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Malignant gliomas and carcinoids as well as several testicular embryonal cancers displayed moderate staining. Malignant cells in general were negative.
GENE INFORMATION
Gene name
MAP1B (HGNC Symbol)
Synonyms
MAP5, PPP1R102
Description
Microtubule-associated protein 1B (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]