Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ADRBK1 BARK1, GRK2 ENSG00000173020 Adrenergic, beta, receptor kinase 1 11 67266410-67286556 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB005021, CAB037248, HPA048330 Approved Approved Vesicles Renal cancer:1.25e-4 (unfavourable) Expressed in all Expressed in all spleen: 129.5 ADRBK2 BARK2, GRK3 ENSG00000100077 Adrenergic, beta, receptor kinase 2 22 25564849-25729294 Enzymes, Predicted intracellular proteins Evidence at protein level HPA000804 Uncertain Approved Nucleus
Plasma membrane Urothelial cancer:1.29e-4 (favourable) Expressed in all Mixed adipose tissue: 32.7 AKT1 AKT, PKB, PRKBA, RAC ENSG00000142208 V-akt murine thymoma viral oncogene homolog 1 14 104769349-104795751 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA002891, CAB003765 Supported Supported Nucleus
Microtubules Renal cancer:2.12e-4 (favourable), Ovarian cancer:4.83e-4 (favourable) Expressed in all Expressed in all lung: 104.6 AKT2 ENSG00000105221 V-akt murine thymoma viral oncogene homolog 2 19 40230317-40285536 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB004204, HPA064521 Uncertain Supported Nucleus
Vesicles
Cytosol Endometrial cancer:1.05e-6 (unfavourable), Prostate cancer:4.74e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 169.5 AKT3 PKBG, PRKBG, RAC-gamma ENSG00000117020 V-akt murine thymoma viral oncogene homolog 3 1 243488233-243851079 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB013090, HPA026441 Approved Supported Cytosol Urothelial cancer:9.27e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 51.7 CDC42BPA FLJ23347, KIAA0451, MRCK, MRCKA, PK428 ENSG00000143776 CDC42 binding protein kinase alpha (DMPK-like) 1 226989865-227318474 Enzymes, Predicted intracellular proteins Evidence at protein level HPA071252 Approved Intermediate filaments Expressed in all Expressed in all testis: 45.0 CDC42BPB KIAA1124, MRCKB ENSG00000198752 CDC42 binding protein kinase beta (DMPK-like) 14 102932379-103057462 Enzymes, Predicted intracellular proteins Evidence at protein level HPA022821 Approved Approved Nuclear speckles
Cytosol Renal cancer:8.67e-10 (favourable), Lung cancer:2.38e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 75.3 CDC42BPG DMPK2, HSMDPKIN, kappa-200, MRCKgamma ENSG00000171219 CDC42 binding protein kinase gamma (DMPK-like) 11 64823387-64844569 Enzymes, Predicted intracellular proteins Evidence at protein level HPA027382, HPA061836 Approved Supported Cytosol Renal cancer:5.99e-13 (favourable) Mixed Tissue enhanced skin: 35.7 parathyroid gland: 14.3 CIT CRIK, KIAA0949, STK21 ENSG00000122966 Citron rho-interacting serine/threonine kinase 12 119685790-119877291 Enzymes, Predicted intracellular proteins Evidence at protein level HPA019082, HPA048812, HPA075506 Uncertain Approved Cytosol Mixed Mixed cerebral cortex: 10.4 DMPK DM, DM1, DM1PK, DMK, MDPK, MT-PK ENSG00000104936 Dystrophia myotonica-protein kinase 19 45769717-45782552 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA007164, HPA008905 Supported Approved Vesicles
Cytosol Pancreatic cancer:9.39e-5 (favourable) Expressed in all Expressed in all smooth muscle: 96.5 GRK1 GPRK1, RHOK, RK ENSG00000185974 G protein-coupled receptor kinase 1 13 113667155-113737735 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA035200, HPA059376 Supported Tissue enhanced Not detected thyroid gland: 0.8 GRK4 GPRK2L, GPRK4 ENSG00000125388 G protein-coupled receptor kinase 4 4 2963608-3040747 Enzymes, Predicted intracellular proteins Evidence at protein level HPA028737, HPA057023 Approved Supported Vesicles Expressed in all Tissue enriched 9 testis: 74.5 cerebral cortex: 8.2 GRK5 GPRK5 ENSG00000198873 G protein-coupled receptor kinase 5 10 119207589-119459742 Enzymes, Predicted intracellular proteins Evidence at protein level CAB025579, HPA046838 Approved Approved Nuclear membrane
Nuclear speckles
Plasma membrane Renal cancer:2.38e-7 (unfavourable) Expressed in all Expressed in all parathyroid gland: 77.1 GRK6 GPRK6 ENSG00000198055 G protein-coupled receptor kinase 6 5 177403204-177442901 Enzymes, Predicted intracellular proteins Evidence at protein level HPA015327, HPA018903 Approved Approved Mitochondria Liver cancer:5.66e-6 (unfavourable), Pancreatic cancer:1.22e-4 (favourable) Expressed in all Expressed in all bone marrow: 87.7 LATS1 WARTS ENSG00000131023 Large tumor suppressor kinase 1 6 149658153-149718256 Enzymes, Predicted intracellular proteins Evidence at protein level HPA031804 Approved Uncertain Nucleoplasm
Vesicles Expressed in all Expressed in all parathyroid gland: 23.2 LATS2 ENSG00000150457 Large tumor suppressor kinase 2 13 20973032-21061547 Enzymes, Predicted intracellular proteins Evidence at protein level HPA039191, HPA049037 Approved Supported Microtubule organizing center
Cytosol Cervical cancer:3.26e-4 (unfavourable) Expressed in all Expressed in all testis: 25.7 MAST1 KIAA0973, SAST ENSG00000105613 Microtubule associated serine/threonine kinase 1 19 12833951-12874951 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA028181 Approved Vesicles Tissue enhanced Tissue enriched 12 cerebral cortex: 35.3 testis: 3.0 MAST2 KIAA0807, MAST205 ENSG00000086015 Microtubule associated serine/threonine kinase 2 1 45786987-46036124 Cancer-related genes, Enzymes, Predicted membrane proteins Evidence at protein level HPA039722, HPA040155 Approved Approved Cytosol Renal cancer:6.85e-13 (unfavourable), Liver cancer:4.31e-8 (unfavourable) Expressed in all Expressed in all testis: 78.5 MAST3 KIAA0561 ENSG00000099308 Microtubule associated serine/threonine kinase 3 19 18097793-18151692 Enzymes, Predicted intracellular proteins Evidence at protein level HPA035061, HPA035062 Uncertain Approved Nuclear speckles Head and neck cancer:2.97e-4 (favourable), Pancreatic cancer:7.01e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 51.6 MAST4 KIAA0303 ENSG00000069020 Microtubule associated serine/threonine kinase family member 4 5 66596361-67169595 Enzymes, Predicted intracellular proteins Evidence at protein level HPA000544 Approved Approved Nucleoplasm
Cytosol Head and neck cancer:5.18e-5 (favourable) Expressed in all Mixed parathyroid gland: 47.3 MASTL FLJ14813, Gwl, THC2 ENSG00000120539 Microtubule associated serine/threonine kinase-like 10 27154824-27186924 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA027175, HPA054273 Approved Validated Nucleoplasm Renal cancer:1.71e-6 (unfavourable), Liver cancer:2.52e-6 (unfavourable), Pancreatic cancer:4.81e-5 (unfavourable) Expressed in all Mixed testis: 12.6 PDPK1 PDK1 ENSG00000140992 3-phosphoinositide dependent protein kinase 1 16 2537964-2603188 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004272, HPA035199, HPA068961 Supported Approved Vesicles Renal cancer:1.29e-14 (favourable) Expressed in all Expressed in all parathyroid gland: 51.3 PKN1 DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1 ENSG00000123143 Protein kinase N1 19 14433053-14471867 Enzymes, Predicted intracellular proteins Evidence at protein level HPA003982, CAB010278 Approved Supported Nucleus
Nuclear bodies
Cytosol Expressed in all Expressed in all spleen: 87.5 PKN2 Pak-2, PRK2, PRKCL2, STK7 ENSG00000065243 Protein kinase N2 1 88684222-88836255 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA034861 Uncertain Colorectal cancer:5.67e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 48.2 PKN3 PKNbeta, UTDP4-1 ENSG00000160447 Protein kinase N3 9 128702523-128720918 Enzymes, Predicted intracellular proteins Evidence at protein level HPA045390, HPA058305 Uncertain Approved Vesicles Expressed in all Mixed adipose tissue: 7.6 PRKACA PKACa ENSG00000072062 Protein kinase, cAMP-dependent, catalytic, alpha 19 14091688-14118084 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB010361, HPA071185 Approved Approved Cytosol Cervical cancer:6.28e-6 (favourable), Endometrial cancer:6.26e-5 (unfavourable), Pancreatic cancer:6.47e-4 (favourable) Expressed in all Expressed in all heart muscle: 203.1 PRKACB PKACb ENSG00000142875 Protein kinase, cAMP-dependent, catalytic, beta 1 84078062-84238498 Enzymes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB010363, HPA029754, HPA071185 Approved Approved Cytosol Renal cancer:1.89e-6 (favourable), Liver cancer:9.49e-4 (unfavourable) Expressed in all Tissue enriched 5 cerebral cortex: 317.2 adrenal gland: 63.4 PRKACG PKACg ENSG00000165059 Protein kinase, cAMP-dependent, catalytic, gamma 9 69012505-69014113 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB004530, HPA071185 Supported Approved Cytosol Not detected Tissue enriched 297 testis: 29.6 all non-specific tissues: 0.0 PRKCA PKCA ENSG00000154229 Protein kinase C, alpha 17 66302636-66810743 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB003844, HPA006563, HPA006564, CAB016290 Approved Validated Plasma membrane
Cytosol Expressed in all Mixed cerebral cortex: 45.1 PRKCB PKCB, PRKCB1, PRKCB2 ENSG00000166501 Protein kinase C, beta 16 23836001-24220611 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB003843, HPA048321, HPA054203 Approved Supported Nucleoplasm
Cytosol Mixed Tissue enhanced cerebral cortex: 125.8 spleen: 65.5 PRKCD ENSG00000163932 Protein kinase C, delta 3 53156009-53192717 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA001863, HPA001890, CAB010469, CAB013225 Supported Validated Endoplasmic reticulum
Golgi apparatus
Cytosol Liver cancer:2.24e-4 (unfavourable), Lung cancer:9.01e-4 (favourable) Expressed in all Mixed adrenal gland: 70.7 PRKCE ENSG00000171132 Protein kinase C, epsilon 2 45651345-46187990 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level CAB001948, HPA044496, HPA054252 Supported Approved Vesicles Renal cancer:2.63e-7 (favourable), Endometrial cancer:2.42e-4 (unfavourable), Lung cancer:9.62e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 48.5 parathyroid gland: 20.3 PRKCG MGC57564, PKCC, PKCG, SCA14 ENSG00000126583 Protein kinase C, gamma 19 53879190-53907652 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB013051, HPA047870, HPA054560 Supported Mixed Tissue enriched 9 cerebral cortex: 41.1 testis: 4.7 PRKCH PKC-L, PKCL, PRKCL ENSG00000027075 Protein kinase C, eta 14 61187559-61550976 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA026294, HPA053709 Approved Approved Plasma membrane
Cytosol Head and neck cancer:8.55e-6 (favourable) Expressed in all Expressed in all lymph node: 62.3 PRKCI DXS1179E, PKCI ENSG00000163558 Protein kinase C, iota 3 170222365-170305981 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA026574, HPA038635 Approved Validated Microtubules
Cytokinetic bridge
Cytosol Endometrial cancer:3.93e-6 (unfavourable), Pancreatic cancer:1.22e-4 (unfavourable), Liver cancer:3.02e-4 (unfavourable), Renal cancer:3.10e-4 (favourable) Expressed in all Expressed in all thyroid gland: 39.6 PRKCQ ENSG00000065675 Protein kinase C, theta 10 6427143-6580301 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA065279, HPA073098 Supported Microtubule organizing center Thyroid cancer:5.27e-4 (unfavourable) Mixed Tissue enhanced skeletal muscle: 43.0 thyroid gland: 24.8 PRKCZ PKC2 ENSG00000067606 Protein kinase C, zeta 1 2050470-2185395 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA021851 Supported Approved Plasma membrane
Cytosol Renal cancer:1.64e-9 (favourable) Expressed in all Tissue enhanced cerebral cortex: 100.0 placenta: 59.9 PRKG1 PGK, PKG, PRKG1B, PRKGR1B ENSG00000185532 Protein kinase, cGMP-dependent, type I 10 50991358-52298350 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA007699, CAB009629 Approved Approved Vesicles
Cytosol Mixed Mixed smooth muscle: 24.5 PRKG2 cGKII, PRKGR2 ENSG00000138669 Protein kinase, cGMP-dependent, type II 4 81087370-81215117 Enzymes, Predicted intracellular proteins Evidence at protein level HPA007386, CAB018739 Approved Tissue enhanced Tissue enhanced prostate: 14.7;small intestine: 14.7 duodenum: 10.0 PRKX PKX1 ENSG00000183943 Protein kinase, X-linked X 3604370-3713608 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA015324 Supported Supported Nucleus Expressed in all Tissue enhanced thyroid gland: 57.8 fallopian tube: 31.6 ROCK1 p160ROCK ENSG00000067900 Rho-associated, coiled-coil containing protein kinase 1 18 20946906-21111851 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004562, HPA007567, HPA045639 Approved Pancreatic cancer:9.93e-4 (unfavourable) Expressed in all Mixed bone marrow: 12.4 ROCK2 ENSG00000134318 Rho-associated, coiled-coil containing protein kinase 2 2 11179761-11348330 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA007459, CAB008666, HPA044109 Approved Supported Cytosol Renal cancer:1.57e-5 (unfavourable) Expressed in all Expressed in all adipose tissue: 40.7 RPS6KA1 HU-1, p90Rsk, RSK, RSK1 ENSG00000117676 Ribosomal protein S6 kinase, 90kDa, polypeptide 1 1 26529761-26575030 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB003852, HPA007981 Approved Supported Nucleus
Cytosol Endometrial cancer:7.20e-7 (favourable), Renal cancer:1.84e-4 (favourable), Stomach cancer:4.58e-4 (favourable), Urothelial cancer:8.33e-4 (favourable) Expressed in all Mixed small intestine: 39.7 RPS6KA2 HU-2, RSK, RSK3 ENSG00000071242 Ribosomal protein S6 kinase, 90kDa, polypeptide 2 6 166409364-166906451 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB026243, HPA045061, HPA054237, CAB069428 Approved Supported Nucleoplasm Renal cancer:2.86e-5 (favourable), Ovarian cancer:8.63e-5 (unfavourable) Expressed in all Expressed in all parathyroid gland: 73.0 RPS6KA3 CLS, HU-3, MRX19, RSK, RSK2 ENSG00000177189 Ribosomal protein S6 kinase, 90kDa, polypeptide 3 X 20149911-20267100 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA003221, CAB003853, CAB013520 Approved Approved Nucleus
Nucleoli
Cytosol Expressed in all Expressed in all parathyroid gland: 91.0 RPS6KA4 MSK2, RSK-B ENSG00000162302 Ribosomal protein S6 kinase, 90kDa, polypeptide 4 11 64359148-64372215 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB008649, HPA023225 Approved Supported Nucleus
Cytosol Liver cancer:8.17e-4 (unfavourable), Lung cancer:9.27e-4 (unfavourable) Expressed in all Expressed in all spleen: 23.6 RPS6KA5 MSK1, RLPK ENSG00000100784 Ribosomal protein S6 kinase, 90kDa, polypeptide 5 14 90847862-91060636 Enzymes, Predicted intracellular proteins Evidence at protein level HPA001274, HPA001780, CAB025458 Approved Validated Nucleoplasm Mixed Mixed breast: 13.0 RPS6KA6 RSK4 ENSG00000072133 Ribosomal protein S6 kinase, 90kDa, polypeptide 6 X 84058346-84187907 Enzymes, Predicted intracellular proteins Evidence at protein level HPA002852, HPA003904 Uncertain Supported Nucleus
Nucleoli
Mitochondria Mixed Tissue enhanced parathyroid gland: 18.6;thyroid gland: 21.8 kidney: 8.8 RPS6KB1 p70(S6K)-alpha, PS6K, S6K1, STK14A ENSG00000108443 Ribosomal protein S6 kinase, 70kDa, polypeptide 1 17 59893046-59950564 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB003838, CAB018346, HPA039442 Approved Supported Nucleoplasm Renal cancer:5.09e-7 (unfavourable) Expressed in all Expressed in all parathyroid gland: 28.0 RPS6KB2 KLS, P70-BETA, p70S6Kb, STK14B ENSG00000175634 Ribosomal protein S6 kinase, 70kDa, polypeptide 2 11 67428460-67435408 Enzymes, Predicted intracellular proteins Evidence at protein level HPA010010, CAB019404 Approved Supported Cytosol Renal cancer:2.03e-7 (unfavourable) Expressed in all Expressed in all skin: 65.4 SGK1 SGK ENSG00000118515 Serum/glucocorticoid regulated kinase 1 6 134169246-134318112 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level CAB022085, CAB025148, HPA051251 Approved Supported Nuclear speckles
Cytosol Cervical cancer:5.26e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 778.6 SGK2 ENSG00000101049 Serum/glucocorticoid regulated kinase 2 20 43558968-43588237 Enzymes, Predicted intracellular proteins Evidence at protein level HPA008859, HPA011387 Uncertain Supported Nucleoplasm Urothelial cancer:5.65e-4 (favourable) Group enriched Mixed kidney: 42.9 SGK3 SGK2, SGKL ENSG00000104205 Serum/glucocorticoid regulated kinase family, member 3 8 66712418-66862022 Enzymes, Predicted intracellular proteins Evidence at protein level HPA027146 Supported Breast cancer:5.52e-6 (favourable), Cervical cancer:8.28e-4 (favourable), Pancreatic cancer:9.65e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 47.7 STK38 NDR ENSG00000112079 Serine/threonine kinase 38 6 36493892-36547470 Enzymes, Predicted intracellular proteins Evidence at protein level CAB004673, HPA038623, HPA051324 Uncertain Approved Cytosol Melanoma:9.44e-5 (unfavourable) Expressed in all Expressed in all rectum: 40.9 STK38L KIAA0965, NDR2 ENSG00000211455 Serine/threonine kinase 38 like 12 27243968-27325959 Enzymes, Predicted intracellular proteins Evidence at protein level HPA038623, HPA051324 Approved Approved Cytosol Pancreatic cancer:5.82e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 64.3