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Most cancer cells displayed moderate to strong cytoplasmic staining. Several cases of gliomas, cervical, skin, urothelial and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
IER3 (HGNC Symbol)
Synonyms
DIF-2, IEX-1, IEX-1L, PRG1
Description
Immediate early response 3 (HGNC Symbol)
Entrez gene summary
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
GO:0001562 [response to protozoan] GO:0003085 [negative regulation of systemic arterial blood pressure] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006282 [regulation of DNA repair] GO:0006915 [apoptotic process] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045820 [negative regulation of glycolytic process] GO:0046822 [regulation of nucleocytoplasmic transport] GO:0050728 [negative regulation of inflammatory response] GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:2000377 [regulation of reactive oxygen species metabolic process] GO:2001020 [regulation of response to DNA damage stimulus]