We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
BBX
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

BBX

Gene descriptioni

Gene description according to HGNC.

Bobby sox homolog (Drosophila)

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Predicted intracellular proteins
Transcription factors

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

21
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Nuclear expression in many tissues.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 2 antibodies.
HPA006049 , HPA050646
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA006049
HPA050646

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Fractions of gliomas displayed moderate to strong nuclear and cytoplasmic staining. Remaining cancers showed nuclear positivity i a few cases whereas the majority of cases were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Most cancer tissues showed weak to moderate nuclear immunoreactivity. Few gliomas and squamous cell carcinomas along with most hepatocellular carcinomas and follicular adenocarcinomas of thyroid were strongly stained. Several testis cancers were negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

BBX (HGNC Symbol)

Synonyms

HBP2, HSPC339, MDS001

Description

Bobby sox homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q13.12

Chromosome location (bp)

107522936 - 107811324

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114439 (version 83.38)

Entrez gene

56987

UniProt

Q8WY36 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WY36

Antibodypedia

BBX antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
BBX-001
BBX-002
BBX-004
BBX-005
BBX-006
BBX-007
BBX-009
BBX-010
BBX-011
BBX-012
BBX-013
BBX-015
BBX-017
BBX-018
BBX-019
BBX-020
BBX-021
BBX-022
BBX-026
BBX-027
BBX-028
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BBX-001
ENSP00000408358
ENST00000415149
Q8WY36 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
911 aa
101.6 kDa
No 0
BBX-002
ENSP00000385317
ENST00000402543
C9JA69 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
891 aa
99.3 kDa
No 0
BBX-004
ENSP00000385518
ENST00000402163
C9J8D0 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
448 aa
50.7 kDa
No 0
BBX-005
ENSP00000385530
ENST00000406780
Q8WY36 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
911 aa
101.6 kDa
No 0
BBX-006
ENSP00000403860
ENST00000416476
Q8WY36 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
628 aa
71.5 kDa
No 0
BBX-007
ENSP00000319974
ENST00000325805
Q8WY36 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0060348 [bone development]
Show all
941 aa
105.1 kDa
No 0
BBX-009
ENSP00000413320
ENST00000427402
C9JYU6 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
193 aa
22.3 kDa
No 0
BBX-010
ENSP00000392230
ENST00000431630
C9IYG9 [Direct mapping]
HMG box transcription factor BBX
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
119 aa
13.6 kDa
No 0
BBX-011
ENSP00000408297
ENST00000449335
C9JNU3 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
144 aa
16.8 kDa
No 0
BBX-012
ENSP00000400543
ENST00000456817
C9IYS9 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
71 aa
8.1 kDa
No 0
BBX-013
ENSP00000404654
ENST00000458458
C9JE62 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
98 aa
11.3 kDa
No 0
BBX-015
ENSP00000413274
ENST00000456419
C9JZA0 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
205 aa
23.7 kDa
No 0
BBX-017
ENSP00000406554
ENST00000449271
C9J0J4 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
114 aa
13.2 kDa
No 0
BBX-018
ENSP00000403806
ENST00000413213
C9JIZ2 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
149 aa
17.4 kDa
No 0
BBX-019
ENSP00000412390
ENST00000425868
C9J067 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
24 aa
2.7 kDa
No 0
BBX-020
ENSP00000407662
ENST00000449213
C9K0D1 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
159 aa
18.5 kDa
No 0
BBX-021
ENSP00000404943
ENST00000457496
C9JC04 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
85 aa
9.7 kDa
No 0
BBX-022
ENSP00000414673
ENST00000429270
C9JSH4 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
166 aa
19.2 kDa
No 0
BBX-026
ENSP00000401524
ENST00000458347
H7C1Q0 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
131 aa
14.2 kDa
No 0
BBX-027
ENSP00000402372
ENST00000443253
H7C1U1 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
80 aa
9.1 kDa
No 0
BBX-028
ENSP00000396373
ENST00000454540
C9JD74 [Direct mapping]
HMG box transcription factor BBX
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
13 aa
1.5 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.