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The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0021670 [lateral ventricle development] GO:0021849 [neuroblast division in subventricular zone] GO:0030136 [clathrin-coated vesicle] GO:0030335 [positive regulation of cell migration] GO:0050769 [positive regulation of neurogenesis] GO:1903077 [negative regulation of protein localization to plasma membrane]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0021670 [lateral ventricle development] GO:0021849 [neuroblast division in subventricular zone] GO:0030136 [clathrin-coated vesicle] GO:0030335 [positive regulation of cell migration] GO:0050769 [positive regulation of neurogenesis] GO:1903077 [negative regulation of protein localization to plasma membrane]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007219 [Notch signaling pathway] GO:0007411 [axon guidance] GO:0021670 [lateral ventricle development] GO:0021849 [neuroblast division in subventricular zone] GO:0030136 [clathrin-coated vesicle] GO:0030335 [positive regulation of cell migration] GO:0050769 [positive regulation of neurogenesis] GO:1903077 [negative regulation of protein localization to plasma membrane]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0007405 [neuroblast proliferation] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0008013 [beta-catenin binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0019897 [extrinsic component of plasma membrane] GO:0021670 [lateral ventricle development] GO:0021849 [neuroblast division in subventricular zone] GO:0030136 [clathrin-coated vesicle] GO:0030335 [positive regulation of cell migration] GO:0030862 [positive regulation of polarized epithelial cell differentiation] GO:0030900 [forebrain development] GO:0034332 [adherens junction organization] GO:0045177 [apical part of cell] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0045746 [negative regulation of Notch signaling pathway] GO:0050769 [positive regulation of neurogenesis] GO:0060487 [lung epithelial cell differentiation] GO:1903077 [negative regulation of protein localization to plasma membrane]