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Most cancer tissues showed moderate cytoplasmic positivity with additional nuclear staining in several cases. Occasional squamous cell carcinomas of skin and hepatocellular carcinomas were strongly stained. Renal cancers, gliomas along with several cases of prostate and urothelial cancers were weakly stained or negative.
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]