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A majority of malignant cells showed weak to moderate nuclear positivity. A few tissues showed additional cytoplasmic staining. Malignant glioma, colorectal cancers and malignant melanomas were strongly stained. Renal cancers were negative.
GENE INFORMATION
Gene name
MBD3
Synonyms
Description
Methyl-CpG binding domain protein 3 (HGNC Symbol)
Entrez gene summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]