Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ABI1 ABI-1, E3B1, SSH3BP1 ENSG00000136754 Abl-interactor 1 10 26746593-26861087 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB008375, HPA029973, HPA068407 Approved Supported Plasma membrane
Cell Junctions Expressed in all Expressed in all cerebral cortex: 87.6 ABL1 ABL, c-ABL, JTK7, p150 ENSG00000097007 ABL proto-oncogene 1, non-receptor tyrosine kinase 9 130713946-130887675 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB002686, HPA027251, HPA027280, HPA028409 Supported Validated Nucleoplasm
Nuclear bodies Expressed in all Expressed in all parathyroid gland: 82.2 ABL2 ABLL, ARG ENSG00000143322 ABL proto-oncogene 2, non-receptor tyrosine kinase 1 179099327-179229684 Cancer-related genes, Enzymes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA001866, CAB017106 Uncertain Supported Nucleoplasm Renal cancer:1.78e-7 (unfavourable), Cervical cancer:3.50e-4 (unfavourable), Urothelial cancer:8.40e-4 (unfavourable) Expressed in all Mixed gallbladder: 20.3 ACKR3 CMKOR1, CXCR7, GPR159, RDC1 ENSG00000144476 Atypical chemokine receptor 3 2 236567787-236582358 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA032003, HPA049718 Approved Supported Vesicles
Plasma membrane Renal cancer:1.76e-6 (unfavourable), Stomach cancer:2.01e-4 (unfavourable), Urothelial cancer:2.93e-4 (unfavourable), Cervical cancer:4.64e-4 (unfavourable) Expressed in all Expressed in all placenta: 175.2 ACSL3 ACS3, FACL3, PRO2194 ENSG00000123983 Acyl-CoA synthetase long-chain family member 3 2 222860934-222944639 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA011315, HPA071021 Uncertain Approved Nucleoli
Lipid droplets Liver cancer:2.75e-4 (unfavourable), Lung cancer:8.78e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 670.1 ACSL6 ACS2, FACL6, KIAA0837, LACS2, LACS5 ENSG00000164398 Acyl-CoA synthetase long-chain family member 6 5 131949973-132012243 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA040470 Uncertain Group enriched Group enriched 6 bone marrow: 18.0;cerebral cortex: 62.1;parathyroid gland: 22.1;seminal vesicle: 28.7;testis: 51.2 adrenal gland: 6.5 ACVR1 ACVR1A, ACVRLK2, ALK2, SKR1 ENSG00000115170 Activin A receptor, type I 2 157736444-157875862 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA007505 Approved Urothelial cancer:5.17e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 73.9 AFF1 AF-4, AF4, MLLT2, PBM1 ENSG00000172493 AF4/FMR2 family, member 1 4 86935002-87141054 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA069947 Approved Nucleoplasm
Mitochondria Expressed in all Expressed in all thyroid gland: 91.1 AFF3 LAF4, MLLT2-like ENSG00000144218 AF4/FMR2 family, member 3 2 99545419-100142739 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA044512, HPA053379 Approved Supported Nucleoplasm
Cytosol Renal cancer:5.64e-4 (unfavourable) Tissue enhanced Mixed prostate: 27.1 AFF4 AF5Q31, MCEF ENSG00000072364 AF4/FMR2 family, member 4 5 132875379-132963634 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA023690, HPA029634 Approved Supported Nucleus
Nucleoli fibrillar center Thyroid cancer:6.44e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 73.0 AKAP9 AKAP350, AKAP450, CG-NAP, HYPERION, KIAA0803, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO ENSG00000127914 A kinase (PRKA) anchor protein 9 7 91940867-92110673 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA008548, CAB012909, HPA026109 Supported Validated Golgi apparatus
Vesicles
Centrosome Renal cancer:2.10e-6 (favourable) Expressed in all Expressed in all parathyroid gland: 37.2 AKT1 AKT, PKB, PRKBA, RAC ENSG00000142208 V-akt murine thymoma viral oncogene homolog 1 14 104769349-104795751 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA002891, CAB003765 Supported Supported Nucleus
Microtubules Renal cancer:2.12e-4 (favourable), Ovarian cancer:4.83e-4 (favourable) Expressed in all Expressed in all lung: 104.6 AKT2 ENSG00000105221 V-akt murine thymoma viral oncogene homolog 2 19 40230317-40285536 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB004204, HPA064521 Uncertain Supported Nucleus
Vesicles
Cytosol Endometrial cancer:1.05e-6 (unfavourable), Prostate cancer:4.74e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 169.5 ALDH2 ENSG00000111275 Aldehyde dehydrogenase 2 family (mitochondrial) 12 111766887-111817529 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA051065 Approved Liver cancer:3.95e-7 (favourable), Renal cancer:5.24e-6 (favourable), Endometrial cancer:2.63e-4 (favourable), Urothelial cancer:7.71e-4 (unfavourable) Expressed in all Expressed in all liver: 440.7 ALK CD246 ENSG00000171094 Anaplastic lymphoma receptor tyrosine kinase 2 29192774-29921566 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010694 Approved Supported Plasma membrane Group enriched Tissue enhanced cerebral cortex: 3.5;testis: 2.3 adrenal gland: 0.9 AMER1 FAM123B, FLJ39827, RP11-403E24.2, WTX ENSG00000184675 APC membrane recruitment protein 1 X 64185117-64205744 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA065214, HPA065265 Approved Supported Nuclear bodies
Vesicles
Plasma membrane Expressed in all Mixed ovary: 7.7 APC DP2, DP2.5, DP3, PPP1R46 ENSG00000134982 Adenomatous polyposis coli 5 112707498-112846239 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA013349, CAB025994 Approved Expressed in all Tissue enhanced cerebral cortex: 60.3 parathyroid gland: 19.5 ARHGAP26 GRAF, KIAA0621, OPHN1L, OPHN1L1 ENSG00000145819 Rho GTPase activating protein 26 5 142770384-143229011 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA035106, HPA035107 Approved Approved Cytosol Urothelial cancer:2.88e-6 (favourable), Endometrial cancer:5.93e-6 (favourable), Cervical cancer:1.36e-4 (favourable), Breast cancer:2.05e-4 (favourable), Colorectal cancer:6.95e-4 (favourable) Expressed in all Mixed cerebral cortex: 30.9 ARHGEF12 KIAA0382, LARG ENSG00000196914 Rho guanine nucleotide exchange factor (GEF) 12 11 120336914-120489936 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA018911, CAB025581 Approved Approved Nucleoplasm
Plasma membrane
Cytosol Renal cancer:5.43e-6 (favourable) Expressed in all Expressed in all parathyroid gland: 143.2 ARID1A B120, BAF250, BAF250a, C10rf4, C1orf4, P270, SMARCF1 ENSG00000117713 AT rich interactive domain 1A (SWI-like) 1 26696033-26782104 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005456, CAB016334 Supported Validated Nucleoplasm Liver cancer:4.18e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 40.4 ARID1B 6A3-5, BAF250b, DAN15, ELD/OSA1, KIAA1235, p250R ENSG00000049618 AT rich interactive domain 1B (SWI1-like) 6 156777374-157210779 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA016511, HPA075291 Approved Supported Nucleoplasm Breast cancer:1.04e-4 (unfavourable), Ovarian cancer:4.16e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 75.6 ARID2 BAF200, DKFZp686G052, FLJ30619, KIAA1557 ENSG00000189079 AT rich interactive domain 2 (ARID, RFX-like) 12 45729665-45908040 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA063044 Supported Nucleoplasm
Plasma membrane Head and neck cancer:5.75e-4 (favourable) Expressed in all Expressed in all testis: 47.3 ARNT bHLHe2, HIF-1beta ENSG00000143437 Aryl hydrocarbon receptor nuclear translocator 1 150809705-150876768 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001759, CAB004318 Supported Supported Nucleus
Nuclear bodies Expressed in all Expressed in all ovary: 46.6 ASPSCR1 ASPL, ASPS, UBXD9, UBXN9 ENSG00000169696 Alveolar soft part sarcoma chromosome region, candidate 1 17 81976807-82017406 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA026749 Approved Supported Nucleoplasm
Vesicles
Plasma membrane Renal cancer:1.26e-4 (unfavourable), Pancreatic cancer:2.67e-4 (favourable), Head and neck cancer:8.55e-4 (favourable) Expressed in all Expressed in all testis: 21.3 ASXL1 KIAA0978 ENSG00000171456 Additional sex combs like transcriptional regulator 1 20 32358344-32439319 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA064156 Approved Nucleus
Nucleoli Endometrial cancer:2.86e-4 (unfavourable), Head and neck cancer:9.16e-4 (favourable) Expressed in all Expressed in all testis: 68.2 ATF1 TREB36 ENSG00000123268 Activating transcription factor 1 12 50763710-50821122 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB016222, HPA055069, HPA055406 Supported Validated Nucleoplasm Liver cancer:1.53e-5 (unfavourable) Expressed in all Expressed in all thyroid gland: 39.5 ATIC AICARFT, IMPCHASE, PURH ENSG00000138363 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 2 215311817-215349773 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013462, HPA021012 Supported Validated Plasma membrane
Cytosol Liver cancer:1.99e-7 (unfavourable), Renal cancer:8.77e-4 (unfavourable) Expressed in all Expressed in all placenta,rectum: 44.5 ATM ATA, ATC, ATD, ATDC, TEL1, TELO1 ENSG00000149311 ATM serine/threonine kinase 11 108222484-108369102 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB000102, HPA067142 Supported Supported Nucleoplasm Expressed in all Expressed in all lymph node: 41.6 ATP1A1 ENSG00000163399 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1 116372668-116410261 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB018702, CAB069993 Supported Renal cancer:8.98e-8 (favourable), Liver cancer:1.42e-4 (unfavourable), Urothelial cancer:4.01e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 2441.5 ATP2B3 CFAP39, CLA2, PMCA3, SCAX1 ENSG00000067842 ATPase, Ca++ transporting, plasma membrane 3 X 153517676-153582939 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA001583 Supported Uncertain Golgi apparatus
Plasma membrane Not detected Group enriched 8 adrenal gland: 12.2;cerebral cortex: 19.1 fallopian tube: 2.0 ATR FRP1, MEC1, SCKL, SCKL1 ENSG00000175054 ATR serine/threonine kinase 3 142449235-142578826 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA054320 Supported Nucleoplasm
Golgi apparatus Pancreatic cancer:1.23e-5 (unfavourable), Liver cancer:8.39e-5 (unfavourable) Expressed in all Mixed parathyroid gland: 15.2 ATRX JMS, MRX52, RAD54, XH2, XNP ENSG00000085224 Alpha thalassemia/mental retardation syndrome X-linked X 77504878-77786269 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001906, CAB009372, HPA064684, CAB068176 Supported Supported Nuclear bodies Expressed in all Expressed in all parathyroid gland: 53.5 AXIN1 PPP1R49 ENSG00000103126 Axin 1 16 287440-352673 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB012987 Approved Supported Nucleoli
Vesicles Liver cancer:3.38e-5 (unfavourable) Expressed in all Expressed in all spleen: 15.8 AXIN2 DKFZp781B0869, MGC126582 ENSG00000168646 Axin 2 17 65528563-65561647 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB012283, CAB017783 Approved Uncertain Nucleus
Plasma membrane
Cytosol Pancreatic cancer:6.58e-4 (favourable) Expressed in all Mixed endometrium: 31.0 BAP1 hucep-6, KIAA0272, UCHL2 ENSG00000163930 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 3 52401013-52410350 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004322, HPA028814, HPA028815, HPA055560 Approved Validated Nucleoplasm
Cytosol Renal cancer:3.29e-7 (favourable) Expressed in all Expressed in all testis: 118.1 BCL10 c-E10, CARMEN, CIPER, CLAP, mE10 ENSG00000142867 B-cell CLL/lymphoma 10 1 85266248-85277090 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB001944, HPA017925 Approved Approved Nucleoplasm Liver cancer:7.21e-7 (unfavourable), Colorectal cancer:2.51e-4 (favourable) Expressed in all Expressed in all gallbladder: 30.5 BCL11A BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856 ENSG00000119866 B-cell CLL/lymphoma 11A (zinc finger protein) 2 60451167-60553567 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB014891, HPA029003 Approved Validated Nucleoplasm
Nuclear bodies Mixed Tissue enhanced skin: 41.0 tonsil: 31.8 BCL11B CTIP-2, CTIP2, hRIT1-alpha, ZNF856B ENSG00000127152 B-cell CLL/lymphoma 11B (zinc finger protein) 14 99169287-99271524 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA049117 Supported Supported Approved Nucleus
Nucleoli fibrillar center Urothelial cancer:7.48e-4 (favourable) Mixed Tissue enhanced lymph node: 12.4;skin: 18.8 tonsil: 7.7 BCL2 Bcl-2, PPP1R50 ENSG00000171791 B-cell CLL/lymphoma 2 18 63123346-63320128 Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB000003, HPA055295 Supported Supported Nucleoplasm
Nuclear membrane Renal cancer:1.29e-8 (favourable), Cervical cancer:5.13e-5 (favourable), Thyroid cancer:2.47e-4 (unfavourable) Expressed in all Tissue enhanced thyroid gland: 69.2 parathyroid gland: 34.6 BCL3 BCL4, D19S37 ENSG00000069399 B-cell CLL/lymphoma 3 19 44747705-44760044 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB002051, HPA047514 Approved Supported Nucleoplasm
Vesicles
Midbody Renal cancer:3.13e-14 (unfavourable), Melanoma:3.74e-4 (favourable), Glioma:5.58e-4 (unfavourable), Breast cancer:9.67e-4 (favourable) Expressed in all Expressed in all appendix: 30.9 BCL6 BCL5, BCL6A, LAZ3, ZBTB27, ZNF51 ENSG00000113916 B-cell CLL/lymphoma 6 3 187721377-187745727 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000307, HPA004899, HPA050645 Supported Validated Nucleoplasm
Golgi apparatus Renal cancer:1.27e-9 (unfavourable) Expressed in all Expressed in all adipose tissue: 112.8 BCL7A BCL7 ENSG00000110987 B-cell CLL/lymphoma 7A 12 122019422-122062044 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA019762 Approved Approved Nucleoplasm
Vesicles Renal cancer:1.54e-6 (favourable), Liver cancer:2.04e-4 (unfavourable), Colorectal cancer:6.81e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 13.8 BCL9 ENSG00000116128 B-cell CLL/lymphoma 9 1 147541412-147626216 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA020274 Approved Approved Nucleoplasm
Nuclear bodies Liver cancer:6.74e-4 (unfavourable) Expressed in all Mixed fallopian tube: 26.3 BCOR FLJ20285, KIAA1575 ENSG00000183337 BCL6 corepressor X 40049815-40177329 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA056308, HPA066234 Validated Nucleus Liver cancer:1.30e-5 (unfavourable) Expressed in all Expressed in all parathyroid gland: 33.3 BCR ALL, BCR1, CML, D22S11, D22S662, PHL ENSG00000186716 Breakpoint cluster region 22 23179704-23318037 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level CAB010421, CAB018545, HPA038337 Approved Approved Nucleoplasm
Cytosol Renal cancer:9.15e-10 (favourable) Expressed in all Expressed in all cerebral cortex: 48.5 BIRC3 API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49 ENSG00000023445 Baculoviral IAP repeat containing 3 11 102317450-102339403 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002317 Supported Approved Supported Nucleoplasm
Cytosol Renal cancer:6.66e-6 (unfavourable), Pancreatic cancer:3.03e-4 (unfavourable), Breast cancer:3.60e-4 (favourable), Colorectal cancer:9.35e-4 (favourable) Expressed in all Tissue enhanced lymph node: 139.7 appendix: 121.3 BLM BS, RECQ2, RECQL3 ENSG00000197299 Bloom syndrome, RecQ helicase-like 15 90717327-90816165 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA005689 Approved Supported Nucleus
Cytosol Mixed Mixed lymph node: 3.8 BMPR1A ACVRLK3, ALK3, CD292 ENSG00000107779 Bone morphogenetic protein receptor, type IA 10 86756650-86932838 Cancer-related genes, CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB019398 Approved Approved Cytosol Liver cancer:8.93e-4 (unfavourable), Glioma:9.38e-4 (favourable) Expressed in all Mixed thyroid gland: 33.8 BRAF BRAF1 ENSG00000157764 B-Raf proto-oncogene, serine/threonine kinase 7 140719327-140924764 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level HPA001328, CAB004552, HPA071048 Approved Approved Vesicles
Cytosol Expressed in all Expressed in all testis: 41.6 BRCA1 BRCC1, FANCS, PPP1R53, RNF53 ENSG00000012048 Breast cancer 1, early onset 17 43044295-43170245 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB001946, HPA034966 Approved Expressed in all Mixed testis: 23.9 BRCA2 BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, XRCC11 ENSG00000139618 Breast cancer 2, early onset 13 32315474-32400266 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA026815 Uncertain Approved Nucleoplasm
Cytosol Mixed Tissue enhanced testis: 5.1 bone marrow: 4.1 BRD3 KIAA0043, ORFX, RING3L ENSG00000169925 Bromodomain containing 3 9 134030305-134068535 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA051830 Approved Approved Nuclear bodies Renal cancer:2.71e-7 (favourable) Expressed in all Expressed in all cerebral cortex: 21.4 BRD4 CAP, HUNK1, HUNKI, MCAP ENSG00000141867 Bromodomain containing 4 19 15235519-15332545 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA015055, HPA061646, CAB068177, CAB068178 Supported Validated Nucleoplasm Expressed in all Expressed in all placenta: 41.6 BRIP1 BACH1, FANCJ, OF ENSG00000136492 BRCA1 interacting protein C-terminal helicase 1 17 61681266-61863521 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA005474 Approved Supported Nucleus
Nuclear membrane Colorectal cancer:3.45e-5 (favourable), Head and neck cancer:3.62e-4 (favourable) Mixed Tissue enhanced testis: 14.4 bone marrow: 5.0 BTG1 ENSG00000133639 B-cell translocation gene 1, anti-proliferative 12 92140278-92145897 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA005972 Approved Nucleoplasm
Cytosol Renal cancer:1.95e-7 (unfavourable), Breast cancer:4.36e-5 (favourable) Expressed in all Expressed in all bone marrow: 261.6 BUB1B Bub1A, BUBR1, MAD3L, SSK1 ENSG00000156970 BUB1 mitotic checkpoint serine/threonine kinase B 15 40161023-40221136 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA008419 Supported Cytosol Liver cancer:7.43e-6 (unfavourable), Pancreatic cancer:1.79e-4 (unfavourable), Lung cancer:3.56e-4 (unfavourable) Expressed in all Tissue enhanced testis: 40.2 lymph node: 15.1 C15orf65 FLJ27352 ENSG00000261652 Chromosome 15 open reading frame 65 15 55408548-55418764 Cancer-related genes, Predicted intracellular proteins Evidence at transcript level HPA067189 Approved Approved Nucleus
Cytosol Endometrial cancer:3.18e-7 (favourable) Expressed in all Mixed testis: 16.8 C2orf44 FLJ21945 ENSG00000163026 Chromosome 2 open reading frame 44 2 24029340-24049575 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA041054 Approved Approved Nucleoli
Cytosol Liver cancer:5.14e-8 (unfavourable), Endometrial cancer:6.53e-4 (unfavourable) Expressed in all Mixed testis: 9.2 CACNA1D CACH3, CACN4, CACNL1A2, Cav1.3, CCHL1A2 ENSG00000157388 Calcium channel, voltage-dependent, L type, alpha 1D subunit 3 53494656-53813733 Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA020215 Uncertain Approved Nuclear membrane Renal cancer:8.34e-8 (favourable) Mixed Mixed fallopian tube: 13.7 CALR cC1qR, CRT, FLJ26680, RO, SSA ENSG00000179218 Calreticulin 19 12938578-12944489 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB001513, HPA002242, CAB019952 Supported Renal cancer:1.11e-16 (unfavourable), Ovarian cancer:1.10e-4 (favourable) Expressed in all Expressed in all thyroid gland: 1647.1 CAMTA1 KIAA0833 ENSG00000171735 Calmodulin binding transcription activator 1 1 6785324-7769706 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA036342, HPA036343 Approved Supported Nucleoli
Cytosol Ovarian cancer:4.10e-4 (favourable), Liver cancer:5.25e-4 (unfavourable) Expressed in all Expressed in all epididymis: 98.1 CANT1 SCAN-1, SHAPY ENSG00000171302 Calcium activated nucleotidase 1 17 78991717-79009867 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA019627, HPA019639, HPA022818 Supported Liver cancer:1.41e-4 (unfavourable), Lung cancer:2.90e-4 (unfavourable), Renal cancer:6.21e-4 (unfavourable) Expressed in all Expressed in all prostate: 110.0 CARD11 BIMP3, CARMA1 ENSG00000198286 Caspase recruitment domain family, member 11 7 2906141-3043945 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA052984 Approved Renal cancer:6.68e-8 (unfavourable), Urothelial cancer:1.10e-4 (favourable) Expressed in all Tissue enhanced lymph node: 55.1;spleen: 41.0 appendix: 29.3 CARS CARS1 ENSG00000110619 Cysteinyl-tRNA synthetase 11 3000922-3057613 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA002383, HPA002384, CAB075734, CAB075735, CAB075736, CAB075737 Supported Validated Cytosol Renal cancer:0.00e+0 (unfavourable), Liver cancer:5.16e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 28.2 CASC5 AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Spc7 ENSG00000137812 Cancer susceptibility candidate 5 15 40594020-40664342 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA026624, HPA049647 Supported Validated Nucleoplasm
Nuclear bodies Lung cancer:2.11e-4 (unfavourable) Mixed Tissue enriched 7 testis: 31.6 lymph node: 4.5 CASP8 Casp-8, FLICE, MACH, MCH5 ENSG00000064012 Caspase 8, apoptosis-related cysteine peptidase 2 201233443-201287711 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA001302, CAB002047, HPA005688, HPA006191 Approved Validated Nucleoplasm
