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Most cholangiocarcinomas along with several colorectal, ovarian, cervical and urothelial cancers showed moderate cytoplasmic positivity. Remaining malignant cells were in general weakly stained or negative.
Several colorectal, ovarian, endometrial, head-neck, pancreatic and urinary bladder showed moderate to strong cytoplasmic and/or membranous staining. A majority of breast cancers displayed moderate cytoplasmic staining.
A majority of malignant cells displayed moderate cytoplasmic immunoreactivity. Thyroid cancers and a few cases of colorectal cancers revealed strong positivity. Most skin cancers, malignant lymphomas and gliomas were negative.
GENE INFORMATION
Gene name
KRT23 (HGNC Symbol)
Synonyms
CK23, DKFZP434G032, HAIK1, K23, MGC26158
Description
Keratin 23, type I (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]