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Single case of lung adenocarcinoma displayed strong cytoplasmic positivity. Rare cases of testicular, renal and prostate cancers were moderately positive. Remaining cancer tissues were generally negative.
Most tumour cells showed moderate cytoplasmic staining. Hodgkin's lymphoma showed distinct cytoplasmic positivity. Most melanomas, prostate, renal and liver cancers as well as a majority of squamous cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
FBXL8 (HGNC Symbol)
Synonyms
Fbl8
Description
F-box and leucine-rich repeat protein 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]