Cytosol Renal cancer:1.27e-6 (unfavourable), Ovarian cancer:1.25e-4 (favourable), Liver cancer:3.02e-4 (unfavourable) Expressed in all Expressed in all spleen: 45.6 CBFA2T3 MTG16, MTGR2, ZMYND4 ENSG00000129993 Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 16 88874858-88977204 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA059931, HPA062423, HPA065890 Approved Validated Nucleoplasm Head and neck cancer:3.95e-4 (favourable) Mixed Tissue enhanced spleen: 19.1 lymph node: 10.6 CBFB PEBP2B ENSG00000067955 Core-binding factor, beta subunit 16 67029116-67101058 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA038852 Uncertain Approved Nucleus
Cytosol Renal cancer:2.89e-8 (unfavourable), Liver cancer:2.83e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 95.6 CBL c-Cbl, CBL2, RNF55 ENSG00000110395 Cbl proto-oncogene, E3 ubiquitin protein ligase 11 119206276-119308149 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB004350, HPA027956 Supported Supported Cytosol Expressed in all Mixed testis: 33.1 CBLB Cbl-b, RNF56 ENSG00000114423 Cbl proto-oncogene B, E3 ubiquitin protein ligase 3 105655461-105869552 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA018327, HPA019880 Approved Supported Nucleoplasm
Cytosol Expressed in all Expressed in all lymph node: 28.4 CBLC CBL-3, CBL-SL, RNF57 ENSG00000142273 Cbl proto-oncogene C, E3 ubiquitin protein ligase 19 44777869-44800634 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB008087, HPA035266 Approved Approved Nucleoplasm Renal cancer:3.11e-6 (favourable) Mixed Tissue enhanced duodenum: 53.9;skin: 42.0;small intestine: 44.9 colon: 21.8 CCDC6 D10S170, H4, PTC, TPC, TST1 ENSG00000108091 Coiled-coil domain containing 6 10 59788763-59906656 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA019049, HPA019051 Supported Supported Cytosol Liver cancer:1.11e-4 (unfavourable), Pancreatic cancer:3.95e-4 (unfavourable), Head and neck cancer:5.48e-4 (favourable) Expressed in all Expressed in all smooth muscle: 43.8 CCND1 BCL1, D11S287E, PRAD1, U21B31 ENSG00000110092 Cyclin D1 11 69641087-69654474 Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level CAB000024, HPA027802 Uncertain Supported Nucleoplasm Pancreatic cancer:1.96e-4 (unfavourable), Head and neck cancer:5.51e-4 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 335.1 skin: 140.9 CCND2 ENSG00000118971 Cyclin D2 12 4273772-4305350 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA049138, HPA054196 Approved Supported Nucleoplasm Thyroid cancer:9.76e-5 (favourable), Pancreatic cancer:2.52e-4 (favourable) Expressed in all Mixed epididymis: 55.1 CCND3 ENSG00000112576 Cyclin D3 6 41934933-42050357 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB000116, HPA055107 Approved Supported Plasma membrane
Focal adhesion sites
Cytosol Thyroid cancer:8.08e-6 (favourable) Expressed in all Expressed in all lymph node: 161.4 CCNE1 CCNE ENSG00000105173 Cyclin E1 19 29811898-29824308 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB000308, CAB016682, HPA018169 Approved Validated Nucleoplasm Endometrial cancer:6.35e-6 (unfavourable), Liver cancer:3.89e-5 (unfavourable), Ovarian cancer:2.97e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 44.3 testis: 22.4 CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1 ENSG00000120217 CD274 molecule 9 5450503-5470566 Cancer-related genes, CD markers, Predicted membrane proteins Evidence at protein level CAB030018 Approved Cytosol Colorectal cancer:1.64e-5 (favourable), Breast cancer:8.89e-4 (favourable) Mixed Mixed appendix: 14.4 CD74 DHLAG ENSG00000019582 CD74 molecule, major histocompatibility complex, class II invariant chain 5 150401637-150412929 Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins Evidence at protein level CAB002506, HPA010592 Supported Supported Golgi apparatus Endometrial cancer:6.53e-6 (favourable), Breast cancer:1.06e-4 (favourable) Expressed in all Expressed in all spleen: 6665.5 CD79A IGA, MB-1 ENSG00000105369 CD79a molecule, immunoglobulin-associated alpha 19 41877120-41881372 Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000019 Supported Head and neck cancer:1.18e-5 (favourable), Renal cancer:2.15e-5 (unfavourable), Breast cancer:8.45e-5 (favourable) Mixed Group enriched 6 appendix: 275.4;lymph node: 522.9;spleen: 324.4;tonsil: 440.3 stomach: 62.7 CD79B B29, IGB ENSG00000007312 CD79b molecule, immunoglobulin-associated beta 17 63928740-63932354 Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins Evidence at protein level HPA009178, CAB009751 Approved Uncertain Nucleoplasm
Plasma membrane
Cytosol Head and neck cancer:2.35e-4 (favourable) Expressed in all Group enriched 5 appendix: 94.7;lymph node: 315.6;spleen: 160.3;tonsil: 196.1 bone marrow: 36.2 CDC73 C1orf28, FIHP, HRPT1, HRPT2, parafibromin ENSG00000134371 Cell division cycle 73 1 193122017-193253901 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB016359, HPA030772 Supported Supported Nucleus
Cytosol Expressed in all Expressed in all thyroid gland: 32.0 CDH1 CD324, UVO, uvomorulin ENSG00000039068 Cadherin 1, type 1 16 68737225-68835548 Cancer-related genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000087, HPA004812, CAB028364, CAB072855, CAB072856, CAB072857 Supported Supported Golgi apparatus
Plasma membrane
Cell Junctions Renal cancer:2.06e-4 (favourable) Expressed in all Tissue enhanced parathyroid gland: 467.0 thyroid gland: 264.7 CDH11 CAD11, OB ENSG00000140937 Cadherin 11, type 2, OB-cadherin (osteoblast) 16 64943753-65126112 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB013072 Approved Renal cancer:2.48e-9 (unfavourable) Expressed in all Tissue enhanced ovary: 223.0 placenta: 172.7 CDK12 CRK7, CRKR, CRKRS, KIAA0904 ENSG00000167258 Cyclin-dependent kinase 12 17 39461511-39564907 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA008038 Supported Supported Nucleus Expressed in all Expressed in all testis: 33.8 CDK4 PSK-J3 ENSG00000135446 Cyclin-dependent kinase 4 12 57747727-57756013 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006024, CAB069405 Approved Supported Nucleus
Nuclear membrane
Nucleoli
Cytosol Liver cancer:2.09e-7 (unfavourable), Renal cancer:3.15e-5 (unfavourable) Expressed in all Expressed in all endometrium: 120.2 CDK6 PLSTIRE ENSG00000105810 Cyclin-dependent kinase 6 7 92604921-92836594 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002637, CAB004363 Supported Supported Nucleoplasm
Cytosol Pancreatic cancer:3.86e-6 (unfavourable), Urothelial cancer:2.33e-5 (unfavourable) Expressed in all Mixed parathyroid gland: 33.5 CDKN1B KIP1, P27KIP1 ENSG00000111276 Cyclin-dependent kinase inhibitor 1B (p27, Kip1) 12 12715058-12722371 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB003691, CAB021888, HPA059086 Approved Supported Nucleus
Vesicles Liver cancer:3.25e-4 (unfavourable), Colorectal cancer:5.15e-4 (favourable), Renal cancer:8.39e-4 (unfavourable) Expressed in all Expressed in all ovary: 72.9 CDKN2A ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf ENSG00000147889 Cyclin-dependent kinase inhibitor 2A 9 21967753-21995301 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB000093, CAB000445, CAB018232, HPA047838 Uncertain Validated Nucleoli Endometrial cancer:1.82e-7 (unfavourable), Renal cancer:5.76e-7 (unfavourable), Liver cancer:2.17e-4 (unfavourable), Head and neck cancer:5.19e-4 (favourable) Expressed in all Mixed parathyroid gland: 7.5 CDKN2C INK4C, p18 ENSG00000123080 Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1 50960745-50974633 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB005303, CAB018398, HPA019057, HPA019764 Approved Approved Nucleoplasm
Cytosol Renal cancer:1.70e-10 (unfavourable), Liver cancer:1.58e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 80.3 CDX2 CDX3 ENSG00000165556 Caudal type homeobox 2 13 27962137-27971139 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB002221, HPA045669, HPA049580 Supported Supported Nucleoplasm Tissue enriched Group enriched 6 colon: 31.4;duodenum: 22.9;rectum: 25.3;small intestine: 30.8 appendix: 4.9 CEBPA C/EBP-alpha, CEBP ENSG00000245848 CCAAT/enhancer binding protein (C/EBP), alpha 19 33299934-33302564 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA052734, HPA065037, HPA067937 Approved Approved Nucleoplasm
Vesicles Expressed in all Expressed in all adipose tissue: 107.9 CEP89 CCDC123, FLJ14640 ENSG00000121289 Centrosomal protein 89kDa 19 32875925-32971991 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA039382, HPA040056 Uncertain Supported Plasma membrane
Cytosol Liver cancer:8.78e-5 (unfavourable) Expressed in all Mixed fallopian tube: 14.8 CHCHD7 COX23, MGC2217 ENSG00000170791 Coiled-coil-helix-coiled-coil-helix domain containing 7 8 56211686-56218798 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA050783 Approved Approved Cell Junctions
Aggresome Endometrial cancer:1.39e-6 (unfavourable), Renal cancer:9.47e-5 (favourable) Expressed in all Expressed in all ovary: 61.5 CHEK2 bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53 ENSG00000183765 Checkpoint kinase 2 22 28687743-28742422 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA001878, CAB002030 Approved Supported Nucleoplasm
Golgi apparatus Renal cancer:7.80e-9 (unfavourable) Expressed in all Mixed testis: 13.2 CHIC2 BTL ENSG00000109220 Cysteine-rich hydrophobic domain 2 4 54009789-54064690 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA026782 Uncertain Renal cancer:1.56e-4 (unfavourable) Expressed in all Expressed in all testis: 62.9 CHN1 ARHGAP2, CHN, DURS2, n-chimerin, RhoGAP2 ENSG00000128656 Chimerin 1 2 174799363-175005369 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA036111 Approved Cytosol Renal cancer:5.07e-4 (unfavourable) Expressed in all Group enriched 7 cerebral cortex: 640.9;parathyroid gland: 131.0 placenta: 55.5 CIC KIAA0306 ENSG00000079432 Capicua transcriptional repressor 19 42268537-42295797 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB026388, HPA044341, HPA064725 Approved Supported Nucleoplasm
Vesicles Expressed in all Expressed in all testis: 55.0 CIITA C2TA, MHC2TA, NLRA ENSG00000179583 Class II, major histocompatibility complex, transactivator 16 10877198-10932281 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB016084 Approved Approved Nucleoplasm Expressed in all Mixed spleen: 53.8 CLIP1 CLIP, CLIP-170, CLIP170, CYLN1, RSN ENSG00000130779 CAP-GLY domain containing linker protein 1 12 122271432-122422632 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004399, HPA026678 Approved Supported Microtubule ends
Cytosol Expressed in all Expressed in all parathyroid gland: 156.2 CLP1 hClp1, HEAB ENSG00000172409 Cleavage and polyadenylation factor I subunit 1 11 57648992-57661868 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA057770 Supported Supported Nucleoplasm Expressed in all Expressed in all bone marrow: 17.1 CLTC CLTCL2, Hc ENSG00000141367 Clathrin, heavy chain (Hc) 17 59619689-59696956 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB010389, CAB011571, CAB017155, HPA059143 Approved Validated Endosomes
Lysosomes Urothelial cancer:2.02e-4 (unfavourable), Liver cancer:5.54e-4 (unfavourable), Cervical cancer:7.35e-4 (unfavourable), Colorectal cancer:7.65e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 358.1 CLTCL1 CHC22, CLH22, CLTCL, CLTD ENSG00000070371 Clathrin, heavy chain-like 1 22 19179473-19291716 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA075795 Approved Vesicles Mixed Tissue enhanced skeletal muscle: 24.1;testis: 49.4 bone marrow: 10.5 CNBP CNBP1, DM2, RNF163, ZCCHC22, ZNF9 ENSG00000169714 CCHC-type zinc finger, nucleic acid binding protein 3 129169484-129183922 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA063097 Supported Nucleus
Cytosol Pancreatic cancer:3.51e-4 (unfavourable) Expressed in all Expressed in all ovary: 473.3 CNOT3 KIAA0691, LENG2, NOT3, NOT3H ENSG00000088038 CCR4-NOT transcription complex, subunit 3 19 54137728-54155681 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA006408 Approved Approved Cytosol Liver cancer:2.22e-4 (unfavourable), Renal cancer:2.77e-4 (unfavourable) Expressed in all Expressed in all testis: 36.1 CNTRL CEP1, CEP110 ENSG00000119397 Centriolin 9 121074863-121177610 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA020468, HPA020480, HPA051583 Approved Supported Centrosome
Cytosol Head and neck cancer:9.21e-5 (favourable) Expressed in all Tissue enhanced testis: 65.6 lymph node: 29.3 COL1A1 OI4 ENSG00000108821 Collagen, type I, alpha 1 17 50183289-50201632 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA008405, HPA011795 Uncertain Approved Vesicles
Cytosol Renal cancer:7.19e-12 (unfavourable), Lung cancer:4.43e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 1863.2 COL2A1 AOM, SEDC, STL1 ENSG00000139219 Collagen, type II, alpha 1 12 47972965-48004486 Cancer-related genes, Disease related genes, Predicted secreted proteins Evidence at protein level CAB002214, HPA055753 Supported Approved Nucleoplasm Mixed Group enriched 9 epididymis: 22.6;stomach: 6.0 testis: 1.6 COX6C ENSG00000164919 Cytochrome c oxidase subunit VIc 8 99873200-99894062 Cancer-related genes, Predicted membrane proteins Evidence at protein level HPA014295, CAB016244 Supported Validated Mitochondria Expressed in all Expressed in all duodenum: 349.0 CREB1 ENSG00000118260 CAMP responsive element binding protein 1 2 207529737-207603431 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB003803, HPA019150 Supported Validated Nucleoplasm Liver cancer:2.77e-5 (unfavourable) Expressed in all Expressed in all testis: 58.7 CREB3L1 OASIS ENSG00000157613 CAMP responsive element binding protein 3-like 1 11 46277661-46321422 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA024069, CAB026151 Supported Uncertain Plasma membrane
Cytosol Renal cancer:2.97e-4 (unfavourable), Endometrial cancer:3.92e-4 (favourable), Thyroid cancer:8.59e-4 (unfavourable) Expressed in all Mixed stomach: 66.1 CREB3L2 BBF2H7, TCAG_1951439 ENSG00000182158 CAMP responsive element binding protein 3-like 2 7 137874979-138002067 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA015068, HPA015534 Uncertain Supported Nucleoplasm
Endoplasmic reticulum Expressed in all Expressed in all thyroid gland: 109.9 CREBBP CBP, KAT3A, RSTS, RTS ENSG00000005339 CREB binding protein 16 3725054-3880726 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004212, HPA055861 Supported Validated Nucleoplasm
Nuclear bodies Renal cancer:6.24e-5 (favourable) Expressed in all Expressed in all testis: 60.4 CRTC1 FLJ14027, KIAA0616, MECT1, TORC1 ENSG00000105662 CREB regulated transcription coactivator 1 19 18683677-18782333 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA022035 Approved Supported Nucleoplasm
Nuclear bodies
Plasma membrane
Cytosol Pancreatic cancer:1.80e-5 (favourable), Renal cancer:3.83e-5 (favourable) Expressed in all Expressed in all cerebral cortex: 23.8 CRTC3 FLJ21868 ENSG00000140577 CREB regulated transcription coactivator 3 15 90529925-90645345 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA043735, HPA063691 Uncertain Validated Nucleoplasm
Cytosol Expressed in all Expressed in all ovary: 50.5 CSF3R CD114, GCSFR ENSG00000119535 Colony stimulating factor 3 receptor (granulocyte) 1 36466043-36483278 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB017116, HPA048086 Supported Testis cancer:3.79e-4 (unfavourable), Renal cancer:5.72e-4 (unfavourable) Mixed Tissue enhanced appendix: 215.2;bone marrow: 243.8;placenta: 147.0 spleen: 98.2 CTNNB1 armadillo, beta-catenin, CTNNB ENSG00000168036 Catenin (cadherin-associated protein), beta 1, 88kDa 3 41194837-41260096 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000108, CAB001950, HPA029159, HPA029160 Supported Validated Plasma membrane Colorectal cancer:7.54e-4 (favourable) Expressed in all Expressed in all cervix, uterine: 285.2 CUX1 CASP, CDP, CDP/Cut, CDP/Cux, CDP1, Clox, CUT, CUTL1, CUX, Cux/CDP, GOLIM6 ENSG00000257923 Cut-like homeobox 1 7 101815904-102283957 Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA003277, HPA003317 Approved Supported Nucleoplasm
Golgi apparatus Renal cancer:5.72e-7 (favourable), Glioma:9.90e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 82.3 CYLD CYLD1, KIAA0849, USPL2 ENSG00000083799 Cylindromatosis (turban tumor syndrome) 16 50742050-50801935 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB011713, HPA050095 Approved Supported Nucleoplasm
Microtubule organizing center Expressed in all Expressed in all testis: 70.2 DAXX DAP6 ENSG00000204209 Death-domain associated protein 6 33318558-33329269 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB002224, HPA008736, HPA008797, CAB025546, HPA065779 Supported Validated Nucleus
Nuclear bodies Renal cancer:6.32e-7 (unfavourable), Breast cancer:6.05e-4 (favourable) Expressed in all Mixed epididymis: 19.0 DCTN1 ENSG00000204843 Dynactin 1 2 74361154-74392087 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009108, HPA034635 Approved Supported Actin filaments
Centrosome
Cytosol Renal cancer:2.34e-7 (favourable) Expressed in all Expressed in all cerebral cortex: 210.5 DDB2 DDBB, FLJ34321, UV-DDB2, XPE ENSG00000134574 Damage-specific DNA binding protein 2, 48kDa 11 47214465-47239240 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB025912, HPA058406 Supported Supported Nucleoplasm
Cell Junctions Endometrial cancer:1.20e-4 (favourable), Cervical cancer:1.58e-4 (favourable), Breast cancer:7.29e-4 (favourable) Expressed in all Expressed in all skin: 53.8 DDIT3 CHOP, CHOP10, GADD153 ENSG00000175197 DNA-damage-inducible transcript 3 12 57516588-57520517 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA058416, HPA068416 Approved Approved Nucleoplasm Liver cancer:6.55e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 263.1 DDX10 HRH-J8 ENSG00000178105 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 11 108665025-108940930 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA004691 Approved Approved Nucleoli Renal cancer:2.14e-5 (favourable), Liver cancer:2.52e-5 (unfavourable), Pancreatic cancer:5.75e-4 (unfavourable) Expressed in all Expressed in all testis: 29.1 DDX5 G17P1, HLR1, p68 ENSG00000108654 DEAD (Asp-Glu-Ala-Asp) box helicase 5 17 64499616-64508199 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB005868, HPA020043 Supported Validated Nucleoplasm Colorectal cancer:2.12e-4 (favourable) Expressed in all Expressed in all smooth muscle: 594.4 DDX6 HLR2, RCK ENSG00000110367 DEAD (Asp-Glu-Ala-Asp) box helicase 6 11 118747766-118791149 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004668, HPA024201, HPA026644 Approved Supported Cytosol
Cytoplasmic bodies Liver cancer:6.56e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 65.6 DEK D6S231E ENSG00000124795 DEK proto-oncogene 6 18223868-18264823 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB015226, HPA054505, HPA057799 Supported Validated Nucleus Renal cancer:3.45e-4 (unfavourable), Liver cancer:9.65e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 158.3 DICER1 Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1 ENSG00000100697 Dicer 1, ribonuclease type III 14 95086228-95158010 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA000694, CAB068185 Approved Supported Cytosol Expressed in all Expressed in all placenta: 32.2 DNM2 CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII ENSG00000079805 Dynamin 2 19 10718079-10833488 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA054246 Supported Approved Golgi apparatus
Cytosol Liver cancer:3.63e-4 (unfavourable), Head and neck cancer:8.91e-4 (favourable) Expressed in all Expressed in all colon: 106.7 DNMT3A ENSG00000119772 DNA (cytosine-5-)-methyltransferase 3 alpha 2 25227855-25342590 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB009469, HPA026588 Approved Supported Nucleoplasm Pancreatic cancer:1.18e-4 (favourable), Endometrial cancer:1.55e-4 (unfavourable), Liver cancer:1.58e-4 (unfavourable), Renal cancer:2.49e-4 (unfavourable) Expressed in all Expressed in all placenta: 22.6 EBF1 EBF, OLF1 ENSG00000164330 Early B-cell factor 1 5 158695916-159099761 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA061169 Approved Nucleoplasm
Vesicles Renal cancer:9.62e-7 (unfavourable), Stomach cancer:7.80e-4 (unfavourable) Mixed Tissue enhanced adipose tissue: 41.6 placenta: 16.6 ECT2L ARHGEF32, C6orf91, FBXO49, LFDH ENSG00000203734 Epithelial cell transforming 2 like 6 138795926-138904070 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA035488 Uncertain Not detected Tissue enriched 6 fallopian tube: 18.0 lung: 2.7 EGFR ERBB, ERBB1 ENSG00000146648 Epidermal growth factor receptor 7 55019021-55256620 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB000035, HPA001200, HPA018530, CAB068186, CAB073534 Supported Validated Plasma membrane Urothelial cancer:2.04e-5 (unfavourable) Expressed in all Tissue enhanced placenta: 97.3 skin: 58.9 EIF3E eIF3-p48, eIF3e, EIF3S6, INT6 ENSG00000104408 Eukaryotic translation initiation factor 3, subunit E 8 108201216-108435333 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA023973 Approved Validated Nuclear bodies
