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Most malignancies displayed moderate to strong nuclear and occasionally cytoplasmic immunoreactivity. Several cases of prostate and endometrial cancers were weakly stained or negative.
GENE INFORMATION
Gene name
OGFR (HGNC Symbol)
Synonyms
7-60
Description
Opioid growth factor receptor (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]