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Moderate to strong cytoplasmic immunoreactivity with a granular pattern was observed in most malignant cells. Additional membranous staining was displayed in colorectal cancers. Most cases of renal cancers and several cases of hepatocellular carcinomas and malignant lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
TMEM165 (HGNC Symbol)
Synonyms
GDT1, TMPT27, TPARL
Description
Transmembrane protein 165 (HGNC Symbol)
Entrez gene summary
This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]