High magnification of pancreas showing the expression of chromogranin A (CHGA) in the islets of Langerhans. Cytoplasmic expression is seen in all endocrine cells present in the islets of Langerhans.
Chromogranin A (CHGA) - Marker for neuroendocrine cells
The CHGA gene belongs to the granin-family of neuroendocrine secretory proteins. The gene encodes for Chromogranin A, which is found in neurons and endocrine cells. Chromogranin A inhibits insulin-release from the pancreas, but is also a precursor of several bioactive peptides that regulate the neuroendocrine function of the secreting cell itself, or cells nearby. In a clinical setting CHGA is used to indicate neuroendocrine tumors including carcinoids.
in the protein atlas.