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Weak to moderate cytoplasmic positivity was observed in several cases of gliomas and melanomas along with breast, prostate, skin and testicular cancers. Remaining cancers were in general weakly stained or negative.
Several malignant cases were weak to moderate cytoplasmic stained. Other cases were negative. Staining pattern was often granular.
GENE INFORMATION
Gene name
SEPT3 (HGNC Symbol)
Synonyms
SEP3
Description
Septin 3 (HGNC Symbol)
Entrez gene summary
This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]