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Most of the malignancies showed weak to moderate cytoplasmic immunoreactivity. Several hepatocellular carcinomas and endometrial cancers along with a few testicular seminomas were strongly stained. Most malignant gliomas and lymphomas along with several squamous cell carcinomas were negative.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]