Cytosol Renal cancer:3.06e-7 (unfavourable) Expressed in all Expressed in all ovary: 729.0 EIF4A2 BM-010, DDX2B, EIF4A, EIF4F ENSG00000156976 Eukaryotic translation initiation factor 4A2 3 186783205-186789900 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB011690, HPA068286 Uncertain Approved Cytosol Expressed in all Expressed in all ovary: 724.4 ELF4 ELFR, MEF ENSG00000102034 E74-like factor 4 (ets domain transcription factor) X 130064874-130110716 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA058595, HPA060277 Approved Supported Nucleoplasm
Nuclear bodies Renal cancer:6.49e-6 (unfavourable), Urothelial cancer:1.42e-4 (favourable) Expressed in all Mixed placenta: 34.7 ELK4 SAP1 ENSG00000158711 ELK4, ETS-domain protein (SRF accessory protein 1) 1 205597556-205631962 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA028863 Uncertain Supported Nucleoplasm Renal cancer:2.94e-6 (unfavourable), Head and neck cancer:4.65e-4 (favourable) Expressed in all Expressed in all prostate: 41.5 ELL C19orf17, ELL1, Men, PPP1R68 ENSG00000105656 Elongation factor RNA polymerase II 19 18442663-18522127 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA046076 Uncertain Expressed in all Expressed in all testis: 25.3 ELN SVAS, WBS, WS ENSG00000049540 Elastin 7 74027789-74069907 Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins Evidence at protein level CAB010750, HPA018111, HPA056941 Supported Approved Plasma membrane Thyroid cancer:6.29e-4 (unfavourable) Expressed in all Mixed smooth muscle: 124.5 EML4 C2orf2, ELP120, ROPP120 ENSG00000143924 Echinoderm microtubule associated protein like 4 2 42169350-42332548 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA036687, HPA036688, HPA065337 Supported Supported Intermediate filaments
Microtubules
Cytosol Expressed in all Mixed placenta: 50.1 EP300 KAT3B, p300 ENSG00000100393 E1A binding protein p300 22 41091786-41180079 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB000146, HPA003128, HPA004112 Supported Validated Nucleoplasm Renal cancer:7.45e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 45.3 EPS15 AF-1P, MLLT5 ENSG00000085832 Epidermal growth factor receptor pathway substrate 15 1 51354263-51519328 Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA008451, CAB010164 Approved Validated Vesicles
Cytosol Cervical cancer:6.44e-4 (unfavourable) Expressed in all Expressed in all testis: 84.3 ERBB2 CD340, HER-2, HER2, NEU, NGL ENSG00000141736 Erb-b2 receptor tyrosine kinase 2 17 39687914-39730426 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB000043, HPA001060, HPA001338, HPA001383, CAB020416, CAB062555 Approved Supported Plasma membrane
Cytosol Renal cancer:2.41e-14 (favourable), Endometrial cancer:8.99e-8 (unfavourable), Pancreatic cancer:9.17e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 122.9 ERBB3 HER3, LCCS2 ENSG00000065361 Erb-b2 receptor tyrosine kinase 3 12 56079857-56103505 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB025331, HPA045396 Uncertain Approved Plasma membrane
Actin filaments Expressed in all Mixed small intestine: 88.5 ERC1 CAST2, ELKS, KIAA1081, MGC12974, RAB6IP2 ENSG00000082805 ELKS/RAB6-interacting/CAST family member 1 12 990509-1495933 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA019513, HPA019523, HPA024130 Approved Supported Vesicles
Plasma membrane
Cytosol Urothelial cancer:7.01e-4 (unfavourable) Expressed in all Mixed parathyroid gland: 17.1 ERCC2 EM9, MAG, MGC102762, MGC126218, MGC126219, TFIIH, XPD ENSG00000104884 Excision repair cross-complementation group 2 19 45349837-45370918 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB005375, HPA038057, HPA069266 Approved Supported Nucleoplasm Pancreatic cancer:3.26e-4 (favourable) Expressed in all Expressed in all testis: 16.2 ERCC3 BTF2, GTF2H, RAD25, TFIIH, XPB ENSG00000163161 Excision repair cross-complementation group 3 2 127257290-127294176 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB037153, HPA046077 Approved Validated Nucleoplasm Liver cancer:1.62e-7 (unfavourable), Renal cancer:4.30e-6 (unfavourable) Expressed in all Expressed in all testis: 54.8 ERCC4 FANCQ, RAD1, XPF ENSG00000175595 Excision repair cross-complementation group 4 16 13920157-13952345 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000156, HPA045828 Approved Supported Nucleoplasm
Nuclear bodies Expressed in all Mixed testis: 10.7 ERCC5 ERCM2, XPGC ENSG00000134899 Excision repair cross-complementation group 5 13 102844844-102876001 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA045845, HPA050374 Supported Approved Nucleoplasm Renal cancer:2.96e-6 (unfavourable), Urothelial cancer:6.82e-4 (favourable) Expressed in all Expressed in all spleen: 38.2 ERG erg-3, p55 ENSG00000157554 V-ets avian erythroblastosis virus E26 oncogene homolog 21 38380027-38661780 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB018377, HPA046598 Approved Approved Nucleoplasm
Cytosol Cervical cancer:6.18e-6 (unfavourable), Renal cancer:3.94e-4 (unfavourable) Expressed in all Expressed in all spleen: 37.3 ESR1 Era, ESR, NR3A1 ENSG00000091831 Estrogen receptor 1 6 151656691-152129619 Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000037, HPA000449, HPA000450, CAB055099, CAB072858 Supported Approved Nucleus
Vesicles Endometrial cancer:5.47e-7 (favourable) Group enriched Group enriched 8 breast: 37.4;cervix, uterine: 127.3;endometrium: 179.7;fallopian tube: 105.5;smooth muscle: 75.9 seminal vesicle: 13.5 ETNK1 EKI, EKI1 ENSG00000139163 Ethanolamine kinase 1 12 22625075-22690665 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010712, HPA029407 Approved Supported Nucleoplasm
Plasma membrane
Cytosol Urothelial cancer:1.75e-4 (favourable), Liver cancer:5.85e-4 (unfavourable) Expressed in all Expressed in all stomach: 45.8 ETV1 ER81 ENSG00000006468 Ets variant 1 7 13891228-13991425 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA077249 Approved Nucleoplasm Expressed in all Tissue enhanced cerebral cortex: 106.6 lung: 43.3 ETV4 E1A-F, E1AF, PEA3 ENSG00000175832 Ets variant 4 17 43527844-43579620 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005768 Approved Supported Nucleoli Liver cancer:2.48e-4 (unfavourable), Thyroid cancer:7.60e-4 (favourable) Expressed in all Tissue enhanced parathyroid gland: 29.7 cerebral cortex: 13.7 ETV5 ERM ENSG00000244405 Ets variant 5 3 186046308-186110318 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB009590, HPA063065 Approved Supported Nucleoplasm Liver cancer:7.85e-9 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 112.2 cerebral cortex: 74.9 ETV6 TEL ENSG00000139083 Ets variant 6 12 11649854-11895402 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA000264 Supported Validated Nucleoli
Cytosol Renal cancer:4.66e-8 (unfavourable), Urothelial cancer:1.54e-5 (favourable), Pancreatic cancer:9.38e-5 (unfavourable) Expressed in all Expressed in all bone marrow: 26.5 EWSR1 EWS ENSG00000182944 EWS RNA-binding protein 1 22 29268009-29300525 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004230, HPA051771, HPA062953 Supported Validated Nucleus
Nucleoli Liver cancer:1.27e-6 (unfavourable), Renal cancer:1.21e-5 (unfavourable) Expressed in all Expressed in all testis: 213.0 EXT1 LGCR, LGS, ttv ENSG00000182197 Exostosin glycosyltransferase 1 8 117794490-118111853 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA044394 Uncertain Lung cancer:1.20e-5 (unfavourable), Thyroid cancer:4.64e-4 (unfavourable), Cervical cancer:7.04e-4 (unfavourable) Expressed in all Expressed in all duodenum: 32.5 EXT2 SOTV ENSG00000151348 Exostosin glycosyltransferase 2 11 44095549-44245429 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA078409 Supported Golgi apparatus Renal cancer:5.36e-6 (unfavourable), Head and neck cancer:2.50e-4 (unfavourable) Expressed in all Expressed in all placenta: 89.9 EZH2 ENX-1, EZH1, KMT6, KMT6A ENSG00000106462 Enhancer of zeste 2 polycomb repressive complex 2 subunit 7 148807383-148884321 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB009589, HPA029131 Supported Supported Nucleoplasm Renal cancer:8.18e-12 (unfavourable), Liver cancer:2.11e-6 (unfavourable), Melanoma:1.96e-4 (unfavourable), Stomach cancer:6.97e-4 (favourable) Expressed in all Tissue enhanced testis: 50.4 bone marrow: 30.0 EZR VIL2 ENSG00000092820 Ezrin 6 158765741-158819412 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004035, HPA021616, CAB047324 Supported Validated Plasma membrane Renal cancer:9.56e-8 (favourable), Pancreatic cancer:1.70e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 528.6 FAM131B KIAA0773 ENSG00000159784 Family with sequence similarity 131, member B 7 143353400-143362770 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA021371, HPA029992 Validated Nucleoplasm
Cytosol Tissue enriched Tissue enriched 9 cerebral cortex: 64.0 parathyroid gland: 7.4 FAM46C FLJ20202 ENSG00000183508 Family with sequence similarity 46, member C 1 117605934-117628372 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA054049 Uncertain Approved Nucleoplasm Renal cancer:2.77e-5 (favourable), Endometrial cancer:3.75e-5 (favourable) Expressed in all Mixed testis: 58.4 FANCA FA-H, FAA, FACA, FAH, FANCH ENSG00000187741 Fanconi anemia, complementation group A 16 89737549-89816657 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA063236 Supported Nucleus Mixed Mixed testis: 19.5 FANCC FA3, FAC, FACC ENSG00000158169 Fanconi anemia, complementation group C 9 95099054-95317709 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB017793, HPA030771 Approved Supported Nucleoplasm Renal cancer:6.03e-6 (favourable) Expressed in all Mixed testis: 18.1 FANCD2 FA-D2, FACD, FAD, FANCD ENSG00000144554 Fanconi anemia, complementation group D2 3 10026414-10101930 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB016117, HPA063742 Approved Supported Nucleus
Nuclear bodies
Cytosol Ovarian cancer:5.00e-5 (unfavourable) Expressed in all Mixed testis: 21.7 FANCE FACE, FAE ENSG00000112039 Fanconi anemia, complementation group E 6 35452361-35467103 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB014893 Supported Supported Nucleoplasm Liver cancer:2.08e-9 (unfavourable), Endometrial cancer:6.25e-4 (unfavourable) Expressed in all Mixed skin: 16.2 FANCG FAG, XRCC9 ENSG00000221829 Fanconi anemia, complementation group G 9 35073835-35080016 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB008105, HPA045335 Approved Supported Nucleoli
Plasma membrane
Cytosol Renal cancer:2.38e-7 (unfavourable), Liver cancer:2.02e-4 (unfavourable) Expressed in all Mixed fallopian tube: 8.5 FAS APO-1, APT1, CD95, FAS1, TNFRSF6 ENSG00000026103 Fas cell surface death receptor 10 88990531-89015785 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA027444 Approved Approved Plasma membrane
Cytosol Expressed in all Mixed lung: 39.5 FBXO11 FBX11, UBR6 ENSG00000138081 F-box protein 11 2 47789316-47905793 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002690 Uncertain Supported Nucleus Expressed in all Expressed in all testis: 74.9 FBXW7 AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10 ENSG00000109670 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 4 152321259-152536101 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB013793, CAB029987 Supported Supported Nucleoplasm
Vesicles Renal cancer:1.52e-4 (unfavourable) Expressed in all Expressed in all skin: 87.7 FCGR2B CD32, CD32B, FCG2, FCGR2 ENSG00000072694 Fc fragment of IgG, low affinity IIb, receptor (CD32) 1 161663147-161678654 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level CAB007796, HPA014730 Supported Renal cancer:8.82e-4 (unfavourable) Mixed Tissue enriched 16 placenta: 571.2 adipose tissue: 36.3 FCRL4 CD307d, FCRH4, IGFP2, IRTA1 ENSG00000163518 Fc receptor-like 4 1 157573749-157598080 Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins Evidence at protein level HPA054030 Approved Not detected Group enriched 5 appendix: 3.7;lymph node: 4.5;tonsil: 10.1 spleen: 1.2 FEV Pet-1 ENSG00000163497 FEV (ETS oncogene family) 2 218981087-218985657 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA067679 Supported Approved Nuclear speckles Pancreatic cancer:4.85e-4 (favourable) Group enriched Tissue enhanced adrenal gland: 2.1;duodenum: 3.0;stomach: 2.4 prostate: 1.9 FGFR1 BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM ENSG00000077782 Fibroblast growth factor receptor 1 8 38411138-38468834 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB033614, HPA056402, HPA076274 Approved Approved Nucleoli Expressed in all Expressed in all gallbladder: 109.6 FGFR1OP FOP ENSG00000213066 FGFR1 oncogene partner 6 166999182-167052713 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA071876 Supported Centrosome Renal cancer:7.32e-4 (unfavourable) Expressed in all Expressed in all testis: 104.8 FGFR2 BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 ENSG00000066468 Fibroblast growth factor receptor 2 10 121478334-121598458 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB010886, HPA035305, HPA056562 Uncertain Approved Vesicles Cervical cancer:8.79e-4 (favourable), Head and neck cancer:9.32e-4 (favourable) Expressed in all Mixed skin: 97.5 FGFR3 ACH, CD333, CEK2, JTK4 ENSG00000068078 Fibroblast growth factor receptor 3 4 1793307-1808872 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB004231, HPA067204 Supported Supported Endoplasmic reticulum Endometrial cancer:3.77e-4 (unfavourable) Expressed in all Tissue enriched 7 skin: 334.6 cerebral cortex: 49.7 FGFR4 CD334, JTK2 ENSG00000160867 Fibroblast growth factor receptor 4 5 177086886-177098144 Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB005196, HPA027273, HPA027369, HPA028251 Approved Mixed Tissue enhanced lung: 39.1 duodenum: 22.0 FH fumarase ENSG00000091483 Fumarate hydratase 1 241497603-241519761 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB017785, HPA025770, HPA025948, HPA027341 Supported Approved Validated Mitochondria Renal cancer:2.76e-7 (favourable) Expressed in all Expressed in all liver: 141.9 FHIT AP3Aase, FRA3B ENSG00000189283 Fragile histidine triad 3 59749310-61251459 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB002684, HPA018840, HPA018909 Supported Approved Nucleoli fibrillar center
Plasma membrane Renal cancer:1.36e-4 (favourable) Mixed Expressed in all kidney: 26.6 FIP1L1 DKFZp586K0717, FIP1 ENSG00000145216 Factor interacting with PAPOLA and CPSF1 4 53377643-53460861 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA037475, HPA058202 Supported Validated Nucleoplasm Liver cancer:1.51e-4 (unfavourable) Expressed in all Expressed in all testis: 68.7 FLCN BHD, MGC17998, MGC23445 ENSG00000154803 Folliculin 17 17212212-17237188 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB015158, HPA028760 Supported Supported Plasma membrane
Cytosol Pancreatic cancer:4.49e-4 (favourable) Expressed in all Expressed in all endometrium: 30.7 FLI1 EWSR2, SIC-1 ENSG00000151702 Fli-1 proto-oncogene, ETS transcription factor 11 128686535-128813267 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA073099 Supported Nucleus
Nuclear bodies Renal cancer:4.60e-4 (unfavourable) Expressed in all Tissue enhanced spleen: 48.1 placenta: 16.2 FLT3 CD135, FLK2, STK1 ENSG00000122025 Fms-related tyrosine kinase 3 13 28003274-28100592 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA047539 Approved Endoplasmic reticulum Tissue enhanced Tissue enhanced lymph node: 7.1;spleen: 7.8 appendix: 4.0 FLT4 PCL, VEGFR3 ENSG00000037280 Fms-related tyrosine kinase 4 5 180601506-180649624 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB000099 Supported Nuclear speckles
Plasma membrane
Cell Junctions Expressed in all Mixed spleen: 18.6 FNBP1 FBP17, KIAA0554 ENSG00000187239 Formin binding protein 1 9 129887187-130043194 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019691, HPA022119 Supported Renal cancer:8.45e-5 (unfavourable) Expressed in all Expressed in all lymph node: 91.9 FOXA1 HNF3A ENSG00000129514 Forkhead box A1 14 37589984-37596059 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB011595, HPA050505 Supported Supported Nucleoplasm
Nucleoli fibrillar center Urothelial cancer:1.00e-4 (favourable) Tissue enhanced Tissue enhanced prostate: 145.4 breast: 36.3 FOXL2 BPES, BPES1 ENSG00000183770 Forkhead box L2 3 138944224-138947140 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA069613 Supported Supported Nucleus
Cytokinetic bridge Mixed Tissue enhanced endometrium: 12.1;ovary: 29.6;parathyroid gland: 24.2 fallopian tube: 7.6 FOXO1 FKH1, FKHR, FOXO1A ENSG00000150907 Forkhead box O1 13 40555667-40666597 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001252, CAB022326 Approved Approved Supported Nucleoplasm
Cytosol Renal cancer:1.33e-5 (favourable), Liver cancer:3.74e-4 (favourable) Expressed in all Expressed in all ovary: 80.5 FOXO3 AF6q21, FKHRL1, FOXO2, FOXO3A ENSG00000118689 Forkhead box O3 6 108559835-108684774 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004074, HPA063104 Supported Validated Nucleus Expressed in all Expressed in all ovary: 54.9 FOXO4 AFX1, MLLT7 ENSG00000184481 Forkhead box O4 X 71096197-71103535 Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors Evidence at protein level HPA039560, HPA040232 Approved Supported Nuclear speckles
Cytosol Renal cancer:3.46e-4 (favourable), Head and neck cancer:4.61e-4 (favourable) Expressed in all Expressed in all placenta: 171.9 FOXP1 12CC4, hFKH1B, HSPC215, QRF1 ENSG00000114861 Forkhead box P1 3 70954693-71583989 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003876, CAB011501 Supported Validated Nucleoplasm Expressed in all Expressed in all ovary: 39.5 FSTL3 FLRG, FSRP ENSG00000070404 Follistatin-like 3 (secreted glycoprotein) 19 676365-683399 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB024899, HPA045378 Approved Approved Nucleoplasm Lung cancer:4.61e-7 (unfavourable), Ovarian cancer:1.65e-4 (unfavourable), Colorectal cancer:3.01e-4 (unfavourable), Endometrial cancer:3.03e-4 (unfavourable) Expressed in all Expressed in all placenta: 259.7 FUBP1 FBP, FUBP ENSG00000162613 Far upstream element (FUSE) binding protein 1 1 77944055-77979110 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006149 Supported Validated Nucleoplasm Liver cancer:9.83e-9 (unfavourable) Expressed in all Expressed in all parathyroid gland: 68.1 FUS ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS ENSG00000089280 FUS RNA binding protein 16 31180110-31194871 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA008784, CAB033036, CAB058691 Supported Validated Nucleoplasm Liver cancer:4.38e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 146.2 GAS7 KIAA0394, MGC1348 ENSG00000007237 Growth arrest-specific 7 17 9910609-10198551 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA004838, HPA064678 Supported Approved Plasma membrane
Actin filaments
Focal adhesion sites Urothelial cancer:6.89e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 155.2 cervix, uterine: 47.5 GATA1 ERYF1, GATA-1, GF1, NF-E1, NFE1 ENSG00000102145 GATA binding protein 1 (globin transcription factor 1) X 48786554-48794311 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA000232, HPA000233, CAB009195 Supported Not detected Tissue enriched 18 bone marrow: 33.3 testis: 1.8 GATA2 NFE1B ENSG00000179348 GATA binding protein 2 3 128479427-128493185 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005633, CAB024847 Approved Supported Nucleoplasm Urothelial cancer:5.22e-5 (favourable), Renal cancer:2.04e-4 (favourable) Expressed in all Tissue enhanced seminal vesicle: 76.1 prostate: 60.0 GATA3 HDR ENSG00000107485 GATA binding protein 3 10 8053604-8075198 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB016217, HPA029730, HPA029731 Supported Supported Nucleoplasm Renal cancer:3.13e-4 (unfavourable) Group enriched Tissue enhanced parathyroid gland: 231.0;skin: 149.3 placenta: 44.1 GMPS ENSG00000163655 Guanine monophosphate synthase 3 155870536-155944026 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA046630 Approved Cytosol Liver cancer:8.73e-7 (unfavourable), Endometrial cancer:5.54e-5 (unfavourable), Pancreatic cancer:1.04e-4 (unfavourable) Expressed in all Expressed in all testis: 180.7 GNA11 FBH, FBH2, FHH2, HHC2 ENSG00000088256 Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 19 3094410-3124004 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA048886 Approved Renal cancer:1.48e-11 (favourable), Liver cancer:4.86e-4 (unfavourable) Expressed in all Expressed in all small intestine: 159.0 GNAQ G-ALPHA-q, GAQ ENSG00000156052 Guanine nucleotide binding protein (G protein), q polypeptide 9 77716087-78031458 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB010036, HPA048886 Uncertain Approved Nuclear speckles
