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Most malignancies were weakly stained. Malignant melanomas, liver, thyroid and colorectal cancer as well as several malignant gliomas, testicular and lung cancers displayed moderate to strong cytoplasmic positivity.
Weak to moderate cytoplasmic staining in most malignancies. Malignant melanomas were strongly stained and a few cases of colo-rectal and endometrial cancers were also strongly stained. Gliomas were generally negative.
GENE INFORMATION
Gene name
SDCBP (HGNC Symbol)
Synonyms
SYCL
Description
Syndecan binding protein (syntenin) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)