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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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NUDT15
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NUDT15

Gene description

Nudix (nucleoside diphosphate linked moiety X)-type motif 15

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA038969
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PROGNOSTIC SUMMARY

Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA038969

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern.

GENE INFORMATION

Gene name

NUDT15 (HGNC Symbol)

Synonyms

FLJ10956, MTH2

Description

Nudix (nucleoside diphosphate linked moiety X)-type motif 15 (HGNC Symbol)

Entrez gene summary

Chromosome

13

Cytoband

q14.2

Chromosome location (bp)

48037567 - 48047222

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136159 (version 83.38)

Entrez gene

55270

UniProt

Q9NV35 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NV35

Antibodypedia

NUDT15 antibodies

PROTEIN BROWSER

NUDT15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NUDT15-001
ENSP00000258662
ENST00000258662
Q9NV35 [Direct mapping]
Probable 8-oxo-dGTP diphosphatase NUDT15
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006203 [dGTP catabolic process]
GO:0008413 [8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity]
GO:0016787 [hydrolase activity]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0035539 [8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
164 aa
18.6 kDa
No 0

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