Plasma membrane
Cytosol Renal cancer:1.11e-7 (favourable) Expressed in all Expressed in all cerebral cortex: 85.1 GNAS GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI ENSG00000087460 GNAS complex locus 20 58839718-58911192 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB010337, HPA018122, HPA027478, HPA028386 Uncertain Supported Nucleoplasm
Plasma membrane
Cytosol Renal cancer:3.49e-4 (unfavourable), Ovarian cancer:8.76e-4 (favourable) Expressed in all Expressed in all thyroid gland: 1471.9 GOLGA5 golgin-84, GOLIM5, ret-II, rfg5 ENSG00000066455 Golgin A5 14 92794231-92839963 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA000992, HPA063876 Supported Supported Supported Golgi apparatus Expressed in all Expressed in all epididymis: 64.2 GOPC CAL, dJ94G16.2, FIG, GOPC1, PIST ENSG00000047932 Golgi-associated PDZ and coiled-coil motif containing 6 117560269-117602542 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA019477, HPA024018 Approved Validated Golgi apparatus
Cytosol Expressed in all Expressed in all parathyroid gland: 47.0 GPC3 DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1 ENSG00000147257 Glypican 3 X 133535745-133985895 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006316 Approved Plasma membrane Stomach cancer:4.83e-4 (unfavourable) Expressed in all Tissue enriched 6 placenta: 838.1 lung: 130.8 GPHN KIAA1385 ENSG00000171723 Gephyrin 14 66507407-67181803 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA003116, CAB004419, HPA024694 Supported Uncertain Cytoplasmic bodies Renal cancer:5.25e-12 (favourable), Urothelial cancer:4.61e-5 (unfavourable) Expressed in all Expressed in all cerebral cortex: 30.5 GRIN2A GluN2A, NMDAR2A ENSG00000183454 Glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16 9753404-10182754 Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins Evidence at protein level CAB022725 Supported Mixed Tissue enriched 5 cerebral cortex: 25.0 testis: 4.7 H3F3A H3.3A, H3F3 ENSG00000163041 H3 histone, family 3A 1 226061851-226072001 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB011481, CAB037178, HPA042570 Supported Supported Nucleoplasm Renal cancer:1.21e-6 (unfavourable) Expressed in all Expressed in all bone marrow: 1218.1 H3F3B H3.3B ENSG00000132475 H3 histone, family 3B (H3.3B) 17 75776434-75785893 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB037166, CAB037187, CAB037221, HPA042570 Supported Validated Nucleoplasm Expressed in all Expressed in all bone marrow: 2838.4 HERPUD1 HERP, KIAA0025, Mif1, SUP ENSG00000051108 Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 16 56932048-56944863 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB037041, CAB037104, HPA040754, HPA041219 Approved Uncertain Plasma membrane
Cytosol Renal cancer:1.41e-9 (favourable) Expressed in all Expressed in all prostate: 379.0 HEY1 bHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1 ENSG00000164683 Hes-related family bHLH transcription factor with YRPW motif 1 8 79764010-79767863 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA055599, HPA063472 Uncertain Approved Nucleoplasm
Nuclear membrane
Cytosol Expressed in all Tissue enhanced cerebral cortex: 96.6 placenta: 28.7 HIP1 ILWEQ ENSG00000127946 Huntingtin interacting protein 1 7 75533300-75738962 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA013606, CAB015334, CAB016402, HPA017964 Supported Validated Vesicles Expressed in all Mixed testis: 35.1 HIST1H3B H3/l, H3FL ENSG00000274267 Histone cluster 1, H3b 6 26031650-26032060 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA042570 Supported Mixed Tissue enriched 6 bone marrow: 6.1 lymph node: 0.9 HIST1H4I H4/m, H4FM ENSG00000276180 Histone cluster 1, H4i 6 27138588-27139881 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA042201 Supported Renal cancer:1.32e-5 (unfavourable), Cervical cancer:9.70e-4 (favourable) Expressed in all Mixed prostate: 12.1 HLA-A ENSG00000206503 Major histocompatibility complex, class I, A 6 29941260-29945884 Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB078470 Supported Golgi apparatus
Plasma membrane Ovarian cancer:6.47e-4 (favourable), Endometrial cancer:9.59e-4 (favourable) Expressed in all Mixed gallbladder: 342.4 HLF MGC33822 ENSG00000108924 Hepatic leukemia factor 17 55265012-55325065 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA068156, HPA071210 Validated Nucleus Lung cancer:2.71e-7 (favourable), Renal cancer:3.55e-6 (favourable), Head and neck cancer:1.88e-4 (favourable) Tissue enhanced Mixed cerebral cortex: 65.6 HMGA1 HMGIY ENSG00000137309 High mobility group AT-hook 1 6 34236873-34246231 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB032200 Uncertain Approved Nucleus
Nucleoli Liver cancer:1.29e-6 (unfavourable), Lung cancer:3.36e-4 (unfavourable), Endometrial cancer:7.13e-4 (unfavourable), Pancreatic cancer:8.71e-4 (unfavourable) Expressed in all Expressed in all lymph node: 165.8 HMGA2 BABL, HMGIC, LIPO ENSG00000149948 High mobility group AT-hook 2 12 65824131-65966295 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017809, HPA039076 Approved Supported Nucleus
Nucleoli Urothelial cancer:2.86e-4 (unfavourable), Head and neck cancer:4.79e-4 (unfavourable) Mixed Mixed testis: 3.7 HNF1A HCF-1A, HNF1, LFB1, MODY3, TCF1 ENSG00000135100 HNF1 homeobox A 12 120978543-121002512 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB010430, HPA035231 Supported Supported Nucleoplasm Mixed Tissue enhanced duodenum: 15.9;kidney: 10.1;small intestine: 16.0 liver: 5.8 HNRNPA2B1 HNRPA2B1 ENSG00000122566 Heterogeneous nuclear ribonucleoprotein A2/B1 7 26189927-26201529 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA001666, HPA005812, CAB012403, HPA065537 Supported Validated Nucleoplasm Liver cancer:1.03e-6 (unfavourable), Renal cancer:8.01e-5 (unfavourable), Prostate cancer:5.12e-4 (unfavourable) Expressed in all Expressed in all lymph node: 762.7 HOOK3 HK3 ENSG00000168172 Hook microtubule-tethering protein 3 8 42896932-43030539 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA024756 Approved Supported Golgi apparatus
Microtubule organizing center
Cytosol Renal cancer:1.32e-4 (unfavourable) Expressed in all Mixed thyroid gland: 36.4 HOXA11 HOX1, HOX1I ENSG00000005073 Homeobox A11 7 27181510-27185223 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA006770, HPA035623 Supported Supported Nucleoplasm Renal cancer:2.57e-5 (unfavourable) Mixed Tissue enhanced endometrium: 96.0;smooth muscle: 67.7 cervix, uterine: 18.3 HOXA13 HOX1, HOX1J ENSG00000106031 Homeobox A13 7 27193503-27200106 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA046098 Approved Nucleoplasm
Intermediate filaments Tissue enhanced Tissue enhanced cervix, uterine: 33.9;placenta: 24.3;prostate: 36.5;seminal vesicle: 32.2 rectum: 13.3 HOXA9 HOX1, HOX1G ENSG00000078399 Homeobox A9 7 27162435-27175180 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA061982 Uncertain Supported Nucleus Mixed Mixed kidney: 12.5 HOXC11 HOX3H ENSG00000123388 Homeobox C11 12 53973126-53977643 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA038291 Uncertain Supported Nucleoplasm
Cytosol Mixed Tissue enhanced skin: 2.3 testis: 1.2 HOXC13 HOX3, HOX3G ENSG00000123364 Homeobox C13 12 53938765-53946544 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA051634 Supported Mixed Tissue enriched 7 skin: 4.6 breast: 0.6 HOXD11 HOX4, HOX4F ENSG00000128713 Homeobox D11 2 176104216-176109754 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA055155 Approved Nucleoplasm Mixed Tissue enhanced endometrium: 5.9 colon,smooth muscle: 1.6 HOXD13 HOX4I, SPD ENSG00000128714 Homeobox D13 2 176092891-176095938 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA064064 Supported Nucleus Colorectal cancer:6.95e-5 (unfavourable) Mixed Group enriched 8 cervix, uterine: 7.9;colon: 5.1;prostate: 18.4;rectum: 9.6;seminal vesicle: 24.4 urinary bladder: 1.6 HRAS HRAS1 ENSG00000174775 Harvey rat sarcoma viral oncogene homolog 11 532242-537287 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB002015, HPA049830 Approved Liver cancer:2.32e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 25.0 HSP90AA1 FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA ENSG00000080824 Heat shock protein 90kDa alpha (cytosolic), class A member 1 14 102080738-102139699 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB002058 Approved Supported Cytosol Renal cancer:1.18e-5 (favourable), Liver cancer:3.09e-5 (unfavourable), Breast cancer:5.59e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 1024.3 HSP90AB1 HSPC2, HSPCB ENSG00000096384 Heat shock protein 90kDa alpha (cytosolic), class B member 1 6 44246166-44253888 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB005230, HPA055729 Approved Validated Cytosol Ovarian cancer:4.03e-4 (favourable), Renal cancer:9.94e-4 (unfavourable) Expressed in all Expressed in all ovary: 1457.6 IDH1 ENSG00000138413 Isocitrate dehydrogenase 1 (NADP+), soluble 2 208236227-208266074 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB033218, HPA035248, HPA057936, CAB062556 Supported Approved Nuclear bodies
Cytosol Renal cancer:2.45e-5 (unfavourable), Liver cancer:6.93e-5 (unfavourable) Expressed in all Expressed in all prostate: 359.5 IDH2 ENSG00000182054 Isocitrate dehydrogenase 2 (NADP+), mitochondrial 15 90083045-90102504 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA007831 Supported Supported Mitochondria Cervical cancer:5.15e-5 (favourable) Expressed in all Expressed in all skeletal muscle: 450.2 IKBKB IKK-beta, IKK2, IKKB, NFKBIKB ENSG00000104365 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 8 42271302-42332653 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA001249, CAB004447 Approved Approved Cytosol Urothelial cancer:1.46e-6 (favourable) Expressed in all Mixed parathyroid gland: 18.8 IKZF1 hIk-1, Hs.54452, IKAROS, LyF-1, PPP1R92, ZNFN1A1 ENSG00000185811 IKAROS family zinc finger 1 (Ikaros) 7 50304124-50405101 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level CAB009247, HPA035221, HPA035222 Supported Approved Nucleoplasm
Nucleoli
Vesicles Cervical cancer:2.02e-4 (favourable), Breast cancer:4.28e-4 (favourable), Head and neck cancer:8.63e-4 (favourable) Expressed in all Tissue enhanced lymph node: 84.0;tonsil: 58.0 appendix: 55.9 IL2 IL-2, TCGF ENSG00000109471 Interleukin 2 4 122451470-122456725 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins Evidence at protein level CAB010310 Uncertain Not detected Not detected rectum,small intestine,tonsil: 0.3 IL21R CD360 ENSG00000103522 Interleukin 21 receptor 16 27402162-27452042 Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins Evidence at protein level HPA042296 Uncertain Uncertain Plasma membrane
Cytosol Head and neck cancer:7.29e-4 (favourable) Mixed Tissue enhanced appendix: 16.4;lymph node: 29.2;tonsil: 18.0 spleen: 7.7 IL6ST CD130, GP130 ENSG00000134352 Interleukin 6 signal transducer 5 55935095-55994993 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA010558, CAB025784 Uncertain Supported Golgi apparatus
Plasma membrane Renal cancer:5.05e-4 (unfavourable) Expressed in all Expressed in all placenta: 327.1 IL7R CD127 ENSG00000168685 Interleukin 7 receptor 5 35852695-35879603 Cancer-related genes, CD markers, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB010215 Approved Supported Plasma membrane Expressed in all Expressed in all appendix: 188.9 IRF4 LSIRF, MUM1 ENSG00000137265 Interferon regulatory factor 4 6 391739-411447 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002038, HPA002698, CAB013508 Supported Supported Nucleoplasm Head and neck cancer:1.64e-6 (favourable), Breast cancer:6.44e-4 (favourable) Tissue enriched Tissue enhanced lymph node: 27.4 tonsil: 25.0 JAK1 JAK1A, JAK1B, JTK3 ENSG00000162434 Janus kinase 1 1 64833229-64966504 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013088 Approved Renal cancer:2.67e-4 (favourable), Colorectal cancer:2.81e-4 (favourable), Breast cancer:9.63e-4 (favourable) Expressed in all Expressed in all lymph node: 117.1 JAK2 JTK10 ENSG00000096968 Janus kinase 2 9 4985033-5128183 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013089, HPA040820, HPA043870 Approved Supported Nucleoplasm
Plasma membrane
Focal adhesion sites Expressed in all Mixed appendix: 25.4 JAK3 JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK ENSG00000105639 Janus kinase 3 19 17824780-17848071 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level HPA070314 Supported Approved Cytosol Renal cancer:2.89e-14 (unfavourable), Cervical cancer:6.42e-5 (favourable) Expressed in all Tissue enhanced appendix: 49.9;lymph node: 47.2 tonsil: 28.2 JAZF1 DKFZp761K2222, TIP27, ZNF802 ENSG00000153814 JAZF zinc finger 1 7 27830573-28180743 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB019271, HPA066967 Approved Supported Nucleus
Nucleoli fibrillar center Expressed in all Expressed in all adrenal gland: 113.6 JUN AP-1, c-Jun ENSG00000177606 Jun proto-oncogene 1 58780788-58784327 Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB003801, CAB007780, HPA059474 Supported Validated Nucleoplasm Expressed in all Expressed in all thyroid gland: 312.9 KAT6A MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220 ENSG00000083168 K(lysine) acetyltransferase 6A 8 41929479-42051990 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017023, HPA063266, HPA065052 Supported Approved Nucleoli
Nuclear speckles
Cytosol Expressed in all Expressed in all parathyroid gland: 33.9 KAT6B Morf, MOZ2, MYST4, qkf, querkopf, ZC2HC6B ENSG00000156650 K(lysine) acetyltransferase 6B 10 74825582-75032622 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA006104 Supported Approved Nucleus
Nuclear bodies Renal cancer:4.82e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 17.0 KCNJ5 CIR, GIRK4, KATP1, Kir3.4, LQT13 ENSG00000120457 Potassium channel, inwardly rectifying subfamily J, member 5 11 128891356-128921035 Cancer-related genes, Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA014722, HPA017353, CAB022569 Supported Mixed Tissue enhanced adrenal gland: 85.2 spleen: 19.1 KDM5A JARID1A, RBBP2 ENSG00000073614 Lysine (K)-specific demethylase 5A 12 280129-389454 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA006201 Approved Nuclear bodies
Cytosol Expressed in all Expressed in all testis: 42.5 KDM5C DXS1272E, JARID1C, MRX13, SMCX, XE169 ENSG00000126012 Lysine (K)-specific demethylase 5C X 53191321-53225422 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA038244, HPA046147 Validated Nucleoplasm
Cytosol Liver cancer:2.11e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 65.5 KDM6A UTX ENSG00000147050 Lysine (K)-specific demethylase 6A X 44873177-45112602 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA000568, HPA001165, HPA002111 Supported Approved Nucleoli Expressed in all Expressed in all bone marrow: 41.1 KDR CD309, FLK1, VEGFR, VEGFR2 ENSG00000128052 Kinase insert domain receptor 4 55078477-55125589 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins Evidence at protein level CAB004028 Approved Supported Plasma membrane Renal cancer:7.26e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 118.2 thyroid gland: 54.5 KDSR DHSR, FVT1, SDR35C1 ENSG00000119537 3-ketodihydrosphingosine reductase 18 63327726-63367510 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB003673, HPA044884 Approved Renal cancer:9.53e-6 (favourable) Expressed in all Expressed in all cerebral cortex: 45.6 KIAA1549 ENSG00000122778 KIAA1549 7 138831381-138981318 Cancer-related genes, Disease related genes, Predicted membrane proteins Evidence at protein level HPA019560 Approved Approved Nuclear membrane
Intermediate filaments Renal cancer:3.93e-7 (favourable) Mixed Mixed seminal vesicle: 10.4 KIF5B KNS, KNS1 ENSG00000170759 Kinesin family member 5B 10 32009010-32056431 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009846, HPA037589, HPA037590 Approved Validated Microtubule organizing center
Cytosol Expressed in all Expressed in all parathyroid gland: 184.2 KIT C-Kit, CD117, PBT, SCFR ENSG00000157404 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4 54657918-54740715 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins Evidence at protein level CAB003288, HPA004471, CAB068253, CAB072867, HPA073252 Supported Supported Plasma membrane Renal cancer:5.63e-4 (favourable) Mixed Tissue enhanced breast: 133.8 thyroid gland: 78.4 KLF4 EZF, GKLF ENSG00000136826 Kruppel-like factor 4 (gut) 9 107484852-107490482 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002926 Supported Supported Nucleoplasm Renal cancer:3.93e-5 (favourable) Expressed in all Expressed in all esophagus: 129.0 KLF6 BCD1, COPEB, CPBP, GBF, PAC1, ST12, Zf9 ENSG00000067082 Kruppel-like factor 6 10 3775996-3785281 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB013529, HPA069585 Supported Approved Nucleus
Nucleoli fibrillar center
Vesicles
Cytosol Renal cancer:2.28e-4 (favourable) Expressed in all Expressed in all thyroid gland: 321.3 KLK2 ENSG00000167751 Kallikrein-related peptidase 2 19 50861568-50880567 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA000764 Supported Tissue enriched Tissue enriched 174 prostate: 850.1 testis: 4.8 KMT2A ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1A, TRX1 ENSG00000118058 Lysine (K)-specific methyltransferase 2A 11 118436490-118526832 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017794, CAB024270, HPA044910 Supported Supported Nucleoplasm
Cytosol Expressed in all Expressed in all parathyroid gland: 31.1 KMT2C HALR, KIAA1506, MLL3 ENSG00000055609 Lysine (K)-specific methyltransferase 2C 7 152134922-152436005 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA074736 Supported Nucleoplasm Renal cancer:8.01e-6 (favourable) Expressed in all Expressed in all skin: 25.8 KMT2D ALR, CAGL114, MLL2, MLL4, TNRC21 ENSG00000167548 Lysine (K)-specific methyltransferase 2D 12 49018975-49059774 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA035977 Approved Approved Nucleus
Plasma membrane
Cytosol Expressed in all Expressed in all parathyroid gland: 45.7 KRAS KRAS1, KRAS2 ENSG00000133703 Kirsten rat sarcoma viral oncogene homolog 12 25204789-25250936 Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA049830 Approved Renal cancer:2.75e-5 (favourable), Pancreatic cancer:3.59e-4 (unfavourable) Expressed in all Expressed in all rectum: 34.1 KTN1 CG1, KIAA0004 ENSG00000126777 Kinectin 1 (kinesin receptor) 14 55559072-55701526 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA003178, CAB015331, HPA017876 Supported Validated Endoplasmic reticulum Renal cancer:1.01e-6 (favourable), Head and neck cancer:6.83e-5 (unfavourable), Liver cancer:3.76e-4 (unfavourable) Expressed in all Expressed in all testis: 269.6 LASP1 Lasp-1, MLN50 ENSG00000002834 LIM and SH3 protein 1 17 38869859-38921770 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA012072, CAB022049 Supported Supported Plasma membrane
Focal adhesion sites
Cytosol Liver cancer:2.41e-4 (unfavourable), Endometrial cancer:4.57e-4 (unfavourable) Expressed in all Expressed in all small intestine: 185.0 LCK ENSG00000182866 LCK proto-oncogene, Src family tyrosine kinase 1 32251239-32286165 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level HPA003494, CAB003816 Supported Approved Golgi apparatus Endometrial cancer:2.96e-6 (favourable), Renal cancer:2.60e-5 (unfavourable), Melanoma:5.65e-5 (favourable), Head and neck cancer:2.91e-4 (favourable) Mixed Tissue enhanced appendix: 68.8;lymph node: 127.7;tonsil: 75.1 spleen: 55.2 LCP1 CP64, L-PLASTIN, LC64P, PLS2 ENSG00000136167 Lymphocyte cytosolic protein 1 (L-plastin) 13 46125920-46211871 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019493, CAB020673 Supported Approved Plasma membrane
Actin filaments
Cytosol Expressed in all Expressed in all lymph node: 622.1 LHFP MGC22429 ENSG00000183722 Lipoma HMGIC fusion partner 13 39342892-39603528 Cancer-related genes, Disease related genes, Predicted membrane proteins Evidence at protein level HPA058975 Approved Approved Nucleoli Renal cancer:1.20e-7 (unfavourable), Urothelial cancer:2.30e-4 (unfavourable) Expressed in all Mixed placenta: 195.0 LIFR CD118 ENSG00000113594 Leukemia inhibitory factor receptor alpha 5 38474963-38608354 Cancer-related genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA004478, CAB010252 Approved Approved Nuclear speckles
