We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
TRPA1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TRPA1

Gene description

Transient receptor potential cation channel, subfamily A, member 1

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (urinary bladder)
GTEx:Group enriched (colon, small intestine, stomach, urinary bladder)
FANTOM5:Tissue enhanced (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in gastrointestinal tract, gall bladder and urinary bladder.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA026630
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine, stomach, urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION

Gene name

TRPA1 (HGNC Symbol)

Synonyms

ANKTM1

Description

Transient receptor potential cation channel, subfamily A, member 1 (HGNC Symbol)

Entrez gene summary

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.11

Chromosome location (bp)

72019917 - 72075617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104321 (version 83.38)

Entrez gene

8989

UniProt

O75762 (UniProt - Evidence at protein level)

neXtProt

NX_O75762

Antibodypedia

TRPA1 antibodies

PROTEIN BROWSER

TRPA1-001
TRPA1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPA1-001
ENSP00000262209
ENST00000262209
O75762 [Direct mapping]
Transient receptor potential cation channel subfamily A member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005218 [intracellular ligand-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009409 [response to cold]
GO:0010033 [response to organic substance]
GO:0014070 [response to organic cyclic compound]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0019233 [sensory perception of pain]
GO:0032421 [stereocilium bundle]
GO:0034220 [ion transmembrane transport]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0048265 [response to pain]
GO:0050955 [thermoception]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0050968 [detection of chemical stimulus involved in sensory perception of pain]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097604 [temperature-gated cation channel activity]
Show all
1119 aa
127.5 kDa
No 6
TRPA1-002
ENSP00000428151
ENST00000523582
H0YAW0 [Direct mapping]
Transient receptor potential cation channel subfamily A member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
916 aa
103.5 kDa
No 6

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.