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Cytoplasmic and membranous expression mainly in glandular cells of gastrointestinal tract, breast, salivary gland, prostate, cells in renal tubules and urothelial cells.
Prostate cancers exhibited strong cytoplasmic immunoreactivity with luminal accentuation. Breast cancers showed moderate to strong cytoplasmic staining. The remaining tumors were either weakly stained or negative.
Breast and prostate cancers showed moderate to strong cytoplasmic positivity. The remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
RAB27B
Synonyms
Description
RAB27B, member RAS oncogene family (HGNC Symbol)
Entrez gene summary
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]