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Melanomas and basal cell carcinomas along with few gliomas, ovarian, cervical and endometrial cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were mostly negative.
Most cancers showed few cases of moderate cytoplasmic positivity. Gliomas and skin cancer displayed many positive cases.
GENE INFORMATION
Gene name
DOCK1 (HGNC Symbol)
Synonyms
ced5, DOCK180
Description
Dedicator of cytokinesis 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Q14185 [Direct mapping] Dedicator of cytokinesis protein 1
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)