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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STK10
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STK10

Gene description

Serine/threonine kinase 10

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 2 antibodies.
HPA015083 , CAB020840
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

HPA015083
CAB020840

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Non-Hodgkins lymphomas displayed moderate to strong cytoplasmic positivity. Malignant melanomas exhibited moderate staining in several cases. Several testicular, pancreatic, breast and urothelial tumors showed weak immunoreactivity. Remaining cancers were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues exhibited weak to moderate nuclear and/or cytoplasmic immunoreactivity. Most prostate cancers and several cases of lymphomas, lung, ovarian and renal cancers were negative.

GENE INFORMATION

Gene name

STK10 (HGNC Symbol)

Synonyms

LOK, PRO2729

Description

Serine/threonine kinase 10 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

172042073 - 172188386

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072786 (version 83.38)

Entrez gene

6793

UniProt

O94804 (UniProt - Evidence at protein level)

neXtProt

NX_O94804

Antibodypedia

STK10 antibodies

PROTEIN BROWSER

STK10-001
STK10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK10-001
ENSP00000176763
ENST00000176763
O94804 [Direct mapping]
Serine/threonine-protein kinase 10
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042801 [polo kinase kinase activity]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0070062 [extracellular exosome]
GO:0071593 [lymphocyte aggregation]
GO:2000401 [regulation of lymphocyte migration]
Show all
968 aa
112.1 kDa
No 0
STK10-017
ENSP00000428806
ENST00000520476
H0YB71 [Direct mapping]
Serine/threonine-protein kinase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
281 aa
32.9 kDa
No 0

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