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Cancer tissues showed moderate cytoplasmic positivity with additional membranous staining in several cases. Papillary adenocarcinomas of thyroid along with several cases of melanomas, carcinoids and renal cancers displayed strong positivity.
GENE INFORMATION
Gene name
GNPDA1 (HGNC Symbol)
Synonyms
GNPDA, GNPI, GPI, HLN, KIAA0060
Description
Glucosamine-6-phosphate deaminase 1 (HGNC Symbol)
Entrez gene summary
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]