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A majority of cancer cells showed weak to moderate cytoplasmic positivity with a granular pattern. Gliomas, breast, prostate, urothelial, renal and gastric cancers were generally negative.
A few cases of non-Hodgkins lymphomas as well as isolated cases of melanomas, renal and gastric cancers showed moderate to strong cytoplasmic immunoreactivity. Cancer cells in general were negative.
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]