Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific CASR FHH, GPRC2A, HHC, HHC1, NSHPT ENSG00000036828 Calcium-sensing receptor 3 122183683-122286503 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA039686, HPA050335 Supported Tissue enriched Tissue enriched 60 parathyroid gland: 1627.2 kidney: 27.0 GABBR1 GPRC3A, hGB1a ENSG00000204681 Gamma-aminobutyric acid (GABA) B receptor, 1 6 29555629-29633976 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA050483, HPA058459 Uncertain Uncertain Centrosome Renal cancer:3.77e-10 (unfavourable), Pancreatic cancer:2.54e-5 (favourable) Expressed in all Tissue enhanced cerebral cortex: 20.9 spleen: 13.3 GABBR2 GABABR2, GPR51, GPRC3B, HG20 ENSG00000136928 Gamma-aminobutyric acid (GABA) B receptor, 2 9 98288082-98709197 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA013820, HPA031684 Supported Group enriched Tissue enriched 19 cerebral cortex: 88.4 adrenal gland: 4.6 GPR156 GABABL, PGR28 ENSG00000175697 G protein-coupled receptor 156 3 120164645-120285094 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028642, HPA028644 Uncertain Supported Plasma membrane Mixed Tissue enhanced testis: 5.1 fallopian tube: 1.8 GPR158 KIAA1136 ENSG00000151025 G protein-coupled receptor 158 10 25175062-25602226 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013185 Uncertain Approved Cytosol Mixed Tissue enriched 17 cerebral cortex: 17.9 testis: 1.0 GPRC5A PEIG-1, RAI3, RAIG1, TIG1 ENSG00000013588 G protein-coupled receptor, class C, group 5, member A 12 12890782-12917937 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA007928, HPA046526 Approved Validated Vesicles
Plasma membrane Pancreatic cancer:4.63e-6 (unfavourable), Renal cancer:9.02e-5 (unfavourable) Mixed Tissue enhanced lung: 302.3 thyroid gland: 90.7 GPRC5B RAIG-2 ENSG00000167191 G protein-coupled receptor, class C, group 5, member B 16 19856691-19886167 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA015247 Approved Supported Nucleus
Nucleoli
Vesicles Colorectal cancer:9.27e-5 (unfavourable), Renal cancer:6.30e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 309.2 testis: 66.5 GPRC5C RAIG-3 ENSG00000170412 G protein-coupled receptor, class C, group 5, member C 17 74424851-74451653 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA029776 Supported Uncertain Nucleus
Microtubule organizing center
Cytosol Renal cancer:1.58e-5 (favourable) Expressed in all Mixed thyroid gland: 103.7 GPRC5D ENSG00000111291 G protein-coupled receptor, class C, group 5, member D 12 12940775-12952147 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA071909 Approved Head and neck cancer:5.09e-4 (favourable) Mixed Mixed testis: 5.2 GRM1 GPRC1A, mGlu1, MGLUR1, PPP1R85 ENSG00000152822 Glutamate receptor, metabotropic 1 6 146027646-146437598 Disease related genes, G-protein coupled receptors, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA015701 Approved Approved Vesicles Not detected Tissue enhanced cerebral cortex: 7.1 heart muscle: 1.4 GRM2 GPRC1B, mGlu2, MGLUR2 ENSG00000164082 Glutamate receptor, metabotropic 2 3 51707070-51718613 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA065166 Approved Tissue enhanced Tissue enriched 10 cerebral cortex: 4.4 testis: 0.4 GRM4 GPRC1D, mGlu4, MGLUR4 ENSG00000124493 Glutamate receptor, metabotropic 4 6 34018645-34155622 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB022096 Supported Tissue enhanced Tissue enhanced cerebral cortex: 2.9 testis: 0.7 GRM6 CSNB1B, GPRC1F, mGlu6, MGLUR6 ENSG00000113262 Glutamate receptor, metabotropic 6 5 178978327-178996206 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA014511 Supported Not detected Not detected testis: 0.8 GRM7 GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87 ENSG00000196277 Glutamate receptor, metabotropic 7 3 6770001-7741533 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA015964 Uncertain Cytosol Not detected Tissue enhanced cerebral cortex: 10.1;parathyroid gland: 7.0 smooth muscle: 3.4 GRM8 GLUR8, GPRC1H, mGlu8, MGLUR8 ENSG00000179603 Glutamate receptor, metabotropic 8 7 126438598-127253294 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA051481 Uncertain Tissue enhanced Tissue enhanced cerebral cortex: 4.1 testis: 2.9 TAS1R1 GPR70, T1R1, TR1 ENSG00000173662 Taste receptor, type 1, member 1 1 6555181-6579757 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at transcript level HPA034579, HPA034580 Approved Mixed Tissue enriched 7 testis: 4.2 gallbladder,skin: 0.5 TAS1R3 T1R3 ENSG00000169962 Taste receptor, type 1, member 3 1 1331314-1335306 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA053439 Approved Mixed Group enriched 5 epididymis: 14.7;salivary gland: 3.3 appendix: 1.7