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A majority of cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed in a few cases of colorectal cancer, lung cancer and lymphoma, while most renal- and liver cancers were negative.
A majority of cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Rare cases showed additional nuclear staining.
GENE INFORMATION
Gene name
UPF3B (HGNC Symbol)
Synonyms
HUPF3B, MRX62, RENT3B, UPF3X
Description
UPF3 regulator of nonsense transcripts homolog B (yeast) (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]