Golgi apparatus Renal cancer:1.40e-7 (favourable), Lung cancer:1.92e-4 (favourable) Mixed Mixed thyroid gland: 71.7 LMNA CMD1A, HGPS, LGMD1B, LMN1, LMNL1, PRO1 ENSG00000160789 Lamin A/C 1 156082573-156140089 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004022, HPA006660 Supported Expressed in all Expressed in all gallbladder: 344.5 LMO2 RBTN2, RBTNL1, RHOM2, TTG2 ENSG00000135363 LIM domain only 2 (rhombotin-like 1) 11 33858576-33892289 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB016258, HPA029285 Approved Approved Nucleoplasm
Cytosol Liver cancer:3.12e-4 (favourable) Expressed in all Mixed spleen: 26.2 LPP ENSG00000145012 LIM domain containing preferred translocation partner in lipoma 3 188153284-188890671 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA011133, HPA017342 Supported Validated Focal adhesion sites
Cytosol Expressed in all Expressed in all smooth muscle: 116.9 LRIG3 FLJ90440, KIAA3016 ENSG00000139263 Leucine-rich repeats and immunoglobulin-like domains 3 12 58872149-58920522 Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010773 Approved Approved Cytosol Expressed in all Tissue enhanced thyroid gland: 97.1 skin: 33.1 LSM14A C19orf13, DKFZP434D1335, FAM61A, RAP55, RAP55A ENSG00000257103 LSM14A mRNA processing body assembly factor 19 34172504-34229515 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA017961 Approved Supported Cytosol
Cytoplasmic bodies Expressed in all Mixed thyroid gland: 37.3 LYL1 bHLHa18 ENSG00000104903 Lymphoblastic leukemia associated hematopoiesis regulator 1 19 13099033-13103161 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA075004 Approved Golgi apparatus Renal cancer:3.89e-4 (unfavourable) Expressed in all Tissue enhanced bone marrow: 22.9;spleen: 21.2 appendix: 14.8 MAF c-MAF ENSG00000178573 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 16 79585843-79600714 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB010296, HPA028289 Approved Renal cancer:3.74e-4 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 147.2 small intestine: 93.1 MAFB KRML ENSG00000204103 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 20 40685848-40689240 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005653 Approved Approved Nucleus
Nucleoli Endometrial cancer:5.64e-4 (unfavourable) Expressed in all Tissue enriched 7 parathyroid gland: 677.4 spleen: 103.7 MALT1 MLT, PCASP1 ENSG00000172175 MALT1 paracaspase 18 58671386-58754477 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004494, HPA048432 Supported Supported Nucleoli
Cytosol Expressed in all Expressed in all lymph node: 34.4 MAML2 KIAA1819, MAM3 ENSG00000184384 Mastermind-like transcriptional coactivator 2 11 95976598-96343180 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA035223 Approved Supported Nucleoplasm
Nuclear bodies
Cytosol Renal cancer:1.90e-4 (favourable), Pancreatic cancer:3.89e-4 (unfavourable) Expressed in all Mixed placenta: 17.4 MAP2K1 MAPKK1, MEK1, PRKMK1 ENSG00000169032 Mitogen-activated protein kinase kinase 1 15 66386817-66492312 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB003834, HPA026430 Approved Validated Plasma membrane
Cytosol Glioma:2.68e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 144.8 MAP2K2 MEK2, PRKMK2 ENSG00000126934 Mitogen-activated protein kinase kinase 2 19 4090321-4124129 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB003835, HPA051993 Supported Validated Cytosol Stomach cancer:5.43e-5 (favourable), Cervical cancer:3.72e-4 (favourable), Head and neck cancer:7.98e-4 (favourable) Expressed in all Expressed in all duodenum: 138.7 MAP2K4 JNKK1, MEK4, MKK4, PRKMK4, SERK1 ENSG00000065559 Mitogen-activated protein kinase kinase 4 17 12020824-12143830 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB007751, HPA060074 Supported Approved Nucleoplasm
Cell Junctions Expressed in all Expressed in all cerebral cortex: 64.2 MAP3K1 MAPKKK1, MEKK, MEKK1 ENSG00000095015 Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 5 56815574-56896152 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level CAB004500, HPA046509 Approved Approved Cytosol Expressed in all Mixed spleen: 28.7 MAP3K13 LZK, MEKK13 ENSG00000073803 Mitogen-activated protein kinase kinase kinase 13 3 185282941-185489097 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA016497, HPA036691, HPA036692 Uncertain Approved Nucleoplasm
Microtubule organizing center
Cytosol Endometrial cancer:1.28e-5 (unfavourable), Pancreatic cancer:7.27e-5 (unfavourable), Ovarian cancer:1.11e-4 (favourable) Expressed in all Expressed in all epididymis: 68.4 MAX bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 ENSG00000125952 MYC associated factor X 14 65006174-65102695 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000328, HPA003474 Supported Supported Nucleoplasm
Golgi apparatus
Vesicles Thyroid cancer:2.12e-4 (favourable), Renal cancer:5.57e-4 (unfavourable) Expressed in all Expressed in all spleen: 80.2 MDM2 HDM2, MGC5370 ENSG00000135679 MDM2 proto-oncogene, E3 ubiquitin protein ligase 12 68808172-68850686 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB000086, CAB016303 Supported Supported Nucleus Endometrial cancer:4.51e-7 (favourable), Cervical cancer:3.23e-4 (favourable) Expressed in all Expressed in all rectum: 44.3 MDM4 HDMX, MDMX ENSG00000198625 MDM4, p53 regulator 1 204516379-204558120 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA018919, HPA048821 Approved Supported Nucleus Renal cancer:7.06e-6 (unfavourable), Urothelial cancer:2.49e-4 (favourable), Prostate cancer:9.87e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 37.5 MECOM EVI1, MDS1, MDS1-EVI1, PRDM3 ENSG00000085276 MDS1 and EVI1 complex locus 3 169083499-169663618 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA046537 Supported Supported Nuclear speckles Pancreatic cancer:2.59e-4 (unfavourable) Mixed Mixed stomach: 66.8 MED12 CAGH45, FGS1, HOPA, KIAA0192, OKS, OPA1, TNRC11, TRAP230 ENSG00000184634 Mediator complex subunit 12 X 71118556-71142454 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA003184, HPA003185 Supported Approved Nucleoplasm Expressed in all Expressed in all spleen: 27.1 MEN1 ENSG00000133895 Multiple endocrine neoplasia I 11 64803510-64811294 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA030342 Uncertain Supported Nucleoplasm
Cytosol Stomach cancer:6.31e-5 (favourable), Liver cancer:1.08e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 22.2 MET DFNB97, HGFR, RCCP2 ENSG00000105976 MET proto-oncogene, receptor tyrosine kinase 7 116672390-116798386 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB005282, CAB018577, HPA055607 Uncertain Supported Plasma membrane
Cytosol Pancreatic cancer:1.21e-7 (unfavourable), Head and neck cancer:6.75e-4 (unfavourable) Expressed in all Mixed placenta: 38.7 MITF bHLHe32, MI, WS2, WS2A ENSG00000187098 Microphthalmia-associated transcription factor 3 69739435-69968337 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB002578, HPA003259 Supported Renal cancer:8.35e-10 (favourable) Group enriched Tissue enhanced cervix, uterine: 80.4;endometrium: 78.8 smooth muscle: 68.6 MKL1 BSAC, KIAA1438, MAL, MRTF-A ENSG00000196588 Megakaryoblastic leukemia (translocation) 1 22 40410281-40636702 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA030782 Approved Supported Nucleoplasm
Cytosol Renal cancer:1.58e-7 (unfavourable) Expressed in all Expressed in all bone marrow: 51.3 MLF1 ENSG00000178053 Myeloid leukemia factor 1 3 158571163-158607252 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA069479 Approved Nucleoplasm
Cytosol Endometrial cancer:2.15e-5 (unfavourable), Stomach cancer:5.54e-4 (unfavourable) Mixed Tissue enriched 6 testis: 667.3 heart muscle: 104.2 MLH1 COCA2, FCC2, HNPCC, HNPCC2 ENSG00000076242 MutL homolog 1 3 36993332-37050918 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013294, HPA052707, HPA060714, CAB070868 Supported Validated Nucleoplasm Liver cancer:8.24e-5 (unfavourable) Expressed in all Expressed in all testis: 59.7 MLLT1 ENL, LTG19, YEATS1 ENSG00000130382 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 19 6210379-6279948 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA031166 Approved Supported Nucleoplasm Head and neck cancer:6.03e-5 (favourable) Expressed in all Expressed in all placenta: 61.2 MLLT10 AF10 ENSG00000078403 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 10 21524675-21743630 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA005747 Supported Supported Nucleoplasm Head and neck cancer:8.75e-4 (favourable) Expressed in all Expressed in all testis: 176.8 MLLT11 AF1Q ENSG00000213190 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 1 151057758-151068497 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA000540 Uncertain Supported Nucleoplasm
Cytosol Renal cancer:4.25e-12 (unfavourable), Endometrial cancer:4.26e-5 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 122.9 parathyroid gland: 26.9 MLLT3 AF-9, AF9, YEATS3 ENSG00000171843 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 9 20341665-20622543 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA001824 Approved Approved Nucleoplasm
Cytosol Renal cancer:1.84e-4 (favourable) Expressed in all Mixed thyroid gland: 40.4 MLLT4 AF-6, AF6 ENSG00000130396 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 6 167826922-167972023 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB013496, HPA030212, HPA030213, HPA030214, HPA030215, HPA049868 Approved Validated Nucleoplasm
Plasma membrane
Cell Junctions Breast cancer:7.43e-5 (unfavourable) Expressed in all Expressed in all esophagus: 111.1 MLLT6 AF17, FLJ23480 ENSG00000275023 Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 17 38705542-38729803 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA004021 Approved Approved Nucleus Head and neck cancer:3.98e-4 (favourable), Breast cancer:4.18e-4 (favourable), Pancreatic cancer:7.41e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 35.2 MN1 MGCR, MGCR1, MGCR1-PEN ENSG00000169184 Meningioma (disrupted in balanced translocation) 1 22 27748277-27801498 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA003072 Approved Approved Nucleoplasm Mixed Tissue enhanced skeletal muscle: 22.0 cerebral cortex: 6.4 MNX1 HB9, HLXB9, HOXHB9, SCRA1 ENSG00000130675 Motor neuron and pancreas homeobox 1 7 156994051-157010651 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA071717 Approved Nucleus
Nucleoli
Cytosol Mixed Tissue enhanced duodenum: 7.5;small intestine: 6.8 colon: 3.8 MPL CD110, TPOR ENSG00000117400 MPL proto-oncogene, thrombopoietin receptor 1 43337807-43352772 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA007619 Uncertain Plasma membrane Not detected Tissue enhanced testis: 1.8 ovary: 1.3 MSH2 COCA1, HNPCC, HNPCC1 ENSG00000095002 MutS homolog 2 2 47402969-47562311 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009572, CAB070867 Supported Approved Nucleoplasm
Vesicles Liver cancer:1.72e-9 (unfavourable), Endometrial cancer:4.44e-4 (unfavourable), Pancreatic cancer:4.63e-4 (unfavourable) Expressed in all Expressed in all testis: 32.6 MSH6 GTBP ENSG00000116062 MutS homolog 6 2 47695530-47810101 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009091, HPA028376, HPA028446 Supported Supported Nucleoplasm
Golgi apparatus
Vesicles Renal cancer:1.06e-7 (unfavourable), Endometrial cancer:1.34e-4 (unfavourable), Liver cancer:7.86e-4 (unfavourable) Expressed in all Expressed in all ovary: 74.4 MSI2 ENSG00000153944 Musashi RNA-binding protein 2 17 57255851-57684685 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB022300 Approved Supported Cytosol Renal cancer:9.22e-8 (favourable), Stomach cancer:2.00e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 117.6 MSN ENSG00000147065 Moesin X 65588377-65741931 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA000263, CAB010898, HPA011135, HPA011227, CAB047336, CAB047338 Supported Validated Plasma membrane Renal cancer:1.60e-5 (unfavourable) Expressed in all Expressed in all lung: 421.4 MTCP1 P13MTCP1, p8MTCP1 ENSG00000214827 Mature T-cell proliferation 1 X 155061622-155147937 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA032040 Approved Nucleoplasm
Plasma membrane Renal cancer:4.52e-8 (unfavourable) Mixed Mixed testis: 8.7 MUC1 ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM ENSG00000185499 Mucin 1, cell surface associated 1 155185824-155192916 Cancer-related genes, CD markers, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000036, CAB001986, HPA004179, HPA007235, HPA008855 Supported Validated Vesicles
Plasma membrane Pancreatic cancer:4.60e-4 (unfavourable) Expressed in all Tissue enhanced lung: 447.5;stomach: 650.2 cervix, uterine: 286.5 MUTYH MYH ENSG00000132781 MutY DNA glycosylase 1 45329163-45340470 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA008732 Uncertain Supported Nucleus Liver cancer:4.76e-8 (unfavourable), Renal cancer:7.25e-5 (unfavourable) Expressed in all Mixed thyroid gland: 10.7 MYB c-myb ENSG00000118513 V-myb avian myeloblastosis viral oncogene homolog 6 135181315-135219173 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017704 Approved Approved Nucleus
Plasma membrane Prostate cancer:9.65e-4 (favourable), Stomach cancer:9.87e-4 (favourable) Tissue enhanced Tissue enhanced breast: 25.9;rectum: 29.6 colon: 25.7 MYC bHLHe39, c-Myc, MYCC ENSG00000136997 V-myc avian myelocytomatosis viral oncogene homolog 8 127735434-127741434 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000084, CAB010307, HPA055893, HPA066556 Supported Validated Nucleoplasm Renal cancer:5.49e-8 (unfavourable), Urothelial cancer:4.96e-5 (unfavourable), Ovarian cancer:7.52e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 144.4 MYCL bHLHe38, LMYC, MYCL1 ENSG00000116990 V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 1 39895426-39902256 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA063132 Supported Nucleus Lung cancer:4.49e-4 (favourable) Expressed in all Tissue enhanced skin: 41.7 urinary bladder: 24.6 MYCN bHLHe37, MYCNOT, N-myc, NMYC ENSG00000134323 V-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2 15940564-15947007 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA057420 Approved Nucleus
Nucleoli Tissue enhanced Tissue enhanced placenta: 9.6 cerebral cortex: 5.3 MYD88 ENSG00000172936 Myeloid differentiation primary response 88 3 38138478-38143022 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009104 Approved Supported Vesicles
Mitochondria
Cytosol Breast cancer:8.45e-4 (favourable) Expressed in all Mixed appendix: 57.6 MYH11 SMHC, SMMHC ENSG00000133392 Myosin, heavy chain 11, smooth muscle 16 15703135-15857033 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB002302, HPA014539, HPA015310 Supported Approved Plasma membrane
Cytosol Liver cancer:1.10e-5 (favourable) Tissue enhanced Tissue enhanced seminal vesicle: 1365.9;smooth muscle: 1008.5 prostate: 841.6 MYH9 DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA ENSG00000100345 Myosin, heavy chain 9, non-muscle 22 36281281-36388018 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA001644, CAB015386 Supported Approved Plasma membrane
Actin filaments
Cytosol Expressed in all Expressed in all spleen: 313.7 MYO5A GS1, MYH12, MYO5, MYR12 ENSG00000197535 Myosin VA 15 52307283-52529050 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA001356 Approved Approved Focal adhesion sites
Microtubule organizing center Urothelial cancer:4.22e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 94.6 MYOD1 bHLHc1, MYF3, MYOD, PUM ENSG00000129152 Myogenic differentiation 1 11 17719568-17722131 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA051362 Supported Nucleoplasm
Nuclear bodies
Cytosol Tissue enhanced Tissue enriched 12 skeletal muscle: 9.0 prostate: 0.7 NAB2 MADER ENSG00000166886 NGFI-A binding protein 2 (EGR1 binding protein 2) 12 57088894-57095476 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004510, HPA027464 Approved Approved Nucleus
Cytosol Renal cancer:9.38e-6 (unfavourable), Breast cancer:7.41e-4 (favourable) Expressed in all Expressed in all ovary: 39.3 NACA NACA1 ENSG00000196531 Nascent polypeptide-associated complex alpha subunit 12 56712428-56731628 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA073152, HPA073648 Approved Cytosol Renal cancer:4.58e-11 (unfavourable) Expressed in all Expressed in all ovary: 2544.0 NBN AT-V1, AT-V2, ATV, NBS, NBS1 ENSG00000104320 Nibrin 8 89933336-90003228 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA001429, CAB003836 Supported Approved Nucleoplasm
Golgi apparatus Lung cancer:5.46e-5 (unfavourable), Pancreatic cancer:4.20e-4 (unfavourable) Expressed in all Expressed in all appendix: 38.1 NCKIPSD AF3P21, DIP1, ORF1, SPIN90, WASLBP, WISH ENSG00000213672 NCK interacting protein with SH3 domain 3 48673844-48686364 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB019267, HPA050005 Validated Plasma membrane
Cytosol Renal cancer:1.20e-5 (favourable), Liver cancer:8.57e-4 (unfavourable) Expressed in all Tissue enriched 9 parathyroid gland: 300.2 cerebral cortex: 35.1 NCOA1 bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1 ENSG00000084676 Nuclear receptor coactivator 1 2 24491914-24770702 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB019402, HPA070213, HPA070520 Supported Validated Nucleoplasm
Plasma membrane
Cytosol Expressed in all Expressed in all parathyroid gland: 58.0 NCOA2 bHLHe75, GRIP1, KAT13C, NCoA-2, TIF2 ENSG00000140396 Nuclear receptor coactivator 2 8 70109762-70403805 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA060243 Supported Nucleoplasm
Nuclear bodies Renal cancer:5.08e-4 (favourable) Expressed in all Expressed in all epididymis: 35.4 NCOA4 ARA70, DKFZp762E1112, ELE1, PTC3, RFG ENSG00000266412 Nuclear receptor coactivator 4 10 46005088-46030714 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA051260, HPA065208 Uncertain Approved Nucleoli
Golgi apparatus
Cytosol Renal cancer:8.04e-6 (favourable), Glioma:2.88e-4 (favourable) Expressed in all Expressed in all duodenum: 253.9 NCOR1 hCIT529I10, hN-CoR, KIAA1047, MGC104216, N-CoR, PPP1R109, TRAC1 ENSG00000141027 Nuclear receptor corepressor 1 17 16029157-16218185 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043246, HPA050288, HPA051168, CAB072830 Supported Validated Nucleoplasm
Cytosol Renal cancer:7.92e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 84.0 NDRG1 CAP43, DRG1, NDR1, RTP, TDD5 ENSG00000104419 N-myc downstream regulated 1 8 133237171-133302022 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006881 Approved Supported Microtubules
Cytosol Liver cancer:1.47e-4 (unfavourable), Renal cancer:4.13e-4 (unfavourable), Glioma:7.24e-4 (unfavourable) Expressed in all Expressed in all prostate: 487.4 NF1 ENSG00000196712 Neurofibromin 1 17 31094927-31382116 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA045502 Uncertain Approved Mitochondria Expressed in all Expressed in all parathyroid gland: 31.9 NF2 merlin ENSG00000186575 Neurofibromin 2 (merlin) 22 29603556-29698598 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA003097, CAB005385 Supported Validated Nucleus
Plasma membrane
Cytosol Renal cancer:2.89e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 57.6 NFATC2 NF-ATP, NFAT1, NFATp ENSG00000101096 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 20 51386957-51562831 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA008789, CAB018567, HPA024369 Supported Supported Nucleoplasm
Cytosol Renal cancer:1.57e-4 (unfavourable) Expressed in all Expressed in all gallbladder: 26.8 NFE2L2 NRF2 ENSG00000116044 Nuclear factor, erythroid 2-like 2 2 177227595-177392697 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002990, CAB020317, HPA043438 Supported Approved Nucleus
Plasma membrane
Cytosol Renal cancer:2.26e-4 (favourable) Expressed in all Expressed in all esophagus: 267.9 NFIB NFI-RED, NFIB2, NFIB3 ENSG00000147862 Nuclear factor I/B 9 14081843-14398983 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003956 Supported Supported Nucleus
Nucleoli fibrillar center Renal cancer:3.53e-4 (favourable) Expressed in all Mixed breast: 44.4 NFKB2 LYT-10, NF-kB2, p105, p52 ENSG00000077150 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 10 102394110-102402529 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA008422, CAB022098, HPA023900 Supported Approved Nucleoplasm
Cytosol Renal cancer:6.69e-12 (unfavourable), Melanoma:8.45e-5 (favourable), Colorectal cancer:3.86e-4 (unfavourable) Expressed in all Expressed in all appendix: 72.8 NFKBIE IKBE ENSG00000146232 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 6 44258166-44265788 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002692, HPA005941, CAB010272 Supported Supported Nucleus
Nucleoli fibrillar center
