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The malignant cells displayed weak to moderate cytoplasmic staining. Malignant gliomas, hepatocellular cancers in liver and prostate cancers were negative.
Malignant cells were weakly stained in the cytoplasm or generally negative. Moderate cytoplasmic and rare nuclear positivity was observed in a few cases of malignant lymphomas, thyroid, testicular and urothelial cancers.
GENE INFORMATION
Gene name
TES (HGNC Symbol)
Synonyms
DKFZP586B2022, TESS-2, TESTIN
Description
Testin LIM domain protein (HGNC Symbol)
Entrez gene summary
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]