We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
EGFR
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

EGFR

Gene descriptioni

Gene description according to HGNC.

Epidermal growth factor receptor

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Membrane,Secreted

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (A-431)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic and membranous expression in several tissues, most abundant in placenta.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 5 antibodies.
HPA001200 , HPA018530 , CAB000035 , CAB068186 , CAB073534
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA001200
HPA018530
CAB000035
CAB068186
CAB073534

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Selected cases of glioma showed strong membranous and cytoplasmic positivity. Remaining cancer tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Most malignancies showed weak to moderate cytoplasmic immunoreactivity. Malignant gliomas displayed moderate to strong positivity. A majority of cases in malignant lymphomas, breast, prostate and ovarian cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Most cancer cells displayed a moderate to strong cytoplasmic positivity. Carcinoids, malignant lymphomas, melanomas and testis cancer were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Few cases of colorectal and lung cancers showed weak to moderate cytoplasmic and/or membranous positivity. Other cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

A majority of urothelial, cervical, skin, head and neck, and lung cancers showed moderate membranous and cytoplasmic positivity. Most remaining cancer cells were weakly stained or negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

EGFR (HGNC Symbol)

Synonyms

ERBB, ERBB1

Description

Epidermal growth factor receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

7

Cytoband

p11.2

Chromosome location (bp)

55019021 - 55256620

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146648 (version 83.38)

Entrez gene

1956

UniProt

P00533 (UniProt - Evidence at protein level)

neXtProt

NX_P00533

Antibodypedia

EGFR antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

EGFR-001
EGFR-002
EGFR-003
EGFR-004
EGFR-005
EGFR-009
EGFR-201
EGFR-202

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EGFR-001
ENSP00000275493
ENST00000275493
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001892 [embryonic placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007435 [salivary gland morphogenesis]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0021795 [cerebral cortex cell migration]
GO:0030122 [AP-2 adaptor complex]
GO:0030139 [endocytic vesicle]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
1210 aa
134.3 kDa
Yes 1
EGFR-002
ENSP00000345973
ENST00000344576
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
705 aa
77.3 kDa
Yes 0
EGFR-003
ENSP00000342376
ENST00000342916
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
628 aa
69.2 kDa
Yes 0
EGFR-004
ENSP00000415559
ENST00000455089
Q504U8 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
1091 aa
120.7 kDa
Yes 1
EGFR-005
ENSP00000413843
ENST00000420316
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
405 aa
44.7 kDa
Yes 0
EGFR-009
ENSP00000413354
ENST00000450046
C9JYS6 [Direct mapping]
Epidermal growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
128 aa
14.7 kDa
No 0
EGFR-201
ENSP00000410031
ENST00000442591
A0A0B4J1Y5 [Direct mapping]
Epidermal growth factor receptor; Epidermal growth factor receptor (Erythroblastic leukemia viral (V-erb-b) oncogene homolog, avian), isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
657 aa
72.4 kDa
Yes 0
EGFR-202
ENSP00000395243
ENST00000454757
E9PFD7 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
1165 aa
129.2 kDa
Yes 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.