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Most cancers displayed several cases with moderate to strong nuclear immunoreactivity. Many cases of gliomas, melanomas, breast, prostate, renal and liver cancers were weakly stained or negative.
Cancer cells showed moderate to strong nuclear positivity. Several kidney, stomach, liver, breast, prostate cancers along with a few carcinoids and gliomas were weakly stained or negative.
Moderate to strong nuclear immunoreactivity was observed in most cancer tissues. Several cases of carcinoids along with a few lymphomas and prostate cancers were negative.
Nuclear autoantigenic sperm protein (histone-binding) (HGNC Symbol)
Entrez gene summary
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
P49321 [Direct mapping] Nuclear autoantigenic sperm protein
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Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P49321 [Direct mapping] Nuclear autoantigenic sperm protein Q5T626 [Target identity:100%; Query identity:100%] Nuclear autoantigenic sperm protein (Histone-binding); Nuclear autoantigenic sperm protein (Histone-binding), isoform CRA_a
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Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P49321 [Direct mapping] Nuclear autoantigenic sperm protein
Show all
Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)