044 Predicted membrane proteins Evidence at protein level HPA014907 Approved Approved Nuclear speckles
Cytosol Pancreatic cancer:3.45e-4 (unfavourable), Glioma:9.46e-4 (unfavourable) Expressed in all Group enriched 6 gallbladder: 299.6;kidney: 1048.6 esophagus: 121.8 ZDHHC18 DKFZp667O2416 ENSG00000204160 Zinc finger, DHHC-type containing 18 1 26826710-26857602 Enzymes, Predicted membrane proteins Evidence at protein level HPA040234 Approved Approved Microtubules Renal cancer:1.36e-10 (unfavourable), Liver cancer:7.42e-7 (unfavourable), Glioma:9.53e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 75.3 MDK FLJ27379, MK, NEGF2 ENSG00000110492 Midkine (neurite growth-promoting factor 2) 11 46380756-46383837 Cancer-related genes, Predicted secreted proteins Evidence at protein level CAB010055, HPA057126 Uncertain Approved Vesicles Renal cancer:3.06e-6 (unfavourable), Glioma:9.54e-4 (unfavourable) Expressed in all Expressed in all ovary: 524.0 CHPF CHSY2, CSS2 ENSG00000123989 Chondroitin polymerizing factor 2 219538947-219543787 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA035123 Approved Supported Vesicles
Centrosome
Cytosol Cervical cancer:1.57e-4 (unfavourable), Head and neck cancer:1.68e-4 (unfavourable), Urothelial cancer:2.96e-4 (unfavourable), Glioma:9.56e-4 (unfavourable) Expressed in all Expressed in all testis: 77.4 THY1 CD90 ENSG00000154096 Thy-1 cell surface antigen 11 119417378-119424985 CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA003733, CAB068243, CAB068244 Supported Approved Nucleus
Plasma membrane Renal cancer:2.40e-6 (unfavourable), Glioma:9.64e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 422.9;smooth muscle: 428.6 gallbladder: 161.7 FXYD1 PLM ENSG00000266964 FXYD domain containing ion transport regulator 1 19 35138808-35143109 Predicted membrane proteins Evidence at protein level HPA026873 Approved Nucleus
Nucleoli
Cytosol Renal cancer:7.59e-8 (unfavourable), Glioma:9.67e-4 (unfavourable) Tissue enhanced Expressed in all skeletal muscle: 469.2 SNRNP40 HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57 ENSG00000060688 Small nuclear ribonucleoprotein 40kDa (U5) 1 31259568-31296782 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA026527, HPA027345 Supported Supported Nuclear speckles Liver cancer:4.73e-6 (unfavourable), Glioma:9.74e-4 (favourable) Expressed in all Expressed in all lymph node: 41.5 CPQ LDP, PGCP ENSG00000104324 Carboxypeptidase Q 8 96645227-97149654 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA023235, HPA024490 Supported Approved Golgi apparatus
Vesicles Renal cancer:5.40e-5 (favourable), Glioma:9.75e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 380.7 C11orf24 DM4E3 ENSG00000171067 Chromosome 11 open reading frame 24 11 68261335-68272001 Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA012748 Uncertain Uncertain Nucleoplasm
Vesicles Renal cancer:1.60e-9 (unfavourable), Lung cancer:6.05e-4 (unfavourable), Glioma:9.83e-4 (unfavourable) Expressed in all Expressed in all small intestine: 67.2 SAA2-SAA4 ENSG00000255071 SAA2-SAA4 readthrough 11 18231423-18248635 Predicted membrane proteins Evidence at transcript level HPA060139 Uncertain Renal cancer:2.92e-8 (unfavourable), Breast cancer:4.56e-4 (favourable), Glioma:9.87e-4 (unfavourable) Tissue enriched Tissue enhanced adipose tissue: 27.8;cervix, uterine: 22.5;liver: 15.0 breast: 5.4 CUX1 CASP, CDP, CDP/Cut, CDP/Cux, CDP1, Clox, CUT, CUTL1, CUX, Cux/CDP, GOLIM6 ENSG00000257923 Cut-like homeobox 1 7 101815904-102283957 Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA003277, HPA003317 Approved Supported Nucleoplasm
Golgi apparatus Renal cancer:5.72e-7 (favourable), Glioma:9.90e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 82.3 ACADS ACAD3, SCAD ENSG00000122971 Acyl-CoA dehydrogenase, C-2 to C-3 short chain 12 120725735-120740008 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA004799, CAB019284, HPA022271 Supported Supported Nucleoplasm
Mitochondria Renal cancer:3.33e-6 (favourable), Urothelial cancer:6.34e-5 (favourable), Liver cancer:2.43e-4 (favourable), Endometrial cancer:5.05e-4 (favourable), Glioma:9.94e-4 (unfavourable) Expressed in all Expressed in all duodenum: 83.5 TTC30A FLJ13946, IFT70A ENSG00000197557 Tetratricopeptide repeat domain 30A 2 177612992-177618966 Predicted intracellular proteins Evidence at protein level HPA051714, HPA052100, HPA052487 Supported Approved Nucleus
Centrosome Glioma:9.98e-4 (unfavourable) Expressed in all Mixed testis: 17.2