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Cancer tissues showed weak to moderate cytoplasmic and occasional nuclear positivity. A few cases of non-Hodgkins lymphomas were strongly stained. Many cases of colorectal, prostate, lung and renal cancers were negative.
Cancer tissues showed weak to moderate cytoplasmic immunoreactivity with additional nuclear positivity in a few cases. Cases of prostate cancers were strongly stained. Several lymphomas, lung, skin, endometrial and breast cancers were negative.
GENE INFORMATION
Gene name
MKRN2 (HGNC Symbol)
Synonyms
HSPC070, RNF62
Description
Makorin ring finger protein 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]