Cytosol Renal cancer:1.37e-6 (unfavourable), Breast cancer:1.72e-5 (favourable), Liver cancer:3.50e-4 (unfavourable), Urothelial cancer:8.07e-4 (favourable) Expressed in all Mixed appendix: 26.8 NIN ENSG00000100503 Ninein (GSK3B interacting protein) 14 50719763-50831121 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA005939, HPA070691 Supported Validated Nucleus
Nucleoli
Centrosome Expressed in all Mixed lymph node: 48.1 NKX2-1 BCH, NKX2A, TITF1, TTF-1, TTF1 ENSG00000136352 NK2 homeobox 1 14 36516392-36521149 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000078, CAB053633, HPA074316 Supported Uncertain Golgi apparatus
Vesicles Group enriched Group enriched 174 lung: 102.0;thyroid gland: 103.6 stomach: 0.5 NONO NMT55, NRB54, P54, P54NRB, PPP1R114 ENSG00000147140 Non-POU domain containing, octamer-binding X 71283192-71301168 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB022069, HPA054094, HPA054559 Supported Validated Nucleoplasm Endometrial cancer:9.29e-4 (unfavourable) Expressed in all Expressed in all ovary: 245.1 NOTCH1 TAN1 ENSG00000148400 Notch 1 9 136494444-136545862 Cancer-related genes, Disease related genes, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB008112, CAB022466, HPA067168 Supported Approved Nucleoplasm Renal cancer:5.45e-4 (unfavourable) Expressed in all Expressed in all skin: 24.0 NOTCH2 ENSG00000134250 Notch 2 1 119911553-120069626 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA046392, HPA048743 Uncertain Supported Nucleoplasm
Plasma membrane Ovarian cancer:5.24e-4 (unfavourable), Pancreatic cancer:9.48e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 46.5 NPM1 B23, NPM ENSG00000181163 Nucleophosmin (nucleolar phosphoprotein B23, numatrin) 5 171387116-171411137 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA011384, CAB012983 Supported Validated Nucleus
Nucleoli Renal cancer:2.89e-6 (unfavourable), Liver cancer:4.82e-6 (unfavourable), Head and neck cancer:7.48e-4 (unfavourable) Expressed in all Expressed in all ovary: 1797.0 NR4A3 CHN, CSMF, MINOR, NOR1 ENSG00000119508 Nuclear receptor subfamily 4, group A, member 3 9 99821855-99866891 Cancer-related genes, Disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043360 Uncertain Breast cancer:5.97e-4 (favourable) Mixed Tissue enhanced adrenal gland: 89.5 urinary bladder: 43.5 NRAS N-ras ENSG00000213281 Neuroblastoma RAS viral (v-ras) oncogene homolog 1 114704469-114716894 Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB010157, HPA049830 Uncertain Liver cancer:3.03e-7 (unfavourable), Pancreatic cancer:1.36e-4 (unfavourable), Renal cancer:7.87e-4 (unfavourable) Expressed in all Expressed in all placenta: 39.1 NRG1 GGF, HGL, HRG, NDF, NRG1-IT2 ENSG00000157168 Neuregulin 1 8 31639386-32767959 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA010964 Uncertain Approved Nucleoplasm Tissue enhanced Mixed thyroid gland: 19.9 NSD1 ARA267, FLJ22263, KMT3B, STO ENSG00000165671 Nuclear receptor binding SET domain protein 1 5 177133025-177300215 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA048431, HPA070333 Supported Nucleus
Plasma membrane Expressed in all Expressed in all testis: 43.2 NT5C2 cN-II, GMP, NT5B, PNT5, SPG65 ENSG00000076685 5'-nucleotidase, cytosolic II 10 103088017-103193306 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA003751 Approved Expressed in all Expressed in all thyroid gland: 118.9 NTRK1 MTC, TRK, TRKA ENSG00000198400 Neurotrophic tyrosine kinase, receptor, type 1 1 156815640-156881850 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level CAB004606, HPA035799, HPA076570 Approved Uncertain Vesicles
Cytosol Tissue enhanced Tissue enriched 6 adrenal gland: 9.6 testis: 1.6 NTRK3 TRKC ENSG00000140538 Neurotrophic tyrosine kinase, receptor, type 3 15 87859751-88256768 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB009233, HPA027484, HPA048065 Supported Supported Nuclear membrane
Nucleoli Tissue enhanced Tissue enhanced cerebral cortex: 39.7 testis: 15.2 NUMA1 ENSG00000137497 Nuclear mitotic apparatus protein 1 11 72002864-72080693 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019841, HPA019859, HPA029912 Supported Validated Nucleoplasm Renal cancer:7.92e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 243.4 NUP214 CAIN, CAN, D9S46E, N214 ENSG00000126883 Nucleoporin 214kDa 9 131125561-131234670 Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA048789 Supported Nucleus
Vesicles
Focal adhesion sites Renal cancer:2.39e-5 (favourable) Expressed in all Expressed in all testis: 122.9 NUP98 NUP96 ENSG00000110713 Nucleoporin 98kDa 11 3671083-3797792 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA074810 Supported Nucleoplasm
Vesicles Expressed in all Expressed in all testis: 150.1 NUTM1 C15orf55, DKFZp434O192, FAM22H, NUT ENSG00000184507 NUT midline carcinoma, family member 1 15 34343315-34357737 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA040421 Approved Not detected Tissue enriched 78 testis: 22.5 duodenum,skin: 0.2 NUTM2A FAM22A ENSG00000184923 NUT family member 2A 10 87225448-87236908 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA064635 Uncertain Nuclear bodies Not detected Mixed skin: 1.9 NUTM2B bA119F19.1, FAM22B ENSG00000188199 NUT family member 2B 10 79703227-79714681 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA064635 Uncertain Nuclear bodies Not detected Mixed testis: 2.2 OLIG2 BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17 ENSG00000205927 Oligodendrocyte lineage transcription factor 2 21 33025845-33029196 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003254, CAB019381 Supported Uncertain Nucleoplasm
Plasma membrane Tissue enriched Tissue enriched 239 cerebral cortex: 91.2 duodenum: 0.3 OMD osteoadherin, SLRR2C ENSG00000127083 Osteomodulin 9 92414245-92424461 Cancer-related genes, Predicted secreted proteins Evidence at protein level HPA005731 Approved Mixed Mixed cervix, uterine: 36.2 P2RY8 P2Y8 ENSG00000182162 Purinergic receptor P2Y, G-protein coupled, 8 X 1462572-1537107 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA003631 Supported Head and neck cancer:7.80e-5 (favourable), Liver cancer:1.73e-4 (favourable), Pancreatic cancer:6.54e-4 (favourable) Expressed in all Tissue enhanced lymph node: 43.1 tonsil: 29.0 PAFAH1B2 ENSG00000168092 Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 11 117144267-117176894 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA051836 Approved Supported Nucleoli
Plasma membrane
Cytosol Pancreatic cancer:7.79e-5 (unfavourable), Lung cancer:3.07e-4 (unfavourable), Ovarian cancer:4.25e-4 (favourable), Liver cancer:9.44e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 68.4 PALB2 FANCN, FLJ21816 ENSG00000083093 Partner and localizer of BRCA2 16 23603160-23641310 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB014895, HPA057000 Approved Supported Nucleoplasm Pancreatic cancer:2.35e-5 (unfavourable), Colorectal cancer:2.83e-5 (favourable) Expressed in all Mixed testis: 14.4 PATZ1 dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG ENSG00000100105 POZ (BTB) and AT hook containing zinc finger 1 22 31325804-31346232 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA047893, HPA048315 Approved Supported Nucleoplasm Renal cancer:8.54e-8 (favourable), Urothelial cancer:7.79e-6 (favourable), Glioma:6.53e-5 (favourable), Lung cancer:8.71e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 39.8 PAX3 HUP2, WS1 ENSG00000135903 Paired box 3 2 222199888-222298996 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA063659, HPA069000 Uncertain Supported Nucleoplasm Tissue enriched Group enriched 9 breast: 1.2;skeletal muscle: 1.1;skin: 3.2;testis: 2.4 prostate: 0.2 PAX5 BSAP ENSG00000196092 Paired box 5 9 36833275-37034185 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB026269, CAB026869, HPA056394, HPA068498 Supported Approved Nucleoplasm
Vesicles
Cytosol Mixed Tissue enhanced lymph node: 49.1;spleen: 26.7;tonsil: 35.2 appendix: 20.2 PAX8 ENSG00000125618 Paired box 8 2 113215997-113278950 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030062, HPA064554 Validated Nucleoplasm Endometrial cancer:1.75e-5 (unfavourable) Group enriched Tissue enriched 10 thyroid gland: 642.7 kidney: 65.0 PBRM1 BAF180, PB1 ENSG00000163939 Polybromo 1 3 52545352-52685917 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA015629, HPA059373 Uncertain Supported Nucleoplasm Expressed in all Expressed in all thyroid gland: 44.5 PBX1 ENSG00000185630 Pre-B-cell leukemia homeobox 1 1 164555584-164899296 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003505, HPA003881, CAB018768 Supported Validated Nucleoplasm Mixed Expressed in all endometrium: 246.5 PCM1 PTC4 ENSG00000078674 Pericentriolar material 1 8 17922840-18029944 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA023370, HPA023374, CAB058695 Supported Validated Nuclear membrane
Centrosome
Cytosol Expressed in all Expressed in all testis: 275.8 PCSK7 LPC, PC7, PC8, SPC7 ENSG00000160613 Proprotein convertase subtilisin/kexin type 7 11 117204337-117232525 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA043181, HPA052957 Uncertain Nucleus
Nuclear membrane
Nucleoli Expressed in all Expressed in all smooth muscle: 305.0 PDCD1LG2 B7-DC, bA574F11.2, Btdc, CD273, PD-L2, PDL2 ENSG00000197646 Programmed cell death 1 ligand 2 9 5510570-5571254 Cancer-related genes, CD markers, Predicted membrane proteins Evidence at protein level HPA013411 Approved Approved Cytosol Renal cancer:1.15e-4 (unfavourable) Mixed Tissue enhanced spleen: 21.8 lymph node: 12.2 PDE4DIP CMYA2, KIAA0454, KIAA0477, MMGL ENSG00000178104 Phosphodiesterase 4D interacting protein 1 148808181-149048286 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA008162, HPA012678 Uncertain Supported Golgi apparatus Expressed in all Expressed in all skeletal muscle: 769.6 PDGFB SIS, SSV ENSG00000100311 Platelet-derived growth factor beta polypeptide 22 39223359-39244751 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB011604, HPA011972, CAB018341 Supported Approved Vesicles Lung cancer:3.67e-5 (unfavourable) Expressed in all Tissue enhanced placenta: 59.5 lung: 28.7 PDGFRA CD140a, GAS9, PDGFR2 ENSG00000134853 Platelet-derived growth factor receptor, alpha polypeptide 4 54229097-54298247 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level HPA004947, CAB018143 Supported Supported Nucleus
Plasma membrane
Cell Junctions Renal cancer:9.79e-6 (unfavourable), Head and neck cancer:9.33e-4 (favourable) Expressed in all Expressed in all ovary: 222.0 PDGFRB CD140b, JTK12, PDGFR, PDGFR1 ENSG00000113721 Platelet-derived growth factor receptor, beta polypeptide 5 150113837-150155872 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB003842, CAB018144, HPA028499 Approved Approved Vesicles
Cytosol Renal cancer:5.87e-8 (unfavourable), Urothelial cancer:8.11e-4 (unfavourable) Expressed in all Mixed gallbladder: 194.6 PER1 PER, RIGUI ENSG00000179094 Period circadian clock 1 17 8140472-8156506 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA047947, HPA067064 Supported Nucleoplasm
Cytosol Stomach cancer:1.94e-4 (unfavourable), Liver cancer:2.56e-4 (favourable), Cervical cancer:3.89e-4 (favourable) Expressed in all Expressed in all thyroid gland: 70.1 PHF6 BFLS, BORJ, CENP-31, KIAA1823, MGC14797 ENSG00000156531 PHD finger protein 6 X 134373253-134428791 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA001023 Supported Validated Nucleus
Nucleoli Liver cancer:3.38e-4 (unfavourable), Pancreatic cancer:9.96e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 41.2 PHOX2B NBPhox, Phox2b, PMX2B ENSG00000109132 Paired-like homeobox 2b 4 41744082-41748970 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA074325 Supported Nucleoplasm Not detected Tissue enriched 8 adrenal gland: 10.4 small intestine: 1.2 PICALM CALM, CLTH ENSG00000073921 Phosphatidylinositol binding clathrin assembly protein 11 85957684-86069882 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA019053, HPA019061 Supported Supported Vesicles Renal cancer:2.02e-6 (favourable), Pancreatic cancer:6.61e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 291.7 PIK3CA PI3K ENSG00000121879 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3 179148114-179240093 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA009985, CAB017804 Approved Approved Cytosol Expressed in all Mixed parathyroid gland: 23.9 PIK3R1 GRB1, p85, p85-ALPHA ENSG00000145675 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5 68215720-68301821 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA001216, CAB004268 Approved Approved Cytosol Liver cancer:8.09e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 133.3 PIM1 PIM ENSG00000137193 Pim-1 proto-oncogene, serine/threonine kinase 6 37170203-37175426 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA003941, CAB017040 Uncertain Supported Nucleoli
Cytosol Endometrial cancer:9.73e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 134.1 PLAG1 ZNF912 ENSG00000181690 Pleiomorphic adenoma gene 1 8 56160904-56211324 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA072290 Approved Nuclear speckles Mixed Mixed ovary: 5.9 PLCG1 NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 ENSG00000124181 Phospholipase C, gamma 1 20 41136960-41196801 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB004277, HPA036681, HPA036682 Approved Supported Cytosol Pancreatic cancer:4.72e-4 (favourable) Expressed in all Expressed in all endometrium: 47.4 PML MYL, RNF71, TRIM19 ENSG00000140464 Promyelocytic leukemia 15 73994673-74047812 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA008312, CAB010194, CAB016304 Supported Validated Nuclear bodies Renal cancer:6.27e-8 (unfavourable), Breast cancer:3.24e-4 (favourable), Pancreatic cancer:3.29e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 45.0 PMS1 MLH2, PMSL1 ENSG00000064933 PMS1 homolog 1, mismatch repair system component 2 189784085-189877629 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB010233, HPA031013 Approved Supported Nucleoplasm
Nuclear bodies Renal cancer:1.86e-6 (unfavourable), Liver cancer:2.38e-6 (unfavourable), Urothelial cancer:3.73e-4 (favourable) Expressed in all Expressed in all testis: 84.8 PMS2 HNPCC4, H_DJ0042M02.9, MLH4, PMSL2 ENSG00000122512 PMS1 homolog 2, mismatch repair system component 7 5973239-6009125 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB010235, HPA044400, HPA066490, HPA070310 Approved Validated Nucleoplasm
Cytosol Renal cancer:1.23e-5 (favourable) Expressed in all Mixed cerebral cortex: 20.0 POLE POLE1 ENSG00000177084 Polymerase (DNA directed), epsilon, catalytic subunit 12 132623753-132687365 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA058210, HPA067385 Validated Nucleus
Plasma membrane Renal cancer:3.19e-8 (unfavourable), Melanoma:1.44e-4 (unfavourable) Expressed in all Expressed in all testis: 22.0 POT1 DKFZp586D211, hPot1 ENSG00000128513 Protection of telomeres 1 7 124822386-124929983 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA068538 Supported Nucleus Expressed in all Mixed thyroid gland: 21.5 POU2AF1 OBF1 ENSG00000110777 POU class 2 associating factor 1 11 111352252-111455630 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB011193 Approved Cervical cancer:1.63e-4 (favourable), Breast cancer:1.68e-4 (favourable), Head and neck cancer:3.59e-4 (favourable) Mixed Tissue enhanced lymph node: 103.0;tonsil: 97.6 appendix: 57.6 POU5F1 MGC22487, OCT3, Oct4, OTF3 ENSG00000204531 POU class 5 homeobox 1 6 31164337-31180731 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB025600, CAB026380, HPA058267 Approved Supported Nucleoplasm
Cytosol Urothelial cancer:2.04e-5 (favourable) Tissue enriched Mixed small intestine: 5.8 PPARG NR1C3, PPARG1, PPARG2, PPARgamma ENSG00000132170 Peroxisome proliferator-activated receptor gamma 3 12287368-12434356 Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004282, HPA051239, HPA063663 Approved Validated Nucleus
Vesicles Renal cancer:1.59e-8 (favourable), Liver cancer:3.41e-5 (unfavourable), Urothelial cancer:5.52e-5 (favourable) Expressed in all Tissue enhanced adipose tissue: 172.8 placenta: 58.6 PPFIBP1 hSGT2, hSgt2p, L2, SGT2 ENSG00000110841 PTPRF interacting protein, binding protein 1 (liprin beta 1) 12 27523431-27695564 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA001924 Uncertain Approved Plasma membrane
Cytosol Renal cancer:5.11e-7 (favourable), Pancreatic cancer:2.56e-4 (unfavourable), Lung cancer:5.11e-4 (unfavourable), Endometrial cancer:6.29e-4 (unfavourable) Expressed in all Expressed in all ovary: 106.2 PPP2R1A PP2A-Aalpha, PR65A ENSG00000105568 Protein phosphatase 2, regulatory subunit A, alpha 19 52190039-52229533 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB018599 Approved Cytosol Renal cancer:1.20e-4 (favourable), Liver cancer:1.76e-4 (unfavourable), Lung cancer:2.50e-4 (unfavourable) Expressed in all Expressed in all fallopian tube: 205.2 PPP6C PP6 ENSG00000119414 Protein phosphatase 6, catalytic subunit 9 125146573-125189939 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA050940 Uncertain Renal cancer:4.50e-6 (favourable) Expressed in all Expressed in all thyroid gland: 52.4 PRCC RCCP1 ENSG00000143294 Papillary renal cell carcinoma (translocation-associated) 1 156750610-156800817 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB017151, HPA019463, HPA019481 Supported Validated Nuclear speckles Renal cancer:8.99e-15 (unfavourable), Thyroid cancer:3.72e-4 (unfavourable), Endometrial cancer:5.55e-4 (unfavourable), Liver cancer:8.63e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 54.7 PRDM1 BLIMP1, PRDI-BF1 ENSG00000057657 PR domain containing 1, with ZNF domain 6 106086320-106109939 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030033 Approved Approved Nucleus
Nucleoli Renal cancer:9.81e-5 (unfavourable) Expressed in all Tissue enhanced esophagus: 61.3 endometrium: 30.1 PRDM16 KIAA1675, MEL1, MGC166915, PFM13 ENSG00000142611 PR domain containing 16 1 3069168-3438621 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA050343, HPA060467 Validated Nucleoplasm Thyroid cancer:4.70e-5 (unfavourable) Mixed Mixed duodenum: 7.8 PRF1 HPLH2, P1, PFP ENSG00000180644 Perforin 1 (pore forming protein) 10 70597348-70602775 Cancer-related genes, Disease related genes, Predicted secreted proteins Evidence at protein level CAB002436, HPA037940 Approved Approved Cytosol Renal cancer:1.08e-5 (unfavourable), Endometrial cancer:2.09e-4 (favourable), Head and neck cancer:3.54e-4 (favourable) Expressed in all Tissue enhanced spleen: 54.5 lymph node: 21.2 PRKAR1A CNC1, PRKAR1, TSE1 ENSG00000108946 Protein kinase, cAMP-dependent, regulatory, type I, alpha 17 68511780-68551319 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB019378, HPA049979 Approved Approved Cytosol Expressed in all Expressed in all parathyroid gland: 555.0 PRRX1 PHOX1, PMX1 ENSG00000116132 Paired related homeobox 1 1 170662728-170739419 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA051084 Uncertain Supported Nucleus
Nucleoli Renal cancer:6.60e-10 (unfavourable) Mixed Mixed cervix, uterine: 135.2 PSIP1 LEDGF, p52, p75, PSIP2 ENSG00000164985 PC4 and SFRS1 interacting protein 1 9 15464066-15511019 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013718, HPA019697 Supported Validated Nucleoplasm Expressed in all Expressed in all cerebral cortex: 161.8 PTCH1 BCNS, NBCCS, PTCH ENSG00000185920 Patched 1 9 95442980-95517057 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB013717, HPA075072 Uncertain Approved Golgi apparatus Mixed Tissue enhanced cervix, uterine: 41.6 endometrium: 27.2 PTEN BZS, MHAM, MMAC1, PTEN1, TEP1 ENSG00000171862 Phosphatase and tensin homolog 10 87863113-87971930 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004076, HPA031335 Uncertain Supported Nucleoplasm
Cytosol Renal cancer:7.35e-4 (unfavourable) Expressed in all Mixed testis: 59.0 PTPN11 BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2 ENSG00000179295 Protein tyrosine phosphatase, non-receptor type 11 12 112418351-112509913 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB005377 Approved Supported Nucleus
Nucleoli
Actin filaments
Cytosol Expressed in all Expressed in all cerebral cortex: 124.6 PTPRB PTPB ENSG00000127329 Protein tyrosine phosphatase, receptor type, B 12 70515866-70637440 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB004782, HPA067868 Uncertain Approved Vesicles
Plasma membrane
Cell Junctions Renal cancer:1.02e-4 (favourable), Liver cancer:6.05e-4 (favourable) Expressed in all Mixed lung: 54.1 PTPRC CD45, GP180, LCA, T200 ENSG00000081237 Protein tyrosine phosphatase, receptor type, C 1 198638671-198757283 Cancer-related genes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000052, HPA000440, CAB002800, CAB056154, CAB068221 Supported Renal cancer:2.42e-4 (unfavourable) Expressed in all Expressed in all lymph node: 378.0 PTPRK R-PTP-kappa ENSG00000152894 Protein tyrosine phosphatase, receptor type, K 6 127968779-128520674 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA054056, HPA054822 Uncertain Supported Vesicles
