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Jumonji, AT rich interactive domain 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001889 [liver development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0031061 [negative regulation of histone methylation] GO:0035097 [histone methyltransferase complex] GO:0035098 [ESC/E(Z) complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0042127 [regulation of cell proliferation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0048863 [stem cell differentiation] GO:0051574 [positive regulation of histone H3-K9 methylation]