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Moderate to strong granular cytoplasmic immunoreactivity in most tumor cells. Papillary adenocarcinomas of thyroid and several renal cancers were weakly stained or negative.
This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]