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Cancer tissues showed weak to moderate nuclear and cytoplasmic staining. A single case each of squamous cell carcinoma of skin and melanoma displayed strong staining.
A majority of cancer tissues showed moderate to strong cytoplasmic and nuclear immunoreactivity. Endometrial, pancreatic, gastric, renal, cervical and prostate cancer were mainly weakly stained or negative.
GENE INFORMATION
Gene name
UBE2M (HGNC Symbol)
Synonyms
hUbc12, UBC12
Description
Ubiquitin-conjugating enzyme E2M (HGNC Symbol)
Entrez gene summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]