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In atlas

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Reliability

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Validation

Method

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Searches

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Expression

Tissue

Specificity

Cell line

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Cancer

Specificity

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Detectable

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Detectable

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AKT1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

AKT1

Gene descriptioni

Gene description according to HGNC.

V-akt murine thymoma viral oncogene homolog 1

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

Read more

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expressioni

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 2 antibodies.
HPA002891 , CAB003765
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARYi

Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.

RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.

Read more
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEWi

Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.

HPA dataseti

HPA dataset
RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.

RNA tissue category HPA
HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti

GTEx dataset
RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.

RNA tissue category GTEx
GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti

FANTOM5 dataset
Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.

RNA tissue category FANTOM5
FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

AKT1 (HGNC Symbol)

Synonyms

AKT, PKB, PRKBA, RAC

Description

V-akt murine thymoma viral oncogene homolog 1 (HGNC Symbol)

Entrez gene summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

14

Cytoband

q32.33

Chromosome location (bp)

104769349 - 104795751

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142208 (version 83.38)

Entrez gene

207

UniProt

P31749 (UniProt - Evidence at protein level)

neXtProt

NX_P31749

Antibodypedia

AKT1 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

AKT1-001
AKT1-002
AKT1-003
AKT1-004
AKT1-005
AKT1-006
AKT1-010
AKT1-014
AKT1-018

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKT1-001
ENSP00000270202
ENST00000349310
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009408 [response to heat]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-002
ENSP00000384293
ENST00000407796
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009408 [response to heat]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-003
ENSP00000385326
ENST00000402615
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009408 [response to heat]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-004
ENSP00000451166
ENST00000554848
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009408 [response to heat]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-005
ENSP00000451828
ENST00000554581
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001649 [osteoblast differentiation]
GO:0001893 [maternal placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005977 [glycogen metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006412 [translation]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0015758 [glucose transport]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016567 [protein ubiquitination]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021510 [spinal cord development]
GO:0030030 [cell projection organization]
GO:0030154 [cell differentiation]
GO:0030163 [protein catabolic process]
GO:0030168 [platelet activation]
GO:0030212 [hyaluronan metabolic process]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031641 [regulation of myelination]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032094 [response to food]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032287 [peripheral nervous system myelin maintenance]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032794 [GTPase activating protein binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0032880 [regulation of protein localization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036064 [ciliary basal body]
GO:0036294 [cellular response to decreased oxygen levels]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043491 [protein kinase B signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045792 [negative regulation of cell size]
GO:0045861 [negative regulation of proteolysis]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046329 [negative regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051146 [striated muscle cell differentiation]
GO:0051721 [protein phosphatase 2A binding]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0060709 [glycogen cell differentiation involved in embryonic placenta development]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901653 [cellular response to peptide]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-006
ENSP00000450688
ENST00000555528
P31749 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
B0LPE5 [Target identity:100%; Query identity:100%]
V-akt murine thymoma viral oncogene homolog 1; V-akt murine thymoma viral oncogene homolog 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006915 [apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009408 [response to heat]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010975 [regulation of neuron projection development]
GO:0012501 [programmed cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031018 [endocrine pancreas development]
GO:0031295 [T cell costimulation]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031982 [vesicle]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034405 [response to fluid shear stress]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0043488 [regulation of mRNA stability]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0046209 [nitric oxide metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060416 [response to growth hormone]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0071889 [14-3-3 protein binding]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0072656 [maintenance of protein location in mitochondrion]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901976 [regulation of cell cycle checkpoint]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903599 [positive regulation of mitophagy]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
480 aa
55.7 kDa
No 0
AKT1-010
ENSP00000450681
ENST00000554192
G3V2I6 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
184 aa
20.9 kDa
No 0
AKT1-014
ENSP00000451824
ENST00000555926
G3V4I6 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
92 aa
11 kDa
No 0
AKT1-018
ENSP00000451470
ENST00000555458
G3V3X1 [Direct mapping]
RAC-alpha serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
170 aa
19.3 kDa
No 0

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The Human Protein Atlas project is funded
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