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Cases of colorectal, lung, gastric, gynaecological cancers and melanoma showed moderate to strong granular cytoplasmic positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
KCNAB2 (HGNC Symbol)
Synonyms
AKR6A5, HKvbeta2.1, HKvbeta2.2, KCNA2B
Description
Potassium channel, voltage gated subfamily A regulatory beta subunit 2 (HGNC Symbol)
Entrez gene summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]