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Few cases of liver, breast and urothelial cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues along with stromal cells were negative.
Cancer tissues displayed weak to moderate cytoplasmic staining. Occasional cases of melanomas, colorectal, endometrial, urothelial, renal, stomach, pancreatic and liver cancers along with most papillary adenocarcinomas of thyroid were strongly positive.
GENE INFORMATION
Gene name
TRIM3 (HGNC Symbol)
Synonyms
BERP, HAC1, RNF22, RNF97
Description
Tripartite motif containing 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]