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Moderate to strong nuclear staining was observed in most malignancies. Several endometrial, thyroid, renal, lung, gastric and cervical cancers were weakly stained or negative.
GENE INFORMATION
Gene name
LIN28A (HGNC Symbol)
Synonyms
CSDD1, FLJ12457, LIN-28, LIN28, ZCCHC1
Description
Lin-28 homolog A (C. elegans) (HGNC Symbol)
Entrez gene summary
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]