Non-Hodgkins lymphomas displayed moderate to strong cytoplasmic positivity. Malignant melanomas exhibited moderate staining in several cases. Several testicular, pancreatic, breast and urothelial tumors showed weak immunoreactivity. Remaining cancers were mainly negative.
Cancer tissues exhibited weak to moderate nuclear and/or cytoplasmic immunoreactivity. Most prostate cancers and several cases of lymphomas, lung, ovarian and renal cancers were negative.
STK10 (HGNC Symbol)
Serine/threonine kinase 10 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)