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Most cancers showed weak to mdoerate nuclear immunoreactivity. Additional cytoplasmic positivity was observed in a few cases. Several cases of ovarian, testicular and renal cancers weer strongly stained. Most cases of breast, lung and prostate cancers were negative.
GENE INFORMATION
Gene name
FBXO44 (HGNC Symbol)
Synonyms
FBG3, FBX30, Fbx44, Fbxo6a, MGC14140
Description
F-box protein 44 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]