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NUDT15

GENERAL INFORMATION

Gene name

 NUDT15

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 15

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038969
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038969

GENE INFORMATION

Gene name

 NUDT15 (HGNC Symbol)

Synonyms

 FLJ10956, MTH2

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 15 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 48037567 - 48047222

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136159 (version 83.38)

Entrez gene

 55270

UniProt

 Q9NV35 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NV35

Antibodypedia

 NUDT15 antibodies

PROTEIN BROWSER
NUDT15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT15-001
ENSP00000258662
ENST00000258662
Q9NV35 [Direct mapping]
Probable 8-oxo-dGTP diphosphatase NUDT15
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005829 [cytosol]
GO:0006203 [dGTP catabolic process]
GO:0008413 [8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity]
GO:0016787 [hydrolase activity]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0035539 [8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 164 aa
18.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.