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Colorectal, breast, prostate, ovarian, cervical, endometrial and several hepatocellular carcinomas showed moderate to strong cytoplasmic and membranous positivity. Remaining cancer tissues were generally weakly stained or negative.
GENE INFORMATION
Gene name
NDUFAF4 (HGNC Symbol)
Synonyms
bA22L21.1, C6orf66, HRPAP20, HSPC125, My013
Description
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 (HGNC Symbol)
Entrez gene summary
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. [provided by RefSeq, Oct 2009]