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A majority of cancer cells displayed weak to moderate cytoplasmic staining. Several cases of colorectal, pancreatic and breast cancers were strongly stained. Several malignant lymphomas and renal cancers were negative.
GENE INFORMATION
Gene name
ARHGAP31 (HGNC Symbol)
Synonyms
CDGAP
Description
Rho GTPase activating protein 31 (HGNC Symbol)
Entrez gene summary
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]