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Cancer tissues displayed weak to moderate cytoplasmic positivity. Additional membranous positivity was observed in pancreatic, several cases of colorectal, breast and stomach cancers. A few cases of hepatocellular carcinomas showed strong immunoreactivity.
GENE INFORMATION
Gene name
DPH5 (HGNC Symbol)
Synonyms
CGI-30
Description
Diphthamide biosynthesis 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]