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A majority of cancer tissues were negative. Lung cancers showed a few strongly stained cases, cytoplasmic, while renal cancers showed moderate to strong staining. Hepatocellular and endometrial cancers showed a few moderately immunoreactive cases.
Colorectal, ovarian and endometrial cancers along with a few cases of breast, prostate, renal, gastric and pancreatic cancers displayed moderate to strong granular cytoplasmic immunoreactivity. Remaining malignant cells were mainly negative.
GENE INFORMATION
Gene name
PSPH (HGNC Symbol)
Synonyms
PSP
Description
Phosphoserine phosphatase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)