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Cancer tissues generally showed moderate cytoplasmic staining. A few cases of prostate cancers were strongly stained. Several cases of gliomas, renal and skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SYNJ2 (HGNC Symbol)
Synonyms
INPP5H
Description
Synaptojanin 2 (HGNC Symbol)
Entrez gene summary
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]