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Moderate cytoplasmic staining was observed in a majority of malignant cells. Most colorectal carcinomas and prostate cancers demonstrated strong cytoplasmic immunoreactivity. Renal cancers were either moderately positive or negative.
GENE INFORMATION
Gene name
SRM (HGNC Symbol)
Synonyms
SPS1, SRML1
Description
Spermidine synthase (HGNC Symbol)
Entrez gene summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]