Plasma membrane
Cell Junctions Renal cancer:9.33e-5 (favourable), Pancreatic cancer:1.99e-4 (unfavourable) Expressed in all Mixed gallbladder: 27.9 PWWP2A KIAA1935 ENSG00000170234 PWWP domain containing 2A 5 160061801-160119423 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA046733, HPA058233 Uncertain Supported Nucleoplasm
Focal adhesion sites Urothelial cancer:3.51e-4 (favourable), Renal cancer:3.70e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 15.4 RABEP1 neurocrescin, RAB5EP, rabaptin-5, RABPT5 ENSG00000029725 Rabaptin, RAB GTPase binding effector protein 1 17 5282265-5385812 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB004549, HPA019669, HPA024235, HPA024691 Supported Validated Vesicles Pancreatic cancer:6.43e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 89.9 RAC1 p21-Rac1, Rac-1, TC-25 ENSG00000136238 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 7 6374523-6403977 Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB035994, HPA047820 Approved Approved Nucleus
Nucleoli
Cytosol Liver cancer:1.74e-5 (unfavourable), Pancreatic cancer:4.57e-5 (unfavourable), Renal cancer:2.11e-4 (unfavourable), Lung cancer:4.59e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 282.4 RAD21 hHR21, KIAA0078, SCC1 ENSG00000164754 RAD21 cohesin complex component 8 116845935-116874866 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA020044, CAB022065 Supported Validated Nucleoplasm Liver cancer:1.71e-4 (unfavourable) Expressed in all Expressed in all testis: 161.7 RAD51B hREC2, R51H2, RAD51L1, REC2 ENSG00000182185 RAD51 paralog B 14 67819779-68730218 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB016191, HPA051869 Supported Approved Nucleoplasm
Nuclear bodies Mixed Mixed epididymis: 11.3 RAF1 c-Raf, CRAF, Raf-1 ENSG00000132155 Raf-1 proto-oncogene, serine/threonine kinase 3 12583601-12664226 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA002640, CAB019291 Approved Approved Nuclear speckles Expressed in all Expressed in all parathyroid gland: 100.1 RALGDS RalGEF, RGDS, RGF ENSG00000160271 Ral guanine nucleotide dissociation stimulator 9 133097720-133149334 Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA025961, CAB032582 Approved Approved Nucleus Cervical cancer:4.19e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 53.0 RANBP17 ENSG00000204764 RAN binding protein 17 5 170861870-171300015 Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA029568, HPA029569 Uncertain Approved Nuclear membrane
Nuclear bodies
Cytosol Mixed Tissue enhanced testis: 5.0 thyroid gland: 1.7 RANBP2 ADANE, ANE1, NUP358 ENSG00000153201 RAN binding protein 2 2 108719481-108785811 Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters Evidence at protein level HPA018437, HPA023960, CAB034063, HPA049497, HPA051675, HPA067564 Supported Validated Nuclear membrane
Vesicles Expressed in all Expressed in all parathyroid gland: 73.6 RAP1GDS1 SmgGDS ENSG00000138698 RAP1, GTP-GDP dissociation stimulator 1 4 98261384-98443861 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA019060 Approved Supported Cytosol Renal cancer:2.00e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 94.1 RARA NR1B1, RAR ENSG00000131759 Retinoic acid receptor, alpha 17 40309192-40357643 Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA058282 Supported Nucleus
Cytosol Endometrial cancer:2.60e-4 (favourable) Expressed in all Expressed in all gallbladder: 68.9 RB1 OSRC, PPP1R130, RB ENSG00000139687 Retinoblastoma 1 13 48303751-48481986 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000095, CAB016687, HPA050082 Supported Validated Nucleoplasm Ovarian cancer:6.92e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 36.0 RBM15 OTT, OTT1 ENSG00000162775 RNA binding motif protein 15 1 110338506-110346681 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB015201, HPA019824, HPA049642 Supported Validated Nucleoplasm Renal cancer:1.37e-4 (unfavourable), Liver cancer:7.61e-4 (unfavourable), Stomach cancer:7.97e-4 (favourable) Expressed in all Mixed bone marrow: 27.9 RECQL4 RecQ4 ENSG00000160957 RecQ helicase-like 4 8 144511288-144517845 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB017800, HPA025821 Supported Validated Nucleus Liver cancer:1.91e-4 (unfavourable) Expressed in all Mixed testis: 17.4 REL c-Rel, I-Rel ENSG00000162924 V-rel avian reticuloendotheliosis viral oncogene homolog 2 60881521-60931610 Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors Evidence at protein level CAB004404 Uncertain Mixed Mixed bone marrow: 29.9 RET CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51 ENSG00000165731 Ret proto-oncogene 10 43077027-43130351 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB002581, HPA008356, HPA008495, CAB018342 Approved Supported Supported Vesicles
Plasma membrane
Cytosol Endometrial cancer:5.02e-4 (unfavourable) Tissue enhanced Tissue enriched 5 parathyroid gland: 146.8 adrenal gland: 29.2 RHOA ARH12, ARHA, Rho12, RhoA, RHOH12 ENSG00000067560 Ras homolog family member A 3 49359145-49412998 Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB005052 Approved Supported Cytosol Renal cancer:3.21e-6 (favourable), Colorectal cancer:3.08e-4 (favourable), Liver cancer:9.15e-4 (unfavourable) Expressed in all Expressed in all lung: 592.9 RHOH ARHH, RhoH, TTF ENSG00000168421 Ras homolog family member H 4 40191053-40246967 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA030345 Uncertain Mixed Tissue enhanced lymph node: 99.6;tonsil: 80.6 appendix: 49.4 RMI2 BLAP18, C16orf75, MGC24665 ENSG00000175643 RecQ mediated genome instability 2 16 11249619-11351762 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA040995 Uncertain Supported Nuclear speckles
Cytosol Liver cancer:2.77e-5 (unfavourable), Cervical cancer:5.69e-5 (favourable) Expressed in all Mixed lymph node: 37.3 RNF213 C17orf27, KIAA1554, KIAA1618, MYMY2, NET57 ENSG00000173821 Ring finger protein 213 17 80260866-80398786 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA003347, HPA026790 Approved Supported Cytosol Endometrial cancer:4.65e-5 (unfavourable) Expressed in all Expressed in all parathyroid gland: 66.8 RNF43 DKFZp781H0392, FLJ20315, URCC ENSG00000108375 Ring finger protein 43 17 58352500-58417595 Cancer-related genes, Predicted membrane proteins Evidence at protein level HPA008079 Uncertain Renal cancer:6.04e-9 (favourable) Tissue enhanced Mixed duodenum: 24.1 ROS1 c-ros-1, MCF3, ROS ENSG00000047936 ROS proto-oncogene 1 , receptor tyrosine kinase 6 117288300-117425855 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA049098, HPA072424 Uncertain Approved Vesicles Tissue enriched Group enriched 18 epididymis: 69.7;lung: 47.3 seminal vesicle: 3.2 RPL10 DXS648, DXS648E, FLJ23544, L10, NOV, QM ENSG00000147403 Ribosomal protein L10 X 154389955-154409168 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins Evidence at protein level CAB010339, HPA011311 Supported Validated Endoplasmic reticulum
Cytosol Renal cancer:7.67e-6 (unfavourable) Expressed in all Expressed in all ovary: 9655.2 RPL5 L5, PPP1R135 ENSG00000122406 Ribosomal protein L5 1 92832025-92841924 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins Evidence at protein level HPA043717 Approved Renal cancer:6.81e-5 (unfavourable) Expressed in all Expressed in all ovary: 4031.6 RPN1 OST1 ENSG00000163902 Ribophorin I 3 128619970-128681075 Cancer-related genes, Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB009748, HPA026828, HPA051520 Supported Validated Endoplasmic reticulum Liver cancer:4.80e-4 (unfavourable) Expressed in all Expressed in all epididymis: 416.3 RSPO2 MGC35555 ENSG00000147655 R-spondin 2 8 107899316-108083648 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA024764, CAB025900, HPA053068 Approved Mixed Tissue enhanced cerebral cortex: 20.3;placenta: 25.6 prostate: 14.7 RSPO3 FLJ14440, THSD2 ENSG00000146374 R-spondin 3 6 127118604-127197765 Cancer-related genes, Predicted secreted proteins Evidence at protein level HPA029957 Approved Mixed Tissue enhanced endometrium: 102.8;smooth muscle: 102.3 placenta: 72.8 RUNX1 AML1, AMLCR1, CBFA2, PEBP2A2 ENSG00000159216 Runt-related transcription factor 1 21 34787801-36004667 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA004176, HPA037912 Supported Validated Nucleoplasm
Vesicles Renal cancer:3.44e-15 (unfavourable) Expressed in all Mixed breast: 33.8 RUNX1T1 AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 ENSG00000079102 Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 8 91954967-92103286 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA049852, HPA070951 Approved Approved Nucleoplasm Mixed Mixed cervix, uterine: 12.9 SBDS CGI-97, FLJ10917, SDS, SWDS ENSG00000126524 Shwachman-Bodian-Diamond syndrome 7 66987677-66995601 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA028891 Approved Supported Nucleus
Cytosol Breast cancer:1.49e-4 (unfavourable), Head and neck cancer:3.65e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 238.7 SDC4 amphiglycan, ryudocan, SYND4 ENSG00000124145 Syndecan 4 20 45325288-45348424 Cancer-related genes, Predicted membrane proteins, Transporters Evidence at protein level HPA005716, CAB013240 Supported Approved Golgi apparatus
Plasma membrane Renal cancer:2.44e-7 (favourable), Thyroid cancer:2.67e-4 (favourable), Pancreatic cancer:4.20e-4 (unfavourable) Expressed in all Expressed in all lung: 250.5 SDHAF2 C11orf79, FLJ20487, PGL2, SDH5 ENSG00000167985 Succinate dehydrogenase complex assembly factor 2 11 61430042-61447529 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA039464, HPA039732 Supported Supported Nucleoli
Mitochondria
Cytosol Expressed in all Expressed in all fallopian tube: 35.7 SDHB SDH, SDH1 ENSG00000117118 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1 17018722-17054170 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA002868, CAB009822, CAB068233, CAB068234, CAB068235 Supported Supported Nucleoplasm
Plasma membrane
Mitochondria Renal cancer:2.93e-7 (favourable) Expressed in all Expressed in all kidney: 213.3 SDHD PGL, PGL1 ENSG00000204370 Succinate dehydrogenase complex, subunit D, integral membrane protein 11 112086773-112120013 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA045727 Approved Renal cancer:1.99e-10 (favourable) Expressed in all Expressed in all kidney: 303.5 SEPT5 H5, HCDCREL-1, PNUTL1 ENSG00000184702 Septin 5 22 19714464-19724772 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB016120, HPA029095, HPA063885 Supported Approved Nucleoplasm
Actin filaments
Cytosol Renal cancer:6.87e-6 (unfavourable) Expressed in all Expressed in all parathyroid gland: 378.7 SEPT6 KIAA0128, MGC16619, MGC20339, SEP2, SEPT2 ENSG00000125354 Septin 6 X 119615724-119693370 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA003459, HPA005665 Supported Expressed in all Mixed lymph node: 142.3 SEPT9 AF17q25, KIAA0991, MSF, MSF1, PNUTL4, SeptD1 ENSG00000184640 Septin 9 17 77280569-77500596 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA042564, HPA050627 Approved Validated Actin filaments Liver cancer:1.61e-5 (unfavourable) Expressed in all Expressed in all lymph node: 272.5 SET 2PP2A, IPP2A2, PHAPII ENSG00000119335 SET nuclear proto-oncogene 9 128683424-128696400 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB005232, HPA063683 Supported Supported Nucleoplasm
Lipid droplets Liver cancer:9.41e-7 (unfavourable) Expressed in all Expressed in all lymph node: 366.1 SETBP1 KIAA0437, SEB ENSG00000152217 SET binding protein 1 18 44680173-45068510 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA049022, HPA057259 Uncertain Supported Nucleus
Nuclear bodies
Cytosol Renal cancer:6.34e-8 (favourable) Mixed Expressed in all seminal vesicle: 13.8 SETD2 FLJ23184, HIF-1, HYPB, KIAA1732, KMT3A ENSG00000181555 SET domain containing 2 3 47016429-47163967 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA042451 Approved Approved Nuclear speckles
Cytosol Renal cancer:7.99e-6 (favourable), Melanoma:8.19e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 30.5 SF3B1 Hsh155, Prp10, PRPF10, SAP155, SF3b155 ENSG00000115524 Splicing factor 3b, subunit 1, 155kDa 2 197389784-197435091 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA050275 Approved Validated Nuclear speckles Expressed in all Expressed in all endometrium: 345.5 SFPQ PPP1R140, PSF ENSG00000116560 Splicing factor proline/glutamine-rich 1 35176378-35193148 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB009886, HPA047513, HPA054689 Supported Validated Nucleoplasm Liver cancer:7.91e-13 (unfavourable), Breast cancer:9.56e-5 (favourable) Expressed in all Expressed in all bone marrow: 135.7 SH2B3 IDDM20, LNK ENSG00000111252 SH2B adaptor protein 3 12 111405948-111451623 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA005483 Approved Approved Nucleoplasm Renal cancer:6.20e-4 (unfavourable) Expressed in all Expressed in all spleen: 51.9 SH3GL1 CNSA1, EEN, MGC111371, SH3D2B, SH3P8 ENSG00000141985 SH3-domain GRB2-like 1 19 4360370-4400547 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA021485 Approved Validated Cytosol Renal cancer:9.36e-8 (unfavourable), Liver cancer:1.10e-4 (unfavourable), Cervical cancer:1.50e-4 (favourable), Endometrial cancer:1.86e-4 (favourable) Expressed in all Expressed in all esophagus: 115.0 SHTN1 KIAA1598, shootin-1, shootin1 ENSG00000187164 Shootin 1 10 116881482-117126586 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA037942, HPA037943 Supported Approved Nucleus
Plasma membrane
Cytosol Urothelial cancer:5.08e-6 (unfavourable), Prostate cancer:5.07e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 36.2 parathyroid gland: 18.6 SLC34A2 NAPI-3B ENSG00000157765 Solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 4 25655301-25678748 Cancer-related genes, Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA037989 Supported Tissue enhanced Tissue enriched 10 lung: 1127.5 fallopian tube: 111.7 SLC45A3 IPCA-2, IPCA-6, IPCA-8, PCANAP2, PCANAP6, PCANAP8, prostein ENSG00000158715 Solute carrier family 45, member 3 1 205657851-205680459 Cancer-related genes, Predicted membrane proteins, Transporters Evidence at protein level HPA019073, HPA019075 Supported Approved Nucleoplasm
Vesicles Endometrial cancer:4.04e-5 (unfavourable), Urothelial cancer:7.33e-5 (favourable) Tissue enriched Tissue enriched 25 prostate: 430.6 stomach: 16.9 SMAD4 DPC4, MADH4 ENSG00000141646 SMAD family member 4 18 51028394-51085045 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA019154 Approved Supported Nucleoplasm
Centrosome
Cytosol Renal cancer:1.92e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 38.7 SMARCA4 BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2 ENSG00000127616 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 19 10961001-11065395 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004208 Supported Supported Nucleoplasm Liver cancer:1.11e-4 (unfavourable) Expressed in all Expressed in all testis: 39.5 SMARCB1 BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1 ENSG00000099956 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 22 23786963-23834516 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009196, HPA018248, HPA019127 Supported Supported Nucleoplasm
Nucleoli fibrillar center Renal cancer:1.14e-6 (favourable), Liver cancer:6.52e-4 (unfavourable) Expressed in all Expressed in all testis: 51.2 SMARCD1 BAF60A, CRACD1, Rsc6p ENSG00000066117 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 12 50084972-50100712 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA004101 Supported Approved Nucleoplasm
Vesicles Liver cancer:2.53e-8 (unfavourable) Expressed in all Expressed in all parathyroid gland: 84.7 SMARCE1 BAF57 ENSG00000073584 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 17 40624962-40648508 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003916, CAB037318 Supported Supported Nucleoplasm Expressed in all Expressed in all endometrium: 72.9 SMO FZD11, SMOH ENSG00000128602 Smoothened, frizzled class receptor 7 129188872-129213545 Cancer-related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB011446 Approved Expressed in all Mixed ovary: 30.3 SND1 p100, TDRD11 ENSG00000197157 Staphylococcal nuclease and tudor domain containing 1 7 127652180-128092609 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002529, HPA002632, CAB019323 Supported Validated Cytosol Endometrial cancer:1.95e-4 (favourable) Expressed in all Expressed in all placenta: 121.5 SOCS1 Cish1, JAB, SOCS-1, SSI-1, TIP3 ENSG00000185338 Suppressor of cytokine signaling 1 16 11254405-11256179 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB010355, HPA074108 Approved Supported Nucleoplasm
Cytoplasmic bodies Renal cancer:1.08e-6 (unfavourable), Head and neck cancer:1.10e-4 (favourable) Expressed in all Tissue enhanced appendix: 20.0 lymph node: 15.9 SOX2 ENSG00000181449 SRY (sex determining region Y)-box 2 3 181711924-181714436 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB010648, HPA045725 Approved Supported Nucleoplasm Tissue enhanced Tissue enriched 8 cerebral cortex: 118.3 esophagus: 14.9 SPECC1 CYTSB, FLJ36955, HCMOGT-1, NSP ENSG00000128487 Sperm antigen with calponin homology and coiled-coil domains 1 17 20009344-20319026 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA021421, HPA021430 Approved Lung cancer:1.06e-5 (unfavourable) Expressed in all Expressed in all testis: 67.2 SPEN KIAA0929, MINT, RBM15C, SHARP ENSG00000065526 Spen family transcriptional repressor 1 15847864-15940460 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA015825, HPA050257 Supported Validated Nucleoplasm Expressed in all Expressed in all parathyroid gland: 38.3 SRGAP3 ARHGAP14, KIAA0411, MEGAP, SRGAP2, WRP ENSG00000196220 SLIT-ROBO Rho GTPase activating protein 3 3 8980591-9363053 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA036959, HPA044074 Supported Approved Nucleoplasm Mixed Tissue enhanced cerebral cortex: 26.6;fallopian tube: 17.3 cervix, uterine: 7.9 SRSF2 PR264, SC-35, SC35, SFRS2, SFRS2A ENSG00000161547 Serine/arginine-rich splicing factor 2 17 76734115-76737374 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA049905 Supported Approved Nucleus
Cytosol Liver cancer:3.53e-8 (unfavourable), Renal cancer:1.05e-7 (unfavourable), Endometrial cancer:8.73e-4 (unfavourable), Urothelial cancer:9.87e-4 (favourable) Expressed in all Expressed in all lymph node: 128.8 SRSF3 SFRS3, SRp20 ENSG00000112081 Serine/arginine-rich splicing factor 3 6 36594353-36605600 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB012986, HPA056981 Supported Supported Nucleoplasm Liver cancer:6.22e-5 (unfavourable), Ovarian cancer:1.37e-4 (favourable), Melanoma:1.95e-4 (unfavourable), Renal cancer:2.02e-4 (unfavourable), Colorectal cancer:2.56e-4 (favourable) Expressed in all Expressed in all lymph node: 141.5 SS18 SSXT, SYT ENSG00000141380 Synovial sarcoma translocation, chromosome 18 18 26016253-26091217 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA055741, HPA059539 Supported Approved Nucleoplasm
Cytosol Renal cancer:4.86e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 74.4 SS18L1 KIAA0693 ENSG00000184402 Synovial sarcoma translocation gene on chromosome 18-like 1 20 62143795-62182484 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB011827, HPA059046 Approved Supported Nucleoplasm
Cytosol Head and neck cancer:8.00e-5 (favourable), Lung cancer:3.74e-4 (favourable) Expressed in all Expressed in all skin: 23.7 SSX1 CT5.1 ENSG00000126752 Synovial sarcoma, X breakpoint 1 X 48255317-48267444 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA045683 Supported Approved Nucleus
Nucleoli Tissue enhanced Tissue enriched 32 testis: 12.7 thyroid gland: 0.3 SSX2 CT5.2a, HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX ENSG00000241476 Synovial sarcoma, X breakpoint 2 X 52644567-52707189 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA045683, CAB046020 Supported Not detected Tissue enriched 112 testis: 46.0 thyroid gland: 0.4 SSX4 CT5.4 ENSG00000268009 Synovial sarcoma, X breakpoint 4 X 48383516-48393347 Cancer-related genes, Predicted intracellular proteins Evidence at transcript level HPA045683 Approved Not detected Tissue enriched 15 testis: 3.8 fallopian tube: 0.2 STAG2 SA-2, SA2, SCC3B ENSG00000101972 Stromal antigen 2 X 123960212-124422664 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002857 Supported Expressed in all Expressed in all parathyroid gland: 110.6 STAT3 APRF ENSG00000168610 Signal transducer and activator of transcription 3 (acute-phase response factor) 17 42313324-42388568 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001671, CAB003859, HPA058603, CAB068241, CAB068242 Supported Supported Nucleoplasm
