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Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, U-698, U-87 MG, WM-115)
HPA (normal tissue):
Tissue enhanced (liver, spleen)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in most tissues, including extracellular positivity.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most liver cancers along with several cases of pancreatic, renal, thyroid, ovarian and colorectal cancers showed moderate cytoplasmic and membranous staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CRHBP (HGNC Symbol)
Synonyms
CRF-BP, CRFBP
Description
Corticotropin releasing hormone binding protein (HGNC Symbol)
Entrez gene summary
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]