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This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0034260 [negative regulation of GTPase activity] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0034260 [negative regulation of GTPase activity] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0098779 [mitophagy in response to mitochondrial depolarization]