Cytosol Expressed in all Expressed in all gallbladder: 127.9 STAT5B ENSG00000173757 Signal transducer and activator of transcription 5B 17 42199168-42276707 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004298, HPA042128, HPA049883, HPA051156 Approved Renal cancer:2.39e-5 (favourable), Pancreatic cancer:1.63e-4 (favourable), Endometrial cancer:9.37e-4 (favourable) Expressed in all Expressed in all endometrium: 70.8 STAT6 D12S1644, IL-4-STAT ENSG00000166888 Signal transducer and activator of transcription 6, interleukin-4 induced 12 57095408-57132139 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001861 Approved Validated Nucleoplasm
Cytosol Urothelial cancer:1.14e-4 (favourable), Endometrial cancer:1.69e-4 (favourable), Thyroid cancer:7.76e-4 (favourable) Expressed in all Expressed in all skin: 164.0 STIL MCPH7, SIL ENSG00000123473 SCL/TAL1 interrupting locus 1 47250139-47314147 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA046543 Approved Plasma membrane
Cytosol Pancreatic cancer:1.33e-4 (unfavourable) Mixed Mixed testis: 12.5 STK11 LKB1, PJS ENSG00000118046 Serine/threonine kinase 11 19 1177558-1228435 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB016231, HPA017254, CAB022105, HPA067481 Approved Supported Nucleoplasm
Cytosol Endometrial cancer:3.69e-5 (favourable), Head and neck cancer:1.96e-4 (favourable) Expressed in all Expressed in all testis: 70.3 STRN SG2NA ENSG00000115808 Striatin, calmodulin binding protein 2 36843640-36966472 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA017286 Approved Approved Nucleoplasm
Cytosol Renal cancer:2.27e-4 (favourable) Expressed in all Expressed in all esophagus: 23.9 SUFU PRO1280, SUFUH, SUFUXL ENSG00000107882 Suppressor of fused homolog (Drosophila) 10 102503987-102633535 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA008700 Supported Supported Nucleus Expressed in all Mixed parathyroid gland: 15.8 SUZ12 CHET9, JJAZ1, KIAA0160 ENSG00000178691 SUZ12 polycomb repressive complex 2 subunit 17 31937018-32001045 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA057436 Approved Approved Nucleus
Nucleoli
Nuclear bodies Expressed in all Expressed in all testis: 50.5 SYK ENSG00000165025 Spleen tyrosine kinase 9 90801787-90898549 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA001384, CAB007773 Supported Approved Vesicles
Plasma membrane
Cytosol Expressed in all Mixed parathyroid gland: 94.2 TAF15 hTAFII68, Npl3, RBP56, TAF2N ENSG00000270647 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 17 35713791-35864615 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA052059, HPA063647 Supported Validated Nucleoplasm Expressed in all Expressed in all lymph node: 61.9 TAL1 bHLHa17, SCL, TCL5 ENSG00000162367 T-cell acute lymphocytic leukemia 1 1 47216290-47232220 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017805, HPA047866 Approved Approved Nucleus Mixed Tissue enhanced bone marrow: 17.7 placenta: 10.0 TAL2 bHLHa19 ENSG00000186051 T-cell acute lymphocytic leukemia 2 9 105662457-105663112 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030886 Uncertain Approved Cytosol Renal cancer:2.69e-4 (favourable) Tissue enhanced Group enriched 5 kidney: 3.4;skeletal muscle: 4.8 epididymis: 0.8 TBL1XR1 C21, DC42, FLJ12894, IRA1, TBLR1 ENSG00000177565 Transducin (beta)-like 1 X-linked receptor 1 3 177019355-177197396 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019182 Supported Approved Nucleoplasm Liver cancer:1.08e-7 (unfavourable), Renal cancer:4.25e-5 (unfavourable), Glioma:7.23e-5 (favourable) Expressed in all Expressed in all thyroid gland: 61.2 TBX3 TBX3-ISO, UMS, XHL ENSG00000135111 T-box 3 12 114670254-114684164 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005799 Approved Nucleoplasm
Cytosol Urothelial cancer:3.28e-4 (favourable) Expressed in all Tissue enhanced adrenal gland: 201.8 prostate: 114.3 TCEA1 GTF2S, SII, TCEA, TF2S, TFIIS ENSG00000187735 Transcription elongation factor A (SII), 1 8 53966552-54022529 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA043786 Approved Supported Nucleus
Nucleoli Renal cancer:3.75e-5 (unfavourable) Expressed in all Expressed in all thyroid gland: 199.1 TCF12 bHLHb20, HEB, HsT17266, HTF4 ENSG00000140262 Transcription factor 12 15 56918623-57299281 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level CAB004432, HPA065827 Approved Supported Nucleoplasm
Nuclear speckles Renal cancer:5.24e-5 (unfavourable), Melanoma:8.89e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 115.4 TCF3 bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, VDIR ENSG00000071564 Transcription factor 3 19 1609290-1652605 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB018351, HPA049808, HPA062476 Approved Validated Nucleoplasm Renal cancer:1.53e-4 (unfavourable), Liver cancer:2.46e-4 (unfavourable) Expressed in all Expressed in all lymph node: 104.6 TCF7L2 TCF-4, TCF4 ENSG00000148737 Transcription factor 7-like 2 (T-cell specific, HMG-box) 10 112950250-113167678 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB013535, HPA038800 Supported Supported Nucleoplasm
Nuclear bodies Expressed in all Expressed in all endometrium: 33.6 TCL1A TCL1 ENSG00000100721 T-cell leukemia/lymphoma 1A 14 95709967-95714196 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB004045, HPA016604 Supported Tissue enriched Tissue enhanced lymph node: 328.5;tonsil: 204.6 spleen: 79.4 TERT EST2, hEST2, TCS1, TP2, TRT ENSG00000164362 Telomerase reverse transcriptase 5 1253147-1295069 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA054641, HPA065897 Validated Nucleoplasm Mixed Not detected lymph node,testis: 0.5 TET1 bA119F7.1, CXXC6, KIAA1676, LCX ENSG00000138336 Tet methylcytosine dioxygenase 1 10 68560656-68694482 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB014886, HPA019032, HPA057273 Approved Supported Nucleus
Nuclear membrane Tissue enriched Mixed parathyroid gland: 2.4 TET2 FLJ20032, KIAA1546 ENSG00000168769 Tet methylcytosine dioxygenase 2 4 105145875-105279816 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA043135 Supported Approved Nucleoplasm Mixed Mixed bone marrow: 15.8 TFE3 bHLHe33, TFEA ENSG00000068323 Transcription factor binding to IGHM enhancer 3 X 49028726-49043486 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA023881 Approved Supported Nucleoplasm
Cytosol Renal cancer:2.19e-8 (unfavourable), Liver cancer:6.03e-5 (unfavourable) Expressed in all Expressed in all seminal vesicle: 24.2 TFEB bHLHe35, TCFEB ENSG00000112561 Transcription factor EB 6 41683978-41736259 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA049532 Supported Nucleoplasm Renal cancer:1.06e-5 (favourable), Pancreatic cancer:4.77e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 53.4 TFG FLJ36137, SPG57, TF6 ENSG00000114354 TRK-fused gene 3 100709331-100748966 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA019473, HPA052206 Approved Approved Vesicles
Cytosol Pancreatic cancer:1.50e-4 (unfavourable), Liver cancer:5.48e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 161.6 TFPT amida, FB1, INO80F ENSG00000105619 TCF3 (E2A) fusion partner (in childhood Leukemia) 19 54107013-54115675 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA034958, HPA058534 Approved Supported Nucleoplasm
Nuclear membrane Pancreatic cancer:3.13e-4 (favourable), Colorectal cancer:5.13e-4 (unfavourable), Liver cancer:5.25e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 10.6 TFRC CD71, p90, TFR1 ENSG00000072274 Transferrin receptor 3 196027183-196082189 Cancer-related genes, CD markers, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB000153, HPA028598 Supported Supported Endosomes
Lysosomes Liver cancer:1.15e-4 (unfavourable), Thyroid cancer:2.96e-4 (unfavourable), Cervical cancer:3.67e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 157.6 THRAP3 TRAP150 ENSG00000054118 Thyroid hormone receptor associated protein 3 1 36224416-36305357 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA012041, CAB017472, HPA063765 Supported Validated Nuclear speckles Stomach cancer:5.36e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 97.5 TLX3 HOX11L2, RNX ENSG00000164438 T-cell leukemia homeobox 3 5 171309284-171312134 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA074512 Approved Nucleoplasm
Centrosome Tissue enhanced Not detected all non-specific tissues: 0.0 TMPRSS2 PRSS10 ENSG00000184012 Transmembrane protease, serine 2 21 41464551-41531116 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA034493, HPA035787 Supported Supported Nucleoplasm
Cell Junctions Renal cancer:7.86e-6 (favourable), Endometrial cancer:2.56e-4 (favourable) Tissue enriched Tissue enhanced prostate: 495.7 stomach: 142.5 TNFAIP3 A20, OTUD7C ENSG00000118503 Tumor necrosis factor, alpha-induced protein 3 6 137867188-137883312 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002116 Approved Approved Centrosome
Cytosol Renal cancer:6.05e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 345.8 TNFRSF14 ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 ENSG00000157873 Tumor necrosis factor receptor superfamily, member 14 1 2555639-2565382 Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA006404, CAB026150, CAB030007 Approved Approved Cytosol
Rods & Rings Urothelial cancer:7.79e-6 (favourable), Endometrial cancer:8.01e-6 (favourable), Breast cancer:4.39e-5 (favourable) Expressed in all Expressed in all duodenum: 46.7 TOP1 ENSG00000198900 Topoisomerase (DNA) I 20 41028818-41124487 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level CAB009058, HPA019039 Supported Supported Nucleus
Nucleoli fibrillar center Liver cancer:6.42e-4 (unfavourable) Expressed in all Expressed in all lymph node: 71.8 TP53 LFS1, p53 ENSG00000141510 Tumor protein p53 17 7661779-7687550 Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters Evidence at protein level CAB002973, CAB039238, CAB039239, HPA051244, CAB072876 Supported Validated Nucleoplasm Endometrial cancer:1.35e-4 (favourable), Prostate cancer:5.01e-4 (unfavourable) Expressed in all Expressed in all fallopian tube: 50.3 TPM3 NEM1, TRK ENSG00000143549 Tropomyosin 3 1 154155304-154194648 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA000261, HPA009066, HPA047089, HPA053624 Approved Approved Actin filaments
Cytosol Liver cancer:6.73e-6 (unfavourable), Ovarian cancer:2.39e-5 (favourable), Renal cancer:3.12e-5 (unfavourable), Pancreatic cancer:3.65e-4 (unfavourable), Lung cancer:4.01e-4 (unfavourable) Expressed in all Tissue enriched 7 skeletal muscle: 2869.9 bone marrow: 429.2 TPM4 ENSG00000167460 Tropomyosin 4 19 16067021-16103005 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004685, HPA047089, HPA053624 Approved Approved Actin filaments
Cytosol Renal cancer:1.26e-10 (unfavourable), Pancreatic cancer:3.07e-4 (unfavourable) Expressed in all Expressed in all smooth muscle: 808.6 TPR ENSG00000047410 Translocated promoter region, nuclear basket protein 1 186311652-186375693 Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters Evidence at protein level HPA019661, HPA019663, HPA024336 Supported Validated Nuclear membrane Liver cancer:1.06e-4 (unfavourable), Head and neck cancer:4.71e-4 (favourable) Expressed in all Expressed in all testis: 78.8 TRAF7 DKFZp586I021, MGC7807, RFWD1, RNF119 ENSG00000131653 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 16 2155698-2178129 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA041229 Approved Supported Vesicles
Plasma membrane Expressed in all Expressed in all duodenum: 41.1 TRIM24 hTIF1, RNF82, TIF1, Tif1a ENSG00000122779 Tripartite motif containing 24 7 138460334-138589993 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA043495, HPA061717 Approved Validated Nucleoplasm Lung cancer:6.57e-4 (favourable), Liver cancer:9.94e-4 (unfavourable) Expressed in all Expressed in all testis: 49.5 TRIM27 RFP, RNF76 ENSG00000204713 Tripartite motif containing 27 6 28903002-28923989 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA048684, HPA053408 Supported Approved Nucleus
Nucleoli Renal cancer:3.50e-6 (unfavourable), Urothelial cancer:2.71e-4 (favourable) Expressed in all Mixed appendix: 5.8 TRIM33 FLJ11429, KIAA1113, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA ENSG00000197323 Tripartite motif containing 33 1 114392777-114511160 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA004345 Supported Approved Nucleoplasm
Vesicles Colorectal cancer:6.20e-4 (favourable), Head and neck cancer:8.93e-4 (favourable) Expressed in all Expressed in all testis: 46.0 TRIP11 CEV14, GMAP-210, GMAP210, Trip230 ENSG00000100815 Thyroid hormone receptor interactor 11 14 91965991-92040896 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA002570, HPA070684 Supported Validated Nucleus
Golgi apparatus Renal cancer:1.78e-6 (favourable) Expressed in all Expressed in all parathyroid gland: 37.7 TRRAP PAF400, TR-AP, Tra1 ENSG00000196367 Transformation/transcription domain-associated protein 7 98877933-99013243 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA054376 Supported Nucleoplasm
Golgi apparatus Liver cancer:8.77e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 22.2 TSC1 hamartin, KIAA0243, LAM, TSC ENSG00000165699 Tuberous sclerosis 1 9 132891348-132944633 Cancer-related genes, Disease related genes, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB011568, CAB012481, HPA074132 Supported Validated Cytosol Liver cancer:6.03e-6 (unfavourable), Renal cancer:7.91e-4 (favourable), Pancreatic cancer:8.01e-4 (favourable) Expressed in all Expressed in all testis: 34.3 TSC2 LAM, PPP1R160, TSC4, tuberin ENSG00000103197 Tuberous sclerosis 2 16 2047465-2088720 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB002225, HPA030409, HPA049679 Approved Validated Cytosol Pancreatic cancer:5.06e-4 (favourable) Expressed in all Expressed in all seminal vesicle: 35.7 TSHR LGR3 ENSG00000165409 Thyroid stimulating hormone receptor 14 80954989-81146302 Cancer-related genes, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000473 Approved Tissue enriched Tissue enriched 277 thyroid gland: 443.8 lymph node: 1.6 TTL MGC46235 ENSG00000114999 Tubulin tyrosine ligase 2 112482154-112541739 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA066819 Approved Nucleoplasm
Vesicles Liver cancer:5.65e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 4.5 U2AF1 RN, RNU2AF1, U2AF35, U2AFBP ENSG00000160201 U2 small nuclear RNA auxiliary factor 1 21 43092956-43107587 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA044833, HPA052083 Supported Validated Nucleoplasm Not detected Expressed in all thyroid gland: 71.4 UBR5 DD5, EDD, EDD1, HYD, KIAA0896 ENSG00000104517 Ubiquitin protein ligase E3 component n-recognin 5 8 102253012-102412841 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA053688 Supported Nucleoplasm
Cytosol Liver cancer:1.26e-4 (unfavourable) Expressed in all Expressed in all testis: 79.7 USP6 HRP1, Tre-2, TRE17, Tre2, TRESMCR ENSG00000129204 Ubiquitin specific peptidase 6 17 5116438-5175034 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA046969 Uncertain Uncertain Vesicles Tissue enriched Tissue enhanced testis: 17.8 skeletal muscle: 7.5 VHL VHL1 ENSG00000134086 Von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 3 10141008-10152220 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB005430, HPA031631, HPA031632 Uncertain Validated Nucleoplasm
Cytosol Liver cancer:1.32e-5 (unfavourable), Breast cancer:9.02e-5 (unfavourable), Stomach cancer:7.84e-4 (favourable) Expressed in all Expressed in all lymph node: 35.2 VTI1A MVti1, Vti1-rp2, Vti1a ENSG00000151532 Vesicle transport through interaction with t-SNAREs 1A 10 112446998-112818744 Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA054108 Supported Supported Golgi apparatus
Vesicles Liver cancer:6.50e-5 (unfavourable), Renal cancer:7.27e-5 (favourable) Expressed in all Mixed parathyroid gland: 12.1 WAS IMD2, THC, WASP, WASPA ENSG00000015285 Wiskott-Aldrich syndrome X 48676596-48691427 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA002022, CAB004290 Supported Renal cancer:5.58e-6 (unfavourable), Head and neck cancer:3.78e-4 (favourable), Endometrial cancer:4.95e-4 (favourable) Expressed in all Tissue enhanced appendix: 71.0;lymph node: 61.6;spleen: 70.8 bone marrow: 37.6 WHSC1 MMSET, NSD2 ENSG00000109685 Wolf-Hirschhorn syndrome candidate 1 4 1871424-1982207 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA015801, CAB068246, CAB068247 Supported Supported Nucleus Liver cancer:2.61e-4 (unfavourable), Renal cancer:7.19e-4 (unfavourable) Expressed in all Expressed in all testis: 66.9 WHSC1L1 FLJ20353, NSD3 ENSG00000147548 Wolf-Hirschhorn syndrome candidate 1-like 1 8 38269697-38382272 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA005659, CAB013721, HPA018893 Uncertain Approved Nucleoplasm
Mitochondria Pancreatic cancer:7.48e-4 (unfavourable) Expressed in all Expressed in all placenta: 47.5 WIF1 ENSG00000156076 WNT inhibitory factor 1 12 65050626-65121566 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA039104 Approved Tissue enhanced Tissue enriched 6 lung: 159.7 cerebral cortex: 26.5 WRN RECQ3, RECQL2 ENSG00000165392 Werner syndrome, RecQ helicase-like 8 31033801-31173769 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA028661 Approved Supported Nuclear speckles Expressed in all Mixed endometrium: 14.7 WT1 AWT1, GUD, WAGR, WIT-2 ENSG00000184937 Wilms tumor 1 11 32387775-32435630 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000327, HPA035717, HPA053848 Supported Supported Nucleoplasm Tissue enriched Tissue enhanced endometrium: 112.0;fallopian tube: 123.1;smooth muscle: 78.9 testis: 53.8 WWTR1 DKFZp586I1419, TAZ ENSG00000018408 WW domain containing transcription regulator 1 3 149517235-149736714 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA007415, CAB017483, CAB068248 Approved Validated Nucleoplasm
Nuclear bodies
Cytosol Expressed in all Mixed endometrium: 70.7 XPA XP1, XPAC ENSG00000136936 Xeroderma pigmentosum, complementation group A 9 97674909-97697357 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB000155, HPA056856 Supported Approved Nucleus
Cytokinetic bridge Renal cancer:4.28e-5 (favourable) Expressed in all Expressed in all thyroid gland: 38.9 XPC RAD4, XPCC ENSG00000154767 Xeroderma pigmentosum, complementation group C 3 14145147-14178783 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009932, HPA035707, HPA069673 Supported Validated Nucleus
Plasma membrane Renal cancer:4.14e-7 (favourable), Urothelial cancer:2.46e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 51.3 XPO1 CRM1, emb ENSG00000082898 Exportin 1 2 61477849-61538626 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters Evidence at protein level CAB010184, HPA042933 Supported Validated Nucleoplasm
Nuclear membrane
Vesicles
Cytosol Liver cancer:1.84e-5 (unfavourable), Renal cancer:3.74e-4 (unfavourable) Expressed in all Expressed in all testis: 138.5 YWHAE FLJ45465 ENSG00000108953 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 17 1344272-1400378 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA008445, CAB016200, CAB021109, CAB047350 Approved Uncertain Cytosol Endometrial cancer:6.48e-6 (favourable) Expressed in all Expressed in all cerebral cortex: 452.9 ZBTB16 PLZF, ZNF145 ENSG00000109906 Zinc finger and BTB domain containing 16 11 114059593-114250676 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001499, CAB004540 Uncertain Renal cancer:2.21e-4 (favourable) Tissue enhanced Mixed ovary: 59.6 ZCCHC8 DKFZp434E2220 ENSG00000033030 Zinc finger, CCHC domain containing 8 12 122471600-122501073 Cancer-related genes, Predicted intracellular proteins Evidence at protein level HPA037483, HPA037484 Supported Validated Nucleoplasm
Nuclear bodies Renal cancer:5.36e-4 (unfavourable), Melanoma:7.40e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 33.1 ZMYM2 FIM, MYM, RAMP, ZNF198 ENSG00000121741 Zinc finger, MYM-type 2 13 19958670-20091829 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA031765 Approved Approved Nucleoplasm
Endoplasmic reticulum Urothelial cancer:6.07e-4 (favourable) Expressed in all Expressed in all testis: 87.6 ZNF331 RITA, ZNF361, ZNF463 ENSG00000130844 Zinc finger protein 331 19 53520981-53580269 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA063157 Approved Nucleoplasm Stomach cancer:4.79e-4 (unfavourable), Thyroid cancer:7.43e-4 (unfavourable) Expressed in all Expressed in all adrenal gland: 210.3 ZNF384 CAGH1A, CIZ, NMP4, NP, TNRC1 ENSG00000126746 Zinc finger protein 384 12 6666477-6689572 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA004051 Supported Supported Nucleoplasm Expressed in all Expressed in all endometrium: 65.7 ZNF521 EHZF, Evi3 ENSG00000198795 Zinc finger protein 521 18 25061926-25352190 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA023056, HPA023849 Approved Approved Nucleoplasm Mixed Mixed spleen: 29.4