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Most cancer tissues showed moderate to strong granular cytoplasmic immunoreactivity. Most renal cancers as well as several malignant gliomas and skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TNFSF18 (HGNC Symbol)
Synonyms
AITRL, hGITRL, TL6
Description
Tumor necrosis factor (ligand) superfamily, member